Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Method Validation"”.
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Comparison of Supported Liquid Extraction and Solid Phase Extraction of Methamphetamine from Urine and Method Validation by Gas Chromatography-Mass Spectrometry
… MA from urine, SPE was found to be the preferred method.</p>
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Biomarker analysis for APRT deficiency diagnosis using UPLC-MS/MS
… stones in APRT deficiency patients. UPLC-MS/MS method for simultaneous quantification of DHA, adenine and the drugs, allopurinol, oxypurinol and febuxostat in human plasma had been developed. The objective of this study was to perform full validation of the UPLC-MS/MS quantification method …
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Analytical Methods Development for High-Throughput Photochemisty With Led Arrays
This thesis describes the design, construction, and evaluation of a series of LED array photolysis systems for high throughput photochemistry. Three generations of array systems of increasing sophistication are evaluated using calorimetric measurements and potassium tris(oxalato)ferrate(III) …
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Analysis of B [sigma] flavor oscillations at CDF
… are further used for algorithm calibration and method validation. The B mesons lifetimes are extracted. The measurement of the Bo oscillation frequency yields Amd = 0.522 ± 0.017 ps-1. The search for B, oscillations is performed using an amplitude method based on a frequency scanning procedure. …
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The development of physico-chemical quality control methods for Haemophilus influenzae type b vaccine production
… The Biovac Institute (TBI) required analytical method development in parallel with the production process development. Technology transfer enabled TBI to develop Hib vaccine production which could lead to the development of vaccine manufacturing capacity in subSaharan Africa. Initial studies …
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Development of a liquid-liquid, solid-phase extraction (SPE), LC-MS/MS analytical method for qualitative and quantitative drug residue analysis in white-tailed deer
… are based on qualitative and quantitative methods. These methods are used to determine the amount of compound present in a sample. The choice of analytical method of residue testing is based on the assessment of the benefits and disadvantages of the technique. Qualitative methods include, …
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Spatial and Temporal Performance Characteristics in a Two-Dimensional Human Motion Analysis System Using Digital Video Capture
… The first testing protocol involved developing a method to evaluate system spatial performance characteristics with respect to accuracy, precision, and resolution. A physical model comprising a calibration frame was constructed with phantom postures selected to represent joint angles and off-plane …
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Quantification of Total Phenolic Content and Antioxidant Activity of Oat Cultivars Grown in South Dakota
… total phenolic content was measured using AOAC method (method # 952.03, 1990). Extraction protocols were optimized for oat samples. Antioxidant activity, the free radical scavenging effect of oat extracts, was measured using the 1, 1 diphenyl 2 picrylhydrazyl (DPPH) assay. Pure standards (tannic …
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Simulation of urea particle flow using DEM for dry fertilizer spreading optimization
… This study aims to develop a discrete element method (DEM) model for urea and assessed it through a calibration and multi-method validation framework pertinent to fertilizer spreader applications. Urea was first characterized experimentally for particle size and density, and the DEM particles …
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Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for screening of selective androgen receptor modulators in urine and blood
… to address the lack of multi-residue analytical methods enabling the effective detection of emerging SARM compounds in a range of biofluids collected from different animal species. <br/><br/>Considering that urine and blood are generally the biological matrices of choice regulated by both …
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Effects of the Non-Newtonian Rheology on the Fluid-Structure Interactions in Biological Flows
… by the immersed boundary-lattice Boltzmann method (IB-LBM). Firstly, an efficient and accurate IB-LBM solver for FSIs involving non-Newtonian fluids is developed. The governing equations for non-Newtonian fluids are solved by the lattice Boltzmann method. Several solid structures including …
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Development of a GC-MS method and analysis of phenolic acids in fruit and spice matrices and evaluation of their antioxidant capacity
… phenolic acids using different assays. A GC/MS method was developed for the quantification of ten commonly present phenolic acids in plant foods. Target analytes were the benzoic acid based phenolic acids - anisic, gallic, p-hydroxy benzoic, o-salicylic, protocatechuic, and vanillic acids, …
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DEVELOPMENT OF STANDARD OPERATING PROCEDURE WITH MODIFIED METHOD TO QUANTIFY BENZENE AND OTHER VOLATILE ORGANIC COMPOUNDS IN AIR SAMPLES USING GAS CHROMATOGRAPHY
… operating procedure (SOP) and modify the current method for the detection of VOCs associated with oil and gas drilling activity to accommodate the equipment and capabilities of SFASU Environmental Assessment Lab. This study aims to provide the framework for future research in air quality …
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The development of methods for the determination of selenium using spectrofluorimetric and ICP-MS techniques.
Methods for both the on-line and off-line fluorimetric determination of total selenium and selenium species using 2-(alpha-pyridyl)-thioquinaldinamide (PTQA) as a fluorimetric reagent have been developed. As PTQA is not available on the market, methods for its synthesis were critically reviewed, …
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Analytical validation and evaluation of the effects of intramuscular injections on acute phase proteins in horses
Acute phase protein (APP) measurement can be used to characterize and detect inflammation, as well as monitor response to therapy. Intramuscular (IM) injections often result in local swelling and inflammation, which may lead to increased plasma concentrations of APP. The first objective of this …
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Method Development For Concentration Measurements of SVOCs and Analysis of Ambient Samples
… yield and environmental fate. Recently, a new methodology that allows sampling and analysis of the total (gas phase and PM) concentration of SVOCs in the atmosphere has been developed and tested on a class of SVOCs, namely, nitrophenols (Busca, 2010; Moukhtar et al., 2011; Saccon et al., 2013). …
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Measurement and risk assessment of endocrine disruptors present in sport supplements
… suitable for a range of sport supplements, the validation of both bioassays,a survey of 116 sport supplement samples and the demonstration of their suitability as a routine laboratory testing tool.<br/><br/>Validation according to Commission Decision 2002/657/EC (validation of …
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Outlining different perspectives for accurate MS-based proteomics in processed matrices - a case study on European feed control
… in feed. However, current official control methods only partially ensure compliance. Mass spectrometry (MS) offers a promising approach to ensure food and feed safety, though thermal processing may compromise its sensitivity. Hence, this thesis explores strategies to enhance MS-based …
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Innleiðing einnar mæliaðferðar á LC-MS/MS fyrir átján sterahormón
… of a CE or IVDR marked measurement method instead of laboratory developed LC-MS methods. The first aim of this project was to implement on LC-MS/MS an EU IVDR certified steroid panel which measures 17 endogenous steroid hormones as well as the synthetic glucocorticoid drug …
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