Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Meropenem"”.
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Die Pharmakokinetic von Meropenem bei Patienten mit schweren Infektionen
Meropenem ist ein Carbapenem-Antibiotikum mit breitem Wirkspektrum, guter Verträglichkeit und hoher Gewebepenetration, auch in infiziertes Gewebe. Obwohl Meropenem aufgrund seiner guten pharmakokinetischen und pharmakodynamischen Eigenschaften häufig zur empirischen Therapie kritisch kranker …
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Investigations of the postantibiotic effect and related antibacterial activity of meropenem.
… activity of the carbapenem antibiotic, meropenem. The antibacterial activity of meropenem was determined by establishing minimum inhibitory and minimum bactericidal concentrations when tested against the range of test organisms. The test organisms were all members of the family …
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Development of biosensors for biomarker detection and clinical therapeutic drug monitoring
… for AD detection and the antibiotic drug meropenem (a carbapenem beta lactam drug; 383.46 Da) was developed. The objective was to develop a biosensor capable of capturing the analyte independent of its size. The biosensor was developed to monitor VILIP1 in clinical human samples for the …
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A Study of Antibiotic Resistance Plasmids in Fresh Produce and In Wastewater Environments Using Functional Approaches, Comparative Genomics and Abundance Analysis
… environmental bacteria. Ciprofloxacin, meropenem and erythromycin are important clinical antibiotics due to their broad applications in the treatment of Gram-positive and Gram-negative infections. The capacity to capture, mobilise and control the expression of resistance genes is an …
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Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia
… increase minimum inhibitory concentration of meropenem for P. aeruginosa. There was no effect of TNFα on the overall rate of bacterial adaption to meropenem in any species when measured in vitro. However, in G. mellonella, which represents a complex host environment, elevated concentrations of …
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… (tetracycline, chloramphenicol, vancomycin, meropenem, linezolid, including dual combinations). The new cell-level approach allowed for the first time to simultaneously describe single and combined effects of the aforementioned antibiotics for different experimental protocols, in particular …
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Beyond MICS: Determining the Role of Porin Production and β-Lactamase Expression in Resistance and Cellular Physiology of Klebsiella pneumoniae
… ceftolozane/tazobactam, ceftazidime/avibactam, meropenem, meropenem-vaborbactam, and imipenem-relebactam were determined by E-test using CLSI guidelines. β-lactamase clones were generated by restriction digest cloning. RNA-sequencing of β-lactamase clones and bioinformatics were performed by …
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Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… antibiotics such as piperacillin/tazobactam, meropenem, and cefepime. The objective of this study is to evaluate the population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam, meropenem, and cefepime in hospitalized obese patients in order to determine dosing regimens that …
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Bazı yeni heterosiklik bileşiklerin sentez, yapı aydınlatmaları ve antimikrobiyal etki çalışmaları
… ilaçlar olarak seçilen vankomisin, ampisilin, meropenem, siprofloksasin ve gentamisin ile; antifungal etkileri ise, amfoterisin B ile karşılaştırılmıştır. In vitro aktivite sonuçları incelendiğinde yeni benzimidazol türevlerinin antibakteriyel etkilerinin standart suşlara karşı referans ilaçlardan …
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Investigation of the prevalence of antibiotic resistant bacteria and their genes in wastewater
… detect resistant genes. Penicillin, ampicillin, meropenem and imipenem traces were determined in domestic wastewater and Bacillus cereus isolates were identified. CTX M, TEM and SHV resistant genes were detected. These genes are commonly found in water and are implicated in numerous diseases such …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… of synergy between ceftobiprole and both meropenem and imipenem. Vancomycin, balofloxacin, and floxuridine showed weak synergy. A similar antagonistic effect of mupirocin on ceftobiprole was also observed in other studies showing that it led to β-lactam resistance. We also performed a …
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Características clínicas de pacientes con infección por Clostridium difficile en un hospital de IV nivel Bogotá 2015-2019
… sulbactam, 25% piperacilina tazobactam, meropenem 15%, ertapenem 8,5%, linezolid 5,26% y 3,29% amoxicilina ácido clavulánico. El 85,8% tenían nutrición enteral, 11% mixta y 3,2% parenteral, el 94% consumían inhibidores de bomba de protones. Diabetes mellitus, insuficiencia renal, cardiaca …
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A study of clinical strains of Pseudomonas Aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain PA13
… piperacillin-tazobactam, cefepime, ceftriaxone, meropenem, aztreonam, amikacin, apramycin, butirosin A, lividomycin and colistin sulphate. One of the isolates, PA13, was resistant to a further fourteen antibiotics and was identified as a multidrug resistant strain. A 2.2 kbp PCR product was …
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Developing an antibiogram for empiric antibiotic prescribing for orthopaedic infections in adult patients at a South African tertiary orthopaedic unit
… amikacin and vancomycin or meropenem and vancomycin; 90% of tested isolates were susceptible to either of these combinations. Conclusion Antibiogram profiles can serve to guide to empirical antibiotic choice in the management of different categories of non-spinal orthopaedic …
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Schnelles und zuverlässiges therapeutisches Drug-Monitoring mit HPLC-UV und LC/LC-MS/MS aus komplexen Matrizes
… HPLC- und eine LC-MS-Methode entwickelt. Mit Meropenem wurde eine Pharmakokinetik-Studie zum Vergleich zweier Infusionsregime durchgeführt. Eine bisher unbekannte Arzneimittelinteraktion zwischen Linezolid und Rifampicin wurde entdeckt. <br>Mit dieser Arbeit wurden erstmalig vollautomatische …
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Detection and characterisation of carbapenem-resistant gram-negative bacilli infections in Ghana
… isolates showed complete resistance to imipenem, meropenem and ertapenem at ≥32 μg/ml, of which 24.3% were found in Pseudomonas aeruginosa isolates and 18.9% in Acinetobacter baumannii isolates. In all, no KPC-1 and IMP-1 genes were detected. Carbapenemase genes identified were blaNDM-1 in …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… and carbapenems (such as imipenem and meropenem) represent important treatment options for infections caused by this microorganism. Nevertheless, the number of strains resistant to these antibiotics has been increasing during the last decade. The ability to capture, mobilise and …
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Pseudomonas aeruginosa: estudo epidemiológico e da ação do óxido nítrico sobre biofilmes de amostras mucoides de pacientes com fibrose cística
… a P. aeruginosa foram Amicacina, Imipenem, Meropenem e Aztreonam. Biofilmes de amostras mucóides da P. aeruginosa são muito mais complexos se comparados aos das amostras não-mucóides. No primeiro caso, as bactérias se agregam em estruturas que lembram teias de aranha que se fixam ao …
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