Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 52 for “"MeCP2"”.
-
A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
Methyl CpG binding protein 2 (MeCP2) was originally characterized as a transcriptional repressor that preferentially bound methylated DNA, however, recent data indicates MeCP2 is a multifunctional protein. MeCP2 is now shown to associate with expressed genes as well as repressed genes indicating …
-
MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… repressor methyl-CpG-binding protein 2 (MeCP2), lead to a form of mental retardation called Rett Syndrome (RTT). Though the MeCP2 protein is expressed ubiquitously, symptoms of RTT patients are primarily neurological, which include reduced mental capacity, autistic-like behavior and …
-
Biochemical, biophysical and structural study of the nucleosome-MeCP2 complex
Methyl-CpG Binding Protein (MeCP2) is an abundant chromatin associated protein that is important in maintaining human health; mutations in this protein cause Rett Syndrome, a neurodevelopmental disease that is a common cause of mental retardation and autism in females. MeCP2 was initially …
-
Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… that the methyl-CpG-binding protein 2 (MeCP2) contributes to both neural and behavioral adaptations induced by repeated psychostimulant exposure (Deng et al, 2010, Im et al, 2010). Psychostimulants induce rapid and robust phosphorylation of MeCP2 at Ser421 (pMeCP2), a site that is …
-
DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
… en dos factores con funciones diferentes: MeCP2, una proteína de unión a ADN metilado, y DDX47, una helicasa de ARN localizada en el nucléolo. El silenciamiento de MECP2 da lugar a un aumento de híbridos a nivel global en el nucleoplasma y en concreto, en genes con altos niveles de híbridos …
-
Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
… regulator and methylation associated protein MeCP2 in prostate cancer cells and other cancer cell types. We observed that both proteins regulate the expression of the heat shock protein 27 gene by transactivating its promoter region. We propose that the interaction between LEDGF/p75 and MeCP2 …
-
Creation and establishment of transgenic mouse models for for Mecp2 gene, causing Rett syndrome
Das MeCP2 Protein ist ein transkriptonaler Repressor, der an methylierte Cytosine bindet und die Chromatinstruktur modifiziert. Mecp2 ist für 95% aller Rett-Syndrom-Fälle verantwortlich. Trotz der ubiquitären Expression von MeCP2 wird angenommen, dass es einzigartige Funktionen in Neuronen hat. …
-
Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
… the X-linked gene, methyl-CpG-binding protein 2 (MECP2). After a period of seemingly normal post-natal development, RTT patients experience a developmental regression, consisting of loss of acquired verbal and motor skills, stereotypic hand movements, respiratory abnormalities, and seizures. …
-
The Role of MeCP2 and FoxG1 in Embryonic Cortical Development: Implications for Autism Spectrum Disorders
… and have been implicated in ASDs are FOXG1 and MECP2. Mutations in FOXG1 cause a rare neurodevelopmental disorder known as FOXG1 syndrome, which presents with autistic features, microcephaly, and severe intellectual disability. Similarly, mutations in MECP2 cause Rett syndrome, another severe …
-
MUSCLE-SPECIFIC MECP2 MISEXPRESSION INDUCES SKELETAL AND VISCERAL MUSCLE DEFECTS RESCUED BY BUTYRATE SUPPLEMENTATION IN DROSOPHILA
Summary Background MeCP2 is a chromatin-associated protein whose dosage alterations cause two severe neurodevelopmental disorders: Rett syndrome (RTT), linked to loss-of-function mutations, and MECP2 duplication syndrome (MDS), linked to overexpression. Although widely studied for their …
-
Exploring induced secondary structure and unmethylated DNA binding domains of methyl CpG binding protein 2 (MeCP2)
… understanding of Methyl CpG binding protein 2 (MeCP2) structure and function has changed and expanded considerably over the last two decades. Mutations along the entirety of the human MeCP2 gene product lead to a disease state - Rett syndrome. The clinical connection of this protein has …
-
Vitamin D Modulates Rett Syndrome Phenotypes and Underlying Cellular Pathways in an Mecp2-mutant Mouse Model
… by mutations in the transcriptional regulator MECP2. There is currently no effective treatment for RTT. Female RTT patients develop relatively normally during the first 6-18 months of life, after which they undergo a period of rapid regression, losing the ability to talk, walk and purposefully …
-
Quantitative Genexpressionsanalyse im respiratorischen Netzwerk an Mausmodellen für das Rett-Syndrom
… Das Rett-Syndrom wird durch Mutationen im MECP2-Gen hervorgerufen. Sowohl der Verlust als auch die Duplikation des MECP2-Gens bewirken eine Rett-Symptomatik beziehungsweise eine, die ähnlich der Rett-Symptomatik ist. Das sich auf dem X-Chromosom befindende MECP2-Gen kodiert für den …
-
Developmental trajectory of functional neocortical networks in an in vitro mouse model of Rett syndrome
… disorder caused by loss-of-function MECP2 mutations, affecting ~1 in 10,000 female births. RTT causes progressive impairments in early life and has no cure. Despite known genetic origin in RTT, the mechanisms by which MECP2 mutations disrupt brain function is poorly understood. …
-
Characterizing interactions between cAMP responsive element binding protein 1 and methyl-CpG-binding protein 2 as a potential transcriptional activation complex
… are proteins like methyl-CpG-binding protein 2 (MeCP2). MeCP2 regulates transcription by binding to methylated DNA. MeCP2 is traditionally associated with being a transcriptional repressor by binding to methylated CpG dinucleotides and recruiting corepressors. Literature has shown that MeCP2 is …
-
THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
… coding for the methyl-CpG binding protein 2 (MeCP2). It is an important epigenetic regulator that is ubiquitously expressed and particularly abundant in brain and important for proper neuronal maturation and function. In fact, MeCP2 deficiency in neurons is responsible for impairment of …
-
NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… by severe loss of function mutations in the MECP2 gene encoding for the methyl-CpG binding protein 2 (MeCP2), an epigenetic factor involved in gene transcription regulation and chromatin remodeling, particularly abundant in the central nervous system. RTT features include cognitive and motor …
-
Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development
… the gene encoding methyl CpG-binding protein 2 (MeCP2), which is expressed in the brain during prenatal neurogenesis and continuously throughout adulthood. MeCP2 is a pleiotropic gene that functions as a complex, high-level transcriptional modulator. It both regulates and is regulated by coding …
-
Contextual Insights into the Rett Syndrome Transcriptome
Mutations in MECP2 are responsible for Rett syndrome (RTT), a severe X-linked neurological disorder characterized by loss of developmental milestones, intellectual disability and motor impairments. However, molecular insight into how these mutations affect the neuronal transcriptiome, disrupt …
Page 1 of 3