Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"Matrix stiffness"”.
-
Matrix Stiffness Regulates Glial Cell Morphology and Differentiation
… the ability of cells to sense and respond to the stiffness of the surrounding extracellular matrix (ECM). In the PNS, the ECM consists of a dense SC-secreted basal lamina, which displays significantly higher rigidity than the more loosely organized CNS matrix. </p> <p>In order to evaluate whether …
-
Pan-Cancer Analysis of RNA Dysregulation, Somatic Mutations, and Matrix Stiffness using Bioinformatics Approaches
… designed a computational model to predict tumor matrix stiffness using RNA-seq data, uncovering how matrix stiffness influences tumor complexity, immune infiltration, and extracellular matrix alterations. These findings provide a deeper understanding of the molecular and biophysical …
-
Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple …
-
Investigating the Interplay between Inflammation and Matrix Stiffness: Evaluation of Cell Phenotype and Cytoplasmic Stiffness In Vitro
… and mechanical properties of the extracellular matrix (ECM), signaling molecules secreted by cells into their surroundings, as well as physical interactions between neighboring cells. Cells are able to interact with their surroundings through a number of different mechanisms such as remodeling …
-
Angiogenic growth factors and notch signaling regulate liver sinusoidal endothelial cell phenotype in combination with matrix stiffness and ECM composition
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Extracellular matrix stiffness and geometry: The impact on static and dynamic cellular systems in vitro and the treatment of tissue ischemia
… how main cell functions can be controlled by the matrix mechanical properties, with a goal to emulate physiological processes in vitro and potentiate stem cell treatments with appropriate bio-matrix design. First, I describe a method to promote advanced cardiomyogenic and endothelial …
-
Study of base isolation systems
… building lateral system was designed using the matrix stiffness calibration method and modal analysis was employed to compare the intended period of the structure with the results from computer simulations. Base isolation proves to be effective in reducing the induced inertia forces on a …
-
Biomimetic Extracellular Matrices for In Vitro Cancer Models and Tissue Engineering Platforms
… hydrogels, (ii) independently controlling matrix stiffness from other matrix properties, and (iii) generating structurally anisotropic networks. As nanofibrillar hydrogels scatter light and strongly interfere with the optical characterization of cells, the first project describes the …
-
Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… is employed to systematically explore the stiffness-responsive transcriptome of MSCs. High matrix rigidity impedes integrin-collagen adhesions which yields changes in cell morphology that are characterized by a contractile network of actin proximal to the cell membrane. This results in a …
-
Matrix-mediated formation & innervation of skeletal myotubes
… to study the role of a variety of extracellular matrix properties on skeletal muscle formation and, ultimately, innervation. The role of polysaccharide mediated pores will be investigated in Chapter 2. Myogenic differentiation will be decoupled from matrix stiffness in an aligned microchanneled …
-
The Role of Biomechanics in Liver Tissue Engineering
… that retain the native tissue's extracellular matrix and architecture. These scaffolds can then be repopulated with a variety of hepatic and non-hepatic cell-types depending on the application, or in the case of human transplantation, the patient's own cells. While there has been some success …
-
Enzymatic crosslinking of dynamic hydrogels for in vitro cell culture
Stiffening and softening of extracellular matrix (ECM) are critical processes governing many aspects of biological processes. The most common practice used to investigate these processes is seeding cells on two-dimensional (2D) surfaces of varying stiffness. In recent years, cell-laden …
-
Development of orthogonally crosslinked thiol-ene hydrogels for encapsulation of pancreatic beta-cells
… it is essential to identify a suitable gel stiffness to support the viability and functions of β-cells. To this end, a thiol-allylether hydrogel with on-demand tunable matrix stiffness was developed. Specifically, host molecule βCD was immobilized in the hydrogel network to provide binding …
-
The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… into intracellular biochemical responses. The stiffness of the matrix influences numerous processes such as cell differentiation, cell migration, fibrosis, and tumorigenesis. Stiffness is sensed by matrix-binding receptors and transmitted through the cytoskeleton by actomyosin contractility. …
-
Endothelial cell response to bioactive peptides and stiffened extracellular matrices: an investigation into atherogenic pathways
… into whether endothelial cells grown on varying matrix stiffness would experience mechanical forces resulting in cellular responses more indicative of in vivo conditions. Polyacrylamide (PAC) gels of varying stiffness (2.5, 3, 10 and 30kPa) were prepared, and cell growth characteristics and …
-
The interplay of matrix rigidity and mechanical stretching for the development of artificial skin
… counterparts which leads to failure in vivo. Matrix rigidity and mechanical forces are key regulators of tissue homeostasis and are essential for tissue formation, remodeling and healthy function. As a consequence, mechanical stimulation has frequently been employed to improve tissue …
-
Engineered N-cadherin substrates for stem cell differentiation
… cells using soluble factors and cell adhesion matrix properties. These differentiation studies are often dependent on the density of cells plated on the substrate, which implies that there is an important role of cadherin-modulated cell-cell adhesion in regulating stem cell differentiation …
-
Energy-absorption capability of composite tubes and beams
… For example, an increase in fiber and matrix stiffness and failure strain can, depending upon the configuration of the tube, increase energy-absorption capability. An analysis to predict the energy-absorption capability of composite tube specimens was developed and verified. Good …
-
Effects of Liver Extracellular Matrix Gel Stiffness on Primary Hepatocyte Function
The extracellular matrix is a complex environment of mechanical and chemical cues vital to individual cell growth, tissue formation, and ultimately complete organ function. The field of regenerative medicine aims to recreate the unique biological properties found in specific tissue types and to …
-
Micro/nanoscale modeling of anisotropic mechanical properties of polymer/layered-silicate nanocomposites
… geometrical parameters as well as particle and matrix stiffness parameters through FEM simulations. Effective properties of intercalated clay particles have been estimated in terms of characteristic clay structural parameters (interlayer spacing and number of layers), with additional information …
Page 1 of 2