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Showing 1 to 20 of 23 for “"MMP-3"”.

  1. Nfat1 Contributes to Melanoma Tumor Growth and Metastasis By Regulating Il-8 and Mmp-3

    Shoshan, Einav2016

    … two downstream targets of NFAT1, i.e; IL-8 and MMP-3 to be downregulated following silencing NFAT1. While silencing of NFAT1 reduced IL-8 and MMP-3 in highly metastatic cell lines, A375SM and WM902B, overexpression of NFAT1 in the low metastatic cell line, SB2 induced the expression of both IL-8 …

    uthsc Repository record

  2. Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.

    김, 광수2011

    Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matix (ECM) components during normal and pathogenic condition. Documented expression of MMPs contributes to tissue remodeling, atherosclerosis, and inflammatory diseases. MMPs are tight regulated by …

    ajou Repository record

  3. Extracellular Matrix Degradation and Mechanical Integrity of Degenerated Human Annulus Fibrosus from Surgical Specimens

    Salaam, MohammedGraduate Studies2026

    … early disease. Western blot analysis showed that MMP-3 abundance rose significantly with age in asymptomatic tissue but continued to rise progressively in IVDD, indicating divergent regulated versus dysregulated proteolytic trajectories in aging versus disease. HTRA1 was constitutively expressed …

    calgary Repository record

  4. Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα

    Σταθάς, Θεόδωρος2013

    … παραγωγή διαμεσολαβητών, όπως η IL-6 η MMP-1, η MMP-3 το κολλαγόνο τύπου-Ι και ο TIMP-1, που εμπλέκονται στη παθογένεια του ρινικού πολύποδα (ΡΠ). Ο MIF ανιχνεύθηκε στο μέσο καλλιέργειας όλων των ιστών και σε όλα τα εκχυλίσματα. Η έκφρασή του ήταν αυξημένη στον ρινικό πολύποδα σε σχέση …

    patras-thes Repository record

  5. Investigation on the Molecular Mechanism of Photorejuvenation in Photodynamic Therapy

    김, 수경2014

    … induced increase of matrix metalloproteinase (MMP)-3 and collagen type Iα through prolonged activation of extracellular signal–regulated kinase (ERK). Increased MMP-3 may induce breakage of old collagen and allow new collagen synthesis. PURPOSE: In this study, I investigated molecular mechanism …

    ajou Repository record

  6. Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy

    장, 용현2011

    … in other treatments. Matrix metalloproteinase (MMP)-1 and MMP-3 mRNA by real-time PCR significantly increased in PDT group compared with control group showing a maximal increase 24 h following PDT. TGF-β mRNA increased in PDT group at 6, 12 h post-PDT. Collagen Iα1 mRNA levels also increased …

    ajou Repository record

  7. The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.

    Dunn, Sara Louise.Sheffield Hallam University (United Kingdom).2013

    … proteases including matrix metalloproteinases (MMPs). Cannabinoids have been shown to reduce joint damage in animal models of arthritis and have also been shown to prevent IL-1 induced matrix breakdown of collagens and proteoglycans, suggesting a chondroprotective effect of these compounds. …

    sheffield-hallam Repository record

  8. Bedeutung von DNS-Polymorphismen bei Arthrose

    Eden, LarsUniversität Würzburg

    … haben: Il-1 alpha, Il-1 beta, TNF alpha und MMP-3 (Stromelysin). Viele bereits durchgeführte Studien lieferten widersprüchliche Ergebnisse, wiesen zu geringe Fallzahlen auf oder definierten die Kollektive nur unzureichend. Ziel dieser Studie war es klar definierte Kollektive mit möglichst …

    wurz-thes Repository record

  9. Role of the CD40 receptor/CD154 ligand dyad in the control of smooth muscle cells phenotype

    Stojakovic, Milica2012

    … Expression der Matrixmetallprotease-3 (MMP-3) gewählt. Mit Hilfe spezifischer Inhibitoren konnte gezeigt werden, dass die Tyrosinkinase c-Src und die Mitogen-aktivierte Kinase p38 an der CD40-induzierten MMP-3-Expression beteiligt sind. Außerdem konnte gezeigt werden, dass der durch …

    goettingen Repository record

  10. Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes

    Lucero, JacquelynnTexas Woman's University2019

    … degrading enzyme, matrix metalloproteinase-3 (MMP-3). In conclusion, these findings suggest that TCP promote cartilage health by modulating pro-inflammatory pathways implicated in extracellular matrix destruction, as indicated by the effect of TCP doses on nitrite, iNOS, and YKL-40 levels. …

    twu Repository record

  11. Vergleichende Untersuchungen zum Effekt von Interleukin-17A auf den Meniskus und hyalinen Gelenkknorpel im Rindermodell

    Ahrens, GretaChristian-Albrechts-Universität zu Kiel

    … der mRNA-Level matrix-degradierende Enzyme (MMP-3, -13 und ADAMTS-4) und gewebespezifischer Kollagene (Kollagen-1 und-2) (qRT-PCR) und lichtmikroskopisch die Apoptoserate eruiert. Zusätzlich wurde das Gewebe lichtmikroskopisch mit einer Toluidinblaufärbung und der Aggrekanabbau mittels …

    cau-kiel Repository record

  12. The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier

    현, 수왕2015

    … claudin-5, increase of matrix metalloproteinase (MMP)-3/9 mRNA levels, and translocation of Forkhead box O 3a (FoxO3a) into nucleus. The effects of antioxidant, trolox, and N-acetyl-cysteine (NAC) as well as siFoxO3a transfection also mimicked those effects of OE, Quer, YE, and HSP. However, …

    ajou Repository record

  13. Meniscectomy & osteoarthritis

    Pengas, IoannisUniversity of Dundee2012

    … with regards to biomarkers of OA in the form of MMP-3 and GAG. Neither serum nor synovial MMP-3 demonstrated any significant correlation with other measured parameters. GAG on the other hand demonstrated a significant difference between the index and non-index knee as well as a positive …

    dundee Repository record

  14. Imagerie moléculaire de la MMP-2

    Lebel, RéjeanUniversité de Sherbrooke2012

    Les métalloprotéinases de matrice (MMPs) sont des enzymes impliquées dans la restructuration tissulaire et la migration cellulaire. La MMP-2, en particulier, a été reconnue comme biomarqueur de la progression ou du pronostic de plusieurs pathologies, comme l'arthrite, l'athérosclérose, l'infarctus …

    sherbrooke Repository record

  15. Expression and secretion of basigin by human placental trophoblast cells occurs via microvesicle shedding and is a regulated process

    Ermilova, ViktoriyaUniversity of Illinois at Urbana-Champaign2012

    … many factors such as matrix metalloproteinases (MMPs), as well as cytokines, growth factors and oxygen tension. Previous studies have demonstrated that basigin (BSG)/extracellular matrix metalloproteinase inducer (EMMPRIN) is able to regulate MMP production and is critical for successful …

    uiuc Repository record

  16. Μελέτη της έκφρασης και του ρόλου της σεργλυκίνης στις κακοήθειες

    Κορπετίνου, Αγγελική2014

    … του εξωκυττάριου χώρου, όπως οι tPA, uPA, MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP και του αναστολέα των μεταλλοπρωτεϊνασών TIMP-1. Παρουσιάσθηκε ότι η υπερέκφραση του πλήρους μορίου της SG αλλά και της μη γλυκοζυλιωμένης της μορφής οδηγούν στη διαφοροποίηση της έκφρασης και της ενεργότητας των …

    patras-thes Repository record

  17. The Role of Tumor Necrosis Factor-Stimulated Gene 6 Protein (TSG-6) in Osteoarthritis

    Chou, Chingheng2017

    … reactants TIMP-1, A2M, VEGF, VCAM-1, ICAM, MMP-3, TNFR2, cytokines IL-6, IL-8, IL-18, quantity of activated macrophages in synovium and soluble macrophage-associated marker CD14 and number of low molecular weight (pro-inflammatory) hyaluronan (HA) molecules. Moreover, TSG-6 impaired …

    duke Repository record

  18. In Vitro Equine Flexor Tendonitis: New Model Development and Therapeutic Investigation

    Cissell, James MichaelVirginia Tech2009

    … gene expression for matrix metalloproteinases (MMP)-1, MMP-3, and MMP-13, collagen types I and III, and the non-collagenous proteins cartilage oligomeric matrix protein (COMP) and decorin. Data will be analyzed by analysis of variance and post-hoc comparisons. Significance will be set at p<0.05. …

    vt Repository record

  19. Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes

    Can, VediaUniversity of Westminster2024

    … inhibited pro-inflammatory mediator (IL-6, IL-8, MMP-1, MMP-3 and MMP-13) release determined by ELISA. The selective hMC3 receptor agonist PG-990 also displayed protective effects on glycosaminoglycan content and induced HO-1 expression. Whereby, the selective hMC1 receptor agonist BMS-470539 …

    westminster Repository record

  20. The effect of freeze dried whole blueberries on pain, gait performance and inflammation in individuals with symptomatic knee osteoarthritis

    Du, ChenTexas Woman's University2018

    … IL-6, IL-10, IL-13, matrix metalloproteinases (MMP)-3, and MMP-13, in the blueberry group. However, significant increases in TNF-α and IL-1β were noted at midpoint over baseline in the placebo group. Weight and BMI were significantly increased in the placebo group, while individuals in the …

    twu Repository record

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