Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 528 for “"MiRNA"”.
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Regulation of miRNA degradation
miRNAs are small RNAs that repress gene expression by guiding the effector protein Argonaute (Ago) to complementary sites in the 3′ UTRs of target genes. The levels of a miRNA in a given cell-type are determined by the balance of its rates of production and decay. Although much is known about miRNA …
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Building Profiles for miRNA Target Prediction
… current methods for determining the targets for miRNAs are far from accurate. To address this issue, we developed algorithms that produced profiles of miRNA recognition elements and features such binding energy threshold and conservation score. These profiles will be used to train a machine …
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MiRNA-Mediated Regulation of Colorectal Tumorigenesis
… lead to the development of cancer. MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as essential mediators of post-transcriptional gene regulation and are being increasingly recognized for their role in cancer. MiRNA expression is dysregulated in colon cancer and these changes in …
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Sequence determinants of pri-miRNA processing
MicroRNAs (miRNAs) are short RNAs that regulate many processes in physiology and pathology by guiding the repression of target messenger RNAs. For classification purposes, miRNAs are defined as ~22 nt RNAs that are produced by the cleavage of endogenously transcribed hairpins. From a cellular …
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miRNA expressione profiles in retinal neurodegenerative diseases
I micro RNA (miRNAs) sono piccole molecole di RNA non codificative che regolano l'espressione genica a livello post-trascrizionale e post-trasduzionale. Diversi studi dimostrano che i microRNA regolano diversi processi cellulari tra cui differenziazione, crescita, invecchiamento, apoptosi, …
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Biochemically informed modeling of miRNA targeting efficacy
In metazoans, microRNAs (miRNAs) are short pieces of RNA that load into Argonaute (AGO) proteins and base-pair to complementary sequences in mRNAs. Upon binding an mRNA, AGO- miRNA complexes recruit machinery that translationally represses and degrades the mRNAs. Mammalian genomes encode hundreds …
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Genome-Wide Decoding of mRNP and miRNA Maps
… RNA-binding proteins (RNABPs) and/or microRNAs (miRNAs). However, applying biochemical methods to understand such interactions in living tissues is major challenge. Here we developed a genome-wide means of mapping messenger ribonucleoprotein (mRNP) sites in vivo, by high-throughput sequencing of …
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Profili di espressione dei miRNA nelle patologie vitreoretiniche.
I microRNA (miRNA) sono piccoli RNA non codificanti, in grado di regolare l'espressione genica a livello post-trascrizione e traslazionale. Diversi studi hanno dimostrato che i miRNA regolano vari processi cellulari, tra cui la differenziazione, lo sviluppo, l’invecchiamento, l’apoptosi, …
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Discovery of miRNA-regulated processes in mammalian development
… of non-coding ~22nt RNAs termed "microRNAs" (miRNAs). These RNAs guide the sequence-specific inhibition of translation and destabilization of mRNA targets through short (6-7 nucleotide) stretches of complementarity between the 5' end of the miRNA (seed region) and the 3' untranslated region …
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Implementation of global miRNA biomarker discovery in human plasma
… biomarkers. Small non-coding RNAs, specifically miRNAs, have been shown to exist extracellularly and are stable in biofluids, including blood and urine. The expression profile of extracellular miRNAs is also altered in a number of diseases making them attractive candidates for novel, non-invasive …
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Validierung von miRNA-Zielgen-Interaktionen und ihre Charakterisierung bei Motoneuronerkrankungen
MicroRNAs (miRNAs) sind eine kürzlich entdeckte Klasse posttranskriptioneller Genregulatoren, die in einer Vielzahl von Metazoen, Pflanzen und Viren verbreitet sind. Diese ~22nt langen, nicht kodierenden RNAs spielen ein entscheidende Rolle bei der Regulation vieler biologischer Prozesse, wie z.B. …
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Characterization of A Novel Oncogenic Mirna Inhibitor In Cancer Therapy
<p>As cancer research continues to move towards more personalized methods, targeted inhibitors of oncogenic drivers of cancer are found to be an innovative and promising therapeutic approach. Previously thought to be undruggable regions of the genome, RNA has become an area of increasing interest …
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A Neuroprotective Role for Mir-1017, a Non-Canonical Mirna
<p>miRNAs are post-transcriptional regulators of gene expression, with numerous being involved in neurobiology. Within the human genome a quarter of the identified miRNA loci derive from a class of miRNAs termed tailed mirtrons. Despite the identification of this large population of miRNA, no …
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A Network Approach to Understanding miRNA Regulation in Adipose Tissue
… we employ two contrasting approaches to identify miRNAs that influence adipocyte phenotype. First, miRNAs were sequenced from 6 fat pads, primary preadipocytes, and primary mature adipocytes. Comparative analyses of abundance across adipose tissue type and stage of differentiation revealed a …
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Prediction, validation and functional analysis of miRNA targets in Arabidopsis thaliana
MicroRNAs (miRNAs) are small noncoding RNAs whose function as modulators of gene expression is crucial for many aspects of plant and animal development. A major challenge in understanding the regulatory role of miRNAs is to accurately predict regulated targets. In this work, 281 novel miRNA targets …
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MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development
… study was to investigate if specific microRNAs (miRNAs) are responsible for neural induction, differentiation and fate specification and if they can induce MSCs to commit to a neuroblast and/or mature neuron cell lineage. The selected miRNAs were miR-107, miR-124 and miR-381, which respectively …
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Hypoxia Mediated Downregulation of Mirna Biogenesis Leads to Increased Tumor Progression
… tumor microenvironment leads to attenuation of miRNA biogenesis by downregulation of two key enzymes, Drosha and Dicer in cancer cells. Previous data from our laboratory had shown the clinical relevance of downregulated Dicer and Drosha in ovarian and other cancer types, but a clear mechanistic …
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Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA
… of MCC cases has been established. microRNAs (miRNA, miR) are a family of small non-coding RNAs which play a key role in post-transcriptional regulation of gene expression and are considered significant players in disease and development in many species. Whilst the focus of MCV research has …
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Functional study of miRNA-mRNA interactions in malaria mosquito An. gambiae
… body of evidence indicates that microRNAs (miRNAs) are involved in egg maturation and immune reactions against invading pathogens in mosquitoes. However, the molecular mechanisms by which specific miRNAs selectively modulate reproduction and the survival of pathogens are largely unknown. The …
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