Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"MITF"”.
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Melanomspezifische Genexpression und Signaltransduktion bei Xiphophorus: Die Rolle des Transkriptionsfaktors Mitf
… “microphthalmia associated” Transkriptionsfaktor Mitf-M spezifisch in Melanozyten und Melanomzellen exprimiert wird, scheint er eine wichtige Rolle in der melanomspezifischen transkriptionellen Aktivierung zu spielen und war deshalb im Rahmen dieser Arbeit näher untersucht worden. Das Xiphophorus …
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Establishment of MITF and TAZ as major determinants of uveal melanoma
… well established that CM tumors are dependent on MITF, the master melanocyte transcription factor. Here, in stark contrast, we establish that MITF serves as a tumor suppressor in an oncogenic GNAQ/11 UM zebrafish model. Moreover, we show that resulting MITF-deficient tumors are more …
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Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
… Microphthalmia associated transcription factor (Mitf) are downregulated in embryonic and adult mutant pancreata. In contrast, the mRNA level of Retinol Binding Protein-4 (Rbp4) was upregulated in mutant tissue. Given the differences in spatio-temporal expression pattern of MafA and MafB in …
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Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models
… and contributes to therapeutic resistance. MITF is a highly conserved “master melanocyte transcription factor” with a complex role in melanoma. Our lab has previously developed a temperature sensitive BRAFV600E mitfavc7 zebrafish melanoma model carrying a human oncogene and mitfavc7 splice …
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A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
… The melanocyte lineage transcription factor MITF plays a well-defined role in CM tumorigenesis, wherein MITF expression is absolutely necessary for tumorigenesis and regulates proliferative versus invasive tumor phenotypes. In contrast, here we elucidated a novel tumor suppressor function for …
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The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma
… Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are involved in the development of melanoma. To better understand the molecular …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… by IFN-γ, which resulted from the inhibition of MITF expression, upstream molecule of tyrosinase. Moreover, the inhibitory effects on MITF expression by IFN-γ occured through the disturbance of CREB binding ability on MITF promoter by reducing the binding of CBP and CREB. These results suggest …
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A multiplexed approach for quantitative profiling of the translatome using bioorthogonal non-canonical amino acids
… melanoma lineage-dependent transcription factor MITF and MITF targets was observed in MM415s after binimetinib treatment, with no such response in the MelJuso cells. Using a small molecule inhibitor against MITF, we found that MITF inhibitions results in a protective effect against binimetinib in …
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Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
… and Bcl-2, and the transcription factors p53 and MiTF. Although NO favored increased expression and phosphorylation of p53, it also increased the expression of the p53 inhibitor MDM2, which may have counteracted p53-induced apoptosis upon cisplatin treatment. Also, likely via ERK1/2 activation, NO …
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The genetic basis of plumage polymorphism in the black sparrowhawk
… microphthalmia-associated transcription factor (MITF) than the dark morph. The black sparrowhawk also shows distinct rufous juvenile plumage, which is a particularly common trait in raptors. The genetic basis of juvenile plumage was investigated, and eumelanin and pheomelanin levels were found to …
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Pleiotrophin inhibits melanogenesis in normal human melanocyte
… PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes. The inhibitory action of PTN in pigmentation was further confirmed in ex vivo cultured skin and in the melanocytes co-cultured with fibroblasts. These findings suggest that PTN is a crucial …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
… MiT/TFE transcription factors (TFEB, TFE3, and MITF), promoting endolysosomal biogenesis. Furthermore, we showed that STING-induced noncanonical autophagy induces ALIX-meditated ESCRT machinery recruitment to mitigate endolysosomal perturbation. Our study unraveled the multifaceted functions of …
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Not Black and White: BMP Signaling Drives Melanocyte Differentiation Downstream of Stem Cell Activation
… reduced nuclear levels of the master regulator MITF and WNT mediator LEF1. Using WNT mutant mouse models, cell culture systems, and chromatin profiling, I provide evidence demonstrating cooperation of BMP and WNT signaling to trigger complete differentiation of McCP into melanocytes through MITF …
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Wnt Inhibitory Factor (WIF)-1 Promotes Melanogenesis in Normal Human Melanocytes
… tyrosinase activity and increased expression of MITF and tyrosinase. Conclusion: We demonstrated that WIF-1 was expressed in human melanocytes. Our findings suggest that WIF-1 may play a role in melanogenesis.
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Micrornas Associated With Melanoma Inflammation and Response to Pd-1 Inhibition
… specific transcription factors including MITF. Furthermore, investigation of these microRNAs in a cohort of PD-1 inhibitor treated melanoma patients identified a survival benefit in patients whose melanomas had high expression of miR-100-5p and miR-125b-5p. These findings indicate that …
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
… Waardenburg’s (mutations occur in the Pax3 and MITF genes, among others), Pendred's (caused by a mutation in the PDS /pendrin gene) and Usher’s (caused by a mutation in one of several USH genes) Syndromes. In addition, over 70 different genes have been described that produce non-syndromic …
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Wnt Modulators, Secreted Frizzled Related Protein (sFRP) 2 and Wnt Inhibitory Factor (WIF)-1, Stimulate Melanogenesis in Normal Human Melanocytes
… melanocytes through the increased expression of MITF and tyrosinase via β-catenin signaling. Moreover, the epidermal pigmentation of human skin was also increased in the presence of recombinant human sFRP2 and WIF-1. These findings suggest that UV irradiation may stimulate sFRP2 and WIF-1 …
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The SYK tyrosine kinase suppresses autolysosome biogenesis via activation of mTORC1 in pancreatic cancer cell lines
… mediated by the enhanced nuclear localization of MITF, a key transcriptional regulator of genes involved in lysosome biogenesis and autophagy pathway activation. In summary, SYK positively regulates mTORC1 activation in a subset of PDAC cell lines to suppress hyperactivation of autophagy. These …
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Defining cell state regulators in cancers using single-cell analysis and CRISPR-Cas9 screening
… uncovered for multiple targets including SOX10, MITF, EIF3G, PRPF19, RPS27A, and CDC20. Cell line annotations achieved through previous high-throughput screens were also leveraged to uncover associations between the defined heterogeneous expression signatures with features reflecting genetic …
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Evolutionary and Developmental Survey of Genes Involved in Chordate Pigmentation
… of a transcription factors combination (<i>Cr-Mitf, Cr-msxb, Cr-Dmrt</i>). This work contains first data about a Kelch-like member in ascidians, providing new insights in pigmentation or pigment cell specification. This encourages further analyses on its gene regulatory network and possible …
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