Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Memantine"”.
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The Protective Effects of Memantine On The Morphology and Activity of Irradiated Dendritic Spines
<p><strong>Abstract: The Protective Effects of Memantine on the Morphology And </strong></p> <p><strong>Activity of Irradiated Dendritic Spines</strong><strong></strong></p> <p>Thanh T. Lam, M.S.</p> <p>Advisory Professor: David R. Grosshans, M.D, Ph.D.</p> <p>Although radiotherapy is an effective …
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Causal Inference Methods for Estimation of Survival and General Health Status Measures of Alzheimer’s Disease Patients
… of Alzheimer’s disease drugs, Donepezil and Memantine, and their combined use on Survival and General Health Status Measures of Alzheimer's disease patients for the first five years after initial diagnosis. We carried out a thorough causal inference study using doubly robust estimators, …
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Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder
… effects without the potential side effects. Memantine is a NMDAR antagonist similar to ketamine in many regards but does not produce antidepressant effects in patients. Behavioral experiments in mice recapitulated clinical findings showing that ketamine but not memantine has …
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Repurposing Alzheimer’s disease medications in a drug combination for the study of the crosstalk between cell apoptosis and autophagy in the modulation of cell death in chronic myeloid leukaemia
… but low concentrations (1, 5 and 10 μM) of Memantine and Donepezil (AD drugs) were shown to be non-toxic in this study, as they induced no measurable cell death in both cell lines tested, with Memantine (1 μM) increasing the viability of HEK293T (the AD cell model) by 41% (p < 0.05). …
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Markers of Prognosis in Neurodegenerative Dementia
… shortest survival. IV. Patients, who received memantine instead of placebo during the first 6 months of follow-up, had a longer length-of survival. Patients, who responded positively to memantine lived longer compared to the non-responders. Conclusions: This thesis adds to current knowledge by …
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The effect of Alzheimer's disease on cortical microcircuits
… licenced medication for Alzheimer’s disease, memantine. To do this, I use magnetoencephalography data recorded during mismatch negativity paradigms from (1) neurologically-healthy people from a double-blind placebo-controlled crossover study of the NMDA antagonist memantine and (2) people with …
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Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy
… pigment epithelial (RPE) cells. Another drug memantine is reported to prevent the neurodegeneration in DR by blocking the overexcitation of N-Methyl-D-aspartate (NMDA) receptors. Thus, the simultaneous administration of both the drugs would provide a complete neurovascular treatment for DR as …
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Phantomschmerz: Prothetik und neue medikamentöse Behandlung
… Durch die Gabe des NMDA-Rezeptor-Antagonisten, Memantine, konnte in einer kontrollierten Behandlungsstudie im Doppel-blind-crossover-design der Phantomschmerz gegenüber der Placebobehandlung signifikant verringert werden.
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Neuroinflammation, Glutamate Regulation and Memory
… preliminary data on delayed treatment with memantine, a drug which reduces post-synaptic glutamate function that is used for AD (Chapter 4). Like the basal ganglia and brainstem, I found compensatory recovery in hippocampal function over time, despite continued neuroinflammation, as revealed …
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Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease
… accepted by FDA, Food Drug administration, that memantine, an uncompetitive NMDA antagonist as a Cognition-enhancing medication. The molecular mechanism of memantine (MEM) is the blockade of glutamate, the principal excitatory neurotransmitter, at NMDA receptors.</p> <p>It was proposed that the …
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Vascular action of glycine in hypertensive rat models
… and absence of two NMDA antagonists, MK-801 and memantine. In normotensive WKY rats, glycine (1 mmol/L) administration decreased MAP (P
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… using well-established NMDAR antagonists (memantine, MK-801, AP5 and riluzole) and agonists (glutamate and NMDA). Cells from patients with megakaryocytic cancers were also used to confirm NMDAR expression. The second part of this thesis used normal mouse megakaryocytes in primary cultures …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… antagonist, AP5, or open channel blocker, memantine, effectively blocked it. Support for these findings was further demonstrated by the ability of preconditioning with NMDA itself to neuroprotect from Aβ-insult directly.</p><p>MEP was then shown to modulate NMDAR by increasing receptor …
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Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease
… of acetylcholinesterase inhibitors (AChEIs), memantine and monoclonal antibodies. However, these drugs provide only symptomatic relief and do not prevent progressive neurodegeneration. Among the above-mentioned approved drugs, AChEIs are suggested to have the ability to inhibit the synthesis, …