Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Metaplastic"”.
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The Mechanism of the Gastric Epithelial Stem Cell Response to Metaplastic Injury
<p>Almost nothing is known about the identity of the epithelial stem cell of the gastric corpus, either during normal turnover or in response to injury. Our lab has shown that injection of the selective estrogen receptor modulator tamoxifen leads to near complete atrophy of parietal cells by 3 days …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… and develops carcinosarcoma or metaplastic mammary tumors (70% of all <em>Trim24</em><sup>COE</sup> tumors), a rare and aggressive triple-negative subtype called metaplastic TNBC in humans (MpBC). RNA-sequencing revealed that <em>Trim24</em><sup>COE</sup> mouse mammary tumors …
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P53 Drives A Transcriptional Program That Elicits A Non-Cell-Autonomous Response and Alters Cell State In Vivo
… not <em>p21</em>. Global p53 activation caused a metaplastic phenotype in the pancreas that was missing in mice with acinar-specific p53 activation suggesting non-cell-autonomous effects. The p53 cellular response at single cell resolution in the intestine altered transcriptional cell state …
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Functional role of NMDA receptor subunit composition in metaplasticity
… functional significance of the NR2A subunit in metaplastic changes both in synaptic platicity elicited in vitro and in naturally-occurring platicity in vivo. We also performed a comparison of in vitro methods of inducing plasticity and those which subserve in vivo experience-dependent changes in …
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Potential for change: Characterizing synaptic plasticity following visual discrimination learning in adult rats.
… this thesis provides novel evidence for a metaplastic, training-induced up-regulation of LTP mechanisms in the thalamocortical visual system of adult rats.
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Plasticity of the cortical representation of finger extensors induced by paired associative stimulation
… is a combination of synaptic and non-synaptic (metaplastic) changes. Finally, it is shown that changes in cortical excitability may help modulate certain neurophysiological and clinical features of hand function in a pair of patients with chronic stroke in a pilot study. As expected, stroke …
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ΕΠΙΘΗΛΑΚΗ ΕΚΦΡΑΣΗ ΑΝΤΙΓΟΝΩΝ HLA-DR ΚΑΙ ΛΕΜΦΟΚΥΤΤΑΡΙΚΟΙ ΥΠΟΠΛΥΘΥΣΜΟΙ ΤΟΥ ΓΑΣΤΡΙΚΟΥ ΒΛΕΝΟΓΟΥ ΣΕ ΧΡΟΝΙΑ ΓΑΣΤΡΙΤΙΔΑ ΤΥΠΟΥ - Β: παθογενετική συσχέτιση
… These bacteria were absent in the intestinal metaplastic areas where lymphocytic infiltrates and aberrant HLA-DR expression was minimal. It can be speculated that eithet C-pyloridis bacterial products directly induce, as lectins do, epithelial HLA-DR expression or C-pyloridis absorbed by the …
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Enhanced evaluation of RNA expression in Esophageal Cancer tissues: Combining Microarray and RNA-Sequence approaches
… poor prognoses. Barrett’s esophagus1 (BE), a metaplastic transformation of the normal oesophageal epithelium driven primarily by chronic gastroesophageal reflux, is a recognised precursor lesion for EAC. Together, BE, EAC, and ESCC represent a complex disease spectrum characterised by …
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Trim24 As An Oncogene In The Mammary Gland
… we have observed an over-representation of metaplastic breast carcinomas (MpBC), a rare and devastatingly aggressive disease that has an EMT signature, in profiles of tumors generated in our mouse model. We have performed exome-sequencing, RNA-sequencing and immunohistochemistry on mice, …
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Cellular Ensembles in Alveolar Homeostasis and Repair
… regenerative cells, as well as pathological metaplastic states specifically associated with different forms of damages. The primary alveolar stem cell, alveolar type-2 cells (AT2s) are sparsely distributed and make up only 5% of the surface area. Despite this organization, AT2s are still able …
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Identification of Trim24 Domain Essentiality In Primary Trim24Coe Carcinosarcoma Cell Lines
… and also were reported to recapitulate human Metaplastic Breast Carcinomas (MpBC).</p> <p>Furthermore, in our earlier research on TRIM24 overexpressing mammary cancer epithelial cell lines, our lab also showed that knocking down TRIM24 using siRNA results in significantly impaired cell growth …
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
… Conditional double knockout animals (cDKO) have metaplastic intermediate lobes with impaired localization of adherens junctions proteins including N- and E-cadherin, and beta- and alpha-catenin, and strikingly, infiltration by arginine vasopressin secreting posterior lobe axons. Last, the Sox2 …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… being diagnosed at a late stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could improve outcomes but needs to be balanced with the consequences of over-diagnosis and …