Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 416 for “"MicroRNA"”.
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… has demonstrated that aberrant expression of microRNAs (miRs), a class of small non-coding regulatory RNAs, can be an important factor in prostate cancer metastasis. Previous studies in our laboratory identified serum miR-194 and miR-375 as novel markers of disease progression in men with PCa. …
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I MICRORNA NELLE DISTROFIE MIOTONICHE
… consequence of an RNA gain of toxic function. MicroRNAs (miRNAs) are short non-coding RNAs (~22 nucleotides) regulating gene expression post-trascriptionally either via the degradation of target mRNAs or the inhibition of protein translation. MicroRNAs have been shown to be involved in a range …
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Luminescence-Based MicroRNA Detection Methods
MicroRNAs (miRNA) are short, 18-24 nucleotide long noncoding RNAs. These small RNAs, which are initially transcribed in the nucleus, are transported into the cell cytoplasm where they regulate protein translation either through direct cleavage of mRNA, or indirect inhibition through binding to mRNA …
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MicroRNA cloning and bioinformatic analysis
… and precursor structures of let-7 and lin-4 as microRNAs (miRNAs). The size of this class of genes, and its prevalence in other genomes, are unknown. Therefore, we developed an experimental and bioinformatics strategy to identify novel miRNA genes. We discovered a total of 75 miRNA genes in the …
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MicroRNA Function in Cellular Stress Response
<p>MicroRNAs are key post-transcriptional regulators that have been found to play critical roles in the regulation of cellular functions. There is an emerging concept that microRNAs may be just as essential for fine-tuning physiological functions and responding to changing environments and stress …
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SR proteins in microRNA/mRNA biogenesis
… study their functional involvement in regulating microRNA/mRNA biogenesis and their own expression. </p><p>Negative feedback regulation is a common mechanism maintaining the steady-state level of SR proteins (i.e. SC35 and SRp20), and several mechanism may be involved. In order to test if miRNAs …
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Extracellular Vesicle Capture and microRNA Detection
… have been found to carry proteins, DNA, mRNA and microRNA as well surface markers indicative of the their cell origin. Thus developing methods to profile extracellular vesicles and interrogate the contents of these vesicles is a growing area of research and has the potential to develop into a …
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Homeobox gene and microRNA duplication in Chelicerata
… to these possible WGD events, homeobox genes and microRNAs (miRNAs) were systematically identified and characterised in chelicerates with evidence for WGDs as well as lineages with no data supporting WGD. The identified pervasive duplication of homeobox genes and miRNAs in arachnopulmonates, which …
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Clinical and Biological Aspects of Cardiovascular microRNA
… smooth muscle cells towards the vessel lumen. microRNA (miRNA) is a class of short non-coding RNA which regulate gene expression through part-complimentary binding to target sites preferably within the 3’-UTR of specific mRNAs. miRNAs have pervasive roles in animal biology and aberrant …
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MICRORNA EXPRESSION WITHIN PERIOVULATORY MURAL GRANULOSA CELLS
… in maintaining the integrity of gene expression. MicroRNA (miRNA) are highly conserved, 21nt long RNA molecules that offer a way to regulate gene expression at the post-transcriptional level by binding to the 3'UTR region of a target mRNA and either preventing its translation or causing its …
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The E2F1-responsive microRNA-449 promotes apoptosis
… durch DNA-Schädigung. Um E2F1-responsive microRNAs zu identifizieren habe ich eine Microarray-Hybridisierung durchgeführt, und fand miR-449a und miR-449b (zusammen miR-449 genannt) stark durch E2F1 induziert. MiR-449 und sein Host-Gen CDC20B sind nach E2F1-Überexpression und nach …
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The functional microRNA landscape of mammalian development
MicroRNAs (miRNAs) constitute a class of ~22 nucleotide RNAs with broad regulatory roles in gene expression. Dependent largely on the enzyme Dicer for their generation from longer precursor transcripts, mammalian miRNAs direct posttranscriptional repression of mRNAs based on complementarity to …
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Understanding microRNA targeting with high-throughput biochemistry
MicroRNAs (miRNAs) are short RNAs that, in complex with Argonaute (AGO) proteins, guide repression of mRNA targets. miRNAs negatively regulate most mammalian mRNAs, and disruption of this regulation often results in severe defects at the cellular and organismal level. miRNA repression occurs …
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NEW FINDINGS INTO TARGET-DIRECTED MICRORNA DEGRADATION MECHANISM
MiRNAs are a class of small non-coding RNAs that function in post-transcriptional gene silencing by interacting with target RNAs. A novel mechanism in control of miRNA levels, called Target-Directed miRNA degradation (TDMD), has been described, which involves specific transcripts able to interact …
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Development of Computational to ols to Target Microrna
<p>MicroRNAs (a.k.a, miRNAs) play an important role in disease development. However, few of their structures have been determined and structure-based computational methods remain challenging in accurately predicting their interactions with small molecules. To address this issue, my thesis is to …
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Visualization and manipulation of microRNA in neural cells
microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the …
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Hormonal regulation of microRNA expression in the ovary
… regulation is the expression and function of microRNA (miRNA). These highly conserved, short, non-coding RNA molecules primarily silence gene expression by directly interfering with protein translation or causing the degradation of messenger RNA. The focus of these studies was to first …
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Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
… by cells that play a role in cell communication. MicroRNA (miRNA), small non-coding RNA carried by exosomes, are likely responsible for many exosome effects. Exosomes and miRNA therapies show promise in treating diseases such as cancer and arthritis, but there is no exosome or miRNA product yet …
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MicroRNA Dysregulation in Neuropsychiatric Disorders and Cognitive Dysfunction
MicroRNAs (miRNAs) are evolutionarily-conserved small non-coding RNAs that are important posttranscriptional regulators of gene expression. Genetic Variants may cause microRNA dysregulation and the concomitant aberrant target expression. The dysregulation of one or a few targets may in turn lead to …
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