Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 470 for “"MHC"”.
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MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) VS NON-MHC INFLUENCES ON RESPONSE TO RSV-INDUCED TUMORS IN CHICKENS
<p>The MHC of the chicken (B complex) has been shown to exert a decisive influence on the fate of Rous sarcoma virus (RSV)-induced tumors. However, noninbred chickens with identical B genotypes and inbred lines indistinguishable at the MHC have demonstrated considerable variation in response to RSV …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived from aberrant expression of non-mutant antigens or driver and passenger somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic …
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MCMV interferiert mit der MHC-Klasse-I-Antigenpräsentation
… beeinflusst die Antigenpräsentation durch MHC-Klasse-I-Moleküle und wird durch das virale Genprodukt von m152 vermittelt. Dieses kodiert für ein Glykoprotein von 40 kDa Größe und wird in dieser Arbeit m152/gp40 genannt. M152/gp40 blockiert den Transport von MHC-Klasse-I-Molekülen zur …
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T-Zell-unabhängige MHC-II-Signaltransduktion durch Superantigene
For a couple of years MHC-II complexes are known for many more assignments than antigen presentation. In this thesis the quite unknown mechanism of superantigen-induced T cell independent MHC-II-signaltransduction is investigated. It could be demonstrated that the superantigen-induced …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T cells can bind to allogeneic MHC given that T cells undergo stringent positive selection during development to …
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VIRAL MODULATION OF MHC CLASS II-MEDIATED ANTIGEN PRESENTATION
… of antigen presentation cells (APC) perturbs MHC class II-mediated antigen (Ag) presentation. The goals of this project include: 1) to define mechanisms by which VV disrupts class II presentation; and 2) to examine whether disruption of the class II pathway by VV alters T cell responses in …
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Nickel-Koordinationsstellen in einem T-Zellrezeptor/Peptid/MHC-Komplex
Nickelallergie, die häufigste Kontaktallergie des Menschen, wird durch Ni-spezifische, HLA-restringierte abT-Zellen verursacht. Die vorliegende Arbeit untersucht im ersten Teil die molekularen Kontakte zwischen T-.Zell Antigenrezeptor (TCR), HLA-Molekül und Ni-Ionen am Beispiel des in einer Maus …
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Structure, Function and Engineering of Peptide -Mhc Binding Receptors
… a T cell receptor interaction with its peptide-MHC ligand was explored using various TCR mutants engineered by yeast display. Previous work in the lab showed that mutations in the CDR3 regions of the TCR could generate higher-affinity, peptide-specific TCR variants. In contrast, other CDRs …
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Defining Mechanisms Contributing to Porcine MHC Class II Diversity
… (DQB: P=0.011 and DRB1: P=0.015) at both MHC loci, between the domestic and Wild boar populations. The European and Asian domestic populations exhibited a higher level of DQB amino acid diversity (0.093 and 0.093, respectively) when compared to the respective Wild boar populations (0.047 …
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Single chain MHC trimer-based DNA vaccines for pathogen protection
… limitations, we have developed fully assembled MHC molecules that can be expressed as membrane-bound proteins on the cell surface, termed single chain trimers: SCTs). SCTs are composed of an immunodominant peptide, β2m, and MHC I heavy chain covalently linked by 15-20 amino acid flexible …
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Characterization of a T Cell Receptor: Peptide/MHC Binding Interaction
… antibodies (mAb), superantigens, and peptide/MHC ligands, we have expressed a family of 2C scTCRs which contain alanine point mutations in the complementarity determining regions (CDR) and fourth hypervariable region of the $\beta$ chain. Using these mutant scTCRs, we have identified V$\beta$ …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… the interest of our laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more specifically, the NKR-P1B:Clr-b receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal …
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Polymerase chain reaction-based genotyping of swine MHC DQB and DRB alleles
"Molecular genotyping the swine major histocompatibility complex DQB and DRB loci using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis technique is described. SLA DQB and DRB locus-specific oligonucleotide primers were designed to analyze expressed genes …
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Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
The Major Histocompatibility Complex (MHC) is a multi-gene family, covering a genomically complex region that plays a pivotal role in immune surveillance and pathogen recognition. Within this region, only a subset of MHC class I (MHC-I) genes encodes classical molecules that present peptides to …
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
Major histocompatibility complex (MHC) class I molecules present fragments of the cellular proteome, in the form of short peptides, to the cell surface for the inspection by cytotoxic T cells. This process is a crucial immunosurveillance mechanism used to induce appropriate immune responses against …
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