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Showing 1 to 13 of 13 for “"Machine Perfusion"”.
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Hypothermic Machine Perfusion of Composite Tissues
Organ perfusion systems have successfully been applied to solid organ preservation and subsequent transplantation. However, their use in limb preservation for Vascularized Composite Tissue Allotransplantation (VCA) has yet to be thoroughly investigated. This thesis explores the potential for …
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Studies of normothermic machine perfusion in human kidney transplantation
Normothermic machine perfusion (NMP) of human kidneys is a new preservation technique that allows for the assessment and treatment of kidneys prior to transplantation. However, there is currently no standard protocol for NMP of kidneys and limited understanding of the underlying mechanisms that …
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Quantifying Renal Swelling during Machine Perfusion using Digital Image Correlation
While machine perfusion of explanted kidneys is theoretically superior to standard cold storage, it may damage potential transplants unless machine-associated swelling is controlled. This thesis presents the effects of perfusate tonicity on renal swelling during hypothermic machine perfusion. …
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Examining the regional physiology of the transplant kidney during normothermic machine perfusion.
Ischaemia-reperfusion injury (IRI) is an unavoidable consequence of deceased-donor kidney transplantation that has a profound effect upon both immediate and long-term graft function. Disruption to microvascular perfusion (MVP) and tissue oxygenation (PtO2) are central to the development of IRI, but …
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Perfusion Solution Optimization by Substrate Alteration and Nanoparticle Delivery for Cardiac Hypothermic Machine Perfusion
Pages vi-xviii are misnumbered as vii-xix.
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Optimizing the delivery of pre-transplantation therapies during normothermic machine perfusion of human kidneys
… have an increased susceptibility to ischemia reperfusion injury and the use of these organs may ultimately result in post-transplant complications like graft loss and recipient death. Normothermic machine perfusion has emerged as a platform for ex vivo assessment and repair to increase …
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Spectroscopic Technologies and Computational Approaches for Real-Time Detection of FMN as Biomarker during Machine Perfusion
… but in recent years a new technique has emerged: machine perfusion. This approach consists of perfusing the organ with an oxygenated solution, either acellular or blood-based, with the aim of reactivating aerobic metabolism prior to transplantation and enabling the assessment of organ viability …
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OXYGEN DELIVERY AND CONSUMPTION DURING HYPOTHERMIC OXYGENATED MACHINE PERFUSION AND THEIR IMPACT ON POST-LIVER TRANSPLANT OUTCOME.
… garantire un’adeguata ossigenazione durante la perfusione ipotermica epatica ossigenata con macchina (HOPE), studi recenti hanno evidenziato come l’aumento della produzione di anidride carbonica (CO2) sia associato a un maggior danno del graft. Obiettivo di questo studio è analizzare la …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… implantation (static storage). A new technique (machine perfusion preservation) is under development and works by perfusing the organ with oxygenated preservation solution. This method may extend the donor ischemic interval and may permit utilization of less-than-optimal donor hearts - thus …
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Enzymatic blood group conversion of human kidneys for transplantation
… with ex vivo normothermic and hypothermic machine perfusion technologies to produce enzyme converted (ABOe) blood group O kidneys. Firstly, an a-galactosidase enzyme from *Bacteroides fragilis* was used to remove blood group B antigens from human tissue *in vitro* and *ex vivo* in Chapter …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
Ischaemia-reperfusion (IR) injury makes a major contribution to graft damage during kidney transplantation and increases the risks of primary non-function, delayed graft function and rejection. Oxidative damage to mitochondria is a key early event in IR injury. The aim of this project was to …
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Marginal donor characteristics and outcomes after liver transplantation
… on a graft already exposed to some ischaemic reperfusion injury. Care was taken when designing statistical analysis to choose variables which were either significant on univariable analysis or important in the literature to allow a condensed model to be chosen and to optimise the fit and …