Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 457 for “"MHC"”.
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MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) VS NON-MHC INFLUENCES ON RESPONSE TO RSV-INDUCED TUMORS IN CHICKENS
<p>The MHC of the chicken (B complex) has been shown to exert a decisive influence on the fate of Rous sarcoma virus (RSV)-induced tumors. However, noninbred chickens with identical B genotypes and inbred lines indistinguishable at the MHC have demonstrated considerable variation in response to RSV …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived from aberrant expression of non-mutant antigens or driver and passenger somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T cells can bind to allogeneic MHC given that T cells undergo stringent positive selection during development to …
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MCMV interferiert mit der MHC-Klasse-I-Antigenpräsentation
… beeinflusst die Antigenpräsentation durch MHC-Klasse-I-Moleküle und wird durch das virale Genprodukt von m152 vermittelt. Dieses kodiert für ein Glykoprotein von 40 kDa Größe und wird in dieser Arbeit m152/gp40 genannt. M152/gp40 blockiert den Transport von MHC-Klasse-I-Molekülen zur …
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VIRAL MODULATION OF MHC CLASS II-MEDIATED ANTIGEN PRESENTATION
… of antigen presentation cells (APC) perturbs MHC class II-mediated antigen (Ag) presentation. The goals of this project include: 1) to define mechanisms by which VV disrupts class II presentation; and 2) to examine whether disruption of the class II pathway by VV alters T cell responses in …
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Nickel-Koordinationsstellen in einem T-Zellrezeptor/Peptid/MHC-Komplex
Nickelallergie, die häufigste Kontaktallergie des Menschen, wird durch Ni-spezifische, HLA-restringierte abT-Zellen verursacht. Die vorliegende Arbeit untersucht im ersten Teil die molekularen Kontakte zwischen T-.Zell Antigenrezeptor (TCR), HLA-Molekül und Ni-Ionen am Beispiel des in einer Maus …
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Structure, Function and Engineering of Peptide -Mhc Binding Receptors
… a T cell receptor interaction with its peptide-MHC ligand was explored using various TCR mutants engineered by yeast display. Previous work in the lab showed that mutations in the CDR3 regions of the TCR could generate higher-affinity, peptide-specific TCR variants. In contrast, other CDRs …
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Defining Mechanisms Contributing to Porcine MHC Class II Diversity
… (DQB: P=0.011 and DRB1: P=0.015) at both MHC loci, between the domestic and Wild boar populations. The European and Asian domestic populations exhibited a higher level of DQB amino acid diversity (0.093 and 0.093, respectively) when compared to the respective Wild boar populations (0.047 …
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Single chain MHC trimer-based DNA vaccines for pathogen protection
… limitations, we have developed fully assembled MHC molecules that can be expressed as membrane-bound proteins on the cell surface, termed single chain trimers: SCTs). SCTs are composed of an immunodominant peptide, β2m, and MHC I heavy chain covalently linked by 15-20 amino acid flexible …
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Characterization of a T Cell Receptor: Peptide/MHC Binding Interaction
… antibodies (mAb), superantigens, and peptide/MHC ligands, we have expressed a family of 2C scTCRs which contain alanine point mutations in the complementarity determining regions (CDR) and fourth hypervariable region of the $\beta$ chain. Using these mutant scTCRs, we have identified V$\beta$ …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… the interest of our laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more specifically, the NKR-P1B:Clr-b receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal …
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Polymerase chain reaction-based genotyping of swine MHC DQB and DRB alleles
"Molecular genotyping the swine major histocompatibility complex DQB and DRB loci using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis technique is described. SLA DQB and DRB locus-specific oligonucleotide primers were designed to analyze expressed genes …
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Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
The Major Histocompatibility Complex (MHC) is a multi-gene family, covering a genomically complex region that plays a pivotal role in immune surveillance and pathogen recognition. Within this region, only a subset of MHC class I (MHC-I) genes encodes classical molecules that present peptides to …
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
Major histocompatibility complex (MHC) class I molecules present fragments of the cellular proteome, in the form of short peptides, to the cell surface for the inspection by cytotoxic T cells. This process is a crucial immunosurveillance mechanism used to induce appropriate immune responses against …
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Associations between MHC class I variation and blood pathogen prevalence in caracal
… Genes of the Major Histocompatibility Complex (MHC) trigger the vertebrate adaptive immune response to pathogens through the recognition and presentation of foreign peptides, and thus provide an informative genetic marker for studying the adaptive potential of species with respect to disease. …
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A biochemical study of Class II MHC and cytochrome P-450scc proteins
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1999.
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Understanding the effects of higher order sequence features on peptide MHC binding
… the factors that contribute to peptide-MHC (pMHC) affinity is critical for the study of immune responses and the development of novel therapeutics. In this thesis we propose the use of sequence feature representations as a means of capturing and categorizing these factors, and we develop …
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