Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22000 for “"MS"”.
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Entwicklung von Screeningverfahren für Arzneistoffe und Metaboliten mittels LC-MS und LC-MS/MS
Zunächst wurde ein LC-MS Screeningverfahren weiterentwickelt basierend auf einer bereits existierenden Screening Methode auf körperfremde Substanzen mit einer ESI-CID Massenspektrenbibliothek. Diese Bibliothek musste neu erstellt werden wegen Umstellung von der Software-Version eines Macintosh …
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Studium nových syntetických drog metodou LC/MS/MS
… mefedron včetně jeho metabolitů metodou LC-MS/MS. Byl studován standard, negativní moč s přídavkem mefedronu a reálný vzorek moči potkana, kterému byl podán mefedron. Ve vzorku moči byl detekován mefedron a některé jeho metabolity. Získané informace o zkoumaných látkách mohou být následně …
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CE-microreactor-CE-MS-MS for protein analysis
Capillary electrophoresis-mass spectrometry (CE-MS) provides a powerful system that combines the speed and automation capabilities of CE with the detection and identification capabilities of MS. Integrating on-line enzymatic microreactor digestion with a CE-MS system reduces sample handling and …
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Optimized GeLC-MS/MS for Bottom-Up Proteomics
… and body fluid proteomes in different organisms remains a challenging task due to the complexity of the samples and the wide dynamic range of protein concentrations. In addition, large amounts of produced data make result exploitation difficult. To overcome these issues, further advances in …
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Ms. Linto
Ms. Linto is inspired by a famous Taiwan legend called Ms. Linto. This story happened in Tainan. Linto who is a widow and raises three kinds alone, was tricked out of her life saving by a smooth talking handsome man, ACSi Chou, who had promised to marry her. Later, two of her older kids either die …
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Innleiðing einnar mæliaðferðar á LC-MS/MS fyrir átján sterahormón
… chromatography tandem mass spectrometry (LC- MS/MS). Today LC-MS/MS is considered a gold standard for steroid hormone measurements. LC- MS/MS technique is both quantitative and qualitative and able to quantitate very low concentrations of analytes and determine complex molecule structures. The …
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Biomarker analysis for APRT deficiency diagnosis using UPLC-MS/MS
… enzyme is absent, adenine is oxidized and forms 2,8-dihydroxyadenine (DHA). DHA is insoluble in urine and can precipitate and form kidney stones, which can cause acute and chronic kidney failure. The disease can be treated with the drugs allopurinol and febuxostat, which prevent the conversion …
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Understanding MS/MS fragmentation pathways of small molecular weight molecules
… is not well-understood, making interpretation of MS/MS spectra difficult and limiting the effectiveness of software tools intended to aid mass spectral interpretation. An approach is required which is tailored to each individual molecule and improves the ‘chemical sense’ of the software. It was …
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Computational Analysis of LC-MS/MS Data for Metabolite Identification
Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on high-resolution, high-accuracy mass spectrometers enables …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… prevalent post-translational modifications (PTMs) is protein glycosylation, which enhances several biological functions, such as protein stability, localization, cellular communication, inflammation, immune responses, and host-pathogen interactions. Unusual protein glycosylation has been linked …
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Determination of Carbon Nanotube Modification by TG-MS and Pyrolysis-GC/MS
… were thermogravi me try-mass spectrometry (TG-MS) and pyrolysis-gas chromatography/mass spectrometry (GC/MS). Samples were heated while the gasses evolved were monitored to determine their identities. The soluble SWNTs were less stable than the non-soluble SWNTS. In addition, they also had much …
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Resíduos de glyphosate em grãos de café determinados por LC- MS/MS
… acoplada à espectrometria de massas tandem (LC-MS/MS) (Capítulo 1). Em sequência, esse método foi aplicado em um estudo a campo para avaliar a possível contaminação de grãos de café verde após a aplicação do glyphosate em diferentes estágios de desenvolvimento da cultura do café (Capítulo 2). …
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Novel Applications of Top Down MS/MS for Interrogating the Human Proteome
Top Down MS analysis of proteins from human cervical carcinoma cell lines and primary human leukocytes harvested from leukoreduction filters provided identification of 261 protein forms, with ∼12% overlap between the two proteomes. The protein forms were produced by 162 unique genes (∼22% …
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Alkalmazhásfejlesztés MS ACCES-ben
Egy adatbázis alkalmazás fejlesztése szép és komoly feladat. Látni, amikor a számítástechnikában nem annyira járatos felhasználónak is elnyeri a tetszését: elismeri, hogy megkönnyíti a munkáját nincs is jobb érzés. De ne feledjük, hogy egy alkalmazás sohasem lehet teljesen kész, tökéletes. Mindig …
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Computational Tools to Expand the Coverage of Metabolite Profiling via LC-MS/MS
… the common metabolite profiling technologies, LC-MS/MS, and takes two steps to expand the coverage of current metabolite profiling experiments.</p><p>First, a method to enable collection of MS/MS data from a greater portion of the detected ions is presented. This is done by collecting …
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Protein Biomarkers of Ionizing Radiation and Standardization by MALDI MS/MS and Quantification
… called a lateral flow device, to triage victims of a radiological dispersal device or nuclear detonation. Mice were radiated with 2 Gy, 4 Gy and 7 Gy and sacrificed at 1 hour, 24 hours and 72 hours. Also, mice were injected with lipopolysaccharide (LPS) endotoxin (10 ?g) to induce an …
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classCleaner: A Quantitative Method for Validating Peptide Identification in LC-MS/MS Workflows
… chromatography-tandem mass spectrometry (LC-MS/MS) shotgun proteomics infers the peptide sequence of each measurement, there is inherent uncertainty in the identity of each peptide and its originating protein. Removing misidentified peptides can improve the accuracy and power of downstream …
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ANALYSIS OF PHARMACEUTICALS AND BIOMOLECULES USING HPLC COUPLED TO ICP-MS AND ESI-MS
… thesis explores the use of HPLC coupled with ICPMS and ESI-MS in order to develop novel methods which overcome specific analytical challenges in the pharmaceutical industry. A membrane desolvation interface has been evaluated for coupling high performance liquid chromatography (HPLC) with …
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