Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"MEP"”.
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Einfluß von Medikamenten und Narkotika auf motorisch evozierte Potentiale nach transcranieller Cortexstimulation
… Auswertung von motorisch evozierten Potentialen (MEP) nach elektrischer und magnetischer transcranieller Stimulation des motorischen Cortex. Der Einfluß verschiedener Stimulations- und Untersuchungsbedingungen wird an 3320 motorischen Muskelantworten von 41 Probanden untersucht. Erst-mals wird die …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… subchronic moderate ethanol preconditioning (MEP, 20-30mM for ~6d) protects organotypic brain slice cultures from amyloid-beta (Aβ), the neurotoxic peptide most often associated with AD. It is possible that the mechanism of MEP neuroprotection from Aβ toxicity may further our understanding of …
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DNA Triplexes in chemistry biology and medicine
… -3-methyl-5-(2’-deoxy-?-D-ribofuranosyl)pyridine (MeP). The phosphoramidite monomer of MeP was synthesised and incorporated as a “protonated” cytidine analogue into triplex forming oligonucleotides (TFOs). It was compared with other cytosine analogues, 5-methyl-(2’-deoxy-?-D-ribofuranosyl)cytosine …
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Regulatory and Economic Consequences of Empirical Uncertainty for Urban Stormwater Management
… systems to the "maximum extent practicable" (MEP), using a combination of structural and non-structural stormwater treatment — known as stormwater control measures (SCMs). The MEP regulatory paradigm acknowledges that there is empirical uncertainty regarding SCM pollutant reduction capacity, …
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The Value of Human Resource Development to an Organization; Providing Technical Assistance to Small Manufacturing Companies
… the Manufacturing Extension Partnership (MEP) program to create and implement a nationwide system of technical assistance centers, staffed by knowledgeable manufacturing and other business system professionals, to enable small and medium-sized manufacturers reach this goal. Each of the 78 …
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The Immediate Effects of Electromyographic Biofeedback on Corticomotor Excitability of the Quadriceps in Healthy Individuals
… to elicit a motor evoked potential (MEP) of =100µV amplitude in at least 5 of 10 trials. Five MEPs were collected at AMT. The participants then performed a MVIC of the quadriceps. When maximal effort plateaued a stimulus was given and the MEP peak-to-peak amplitude was recorded for …
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Hearing Function in Obstructive Sleep Apnoea (OSA) patients and its impact with Continuous Positive Airway Pressure (CPAP)
… ear disorder. During sleep, middle ear pressure (MEP) increased in all patients, regardless of OSA severities. The increase in MEP was not associated with oxygen saturation. Cochlear hair cell function and hearing thresholds were not impacted after sleep in patients with OSA. CPAP treatment …
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L’effet de la neurostimulation périphérique sur la douleur induite par l’exercice chez les femmes vivants avec la fibromyalgie
… widespread pain and movement-evoked pain (MEP). While resistance training benefits fibromyalgia patients, early pain flare-ups (i.e. MEP) can hinder adherence. Transcutaneous electrical nerve stimulation (TENS) is a safe, non-pharmacological technic that provides pain relief, but its …
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The design and synthesis of novel potential antimalarial compounds
… novel approaches towards non-mevalonate pathway (MEP) intermediates and inhibitors. The synthesis towards a previously unpublished 2,2-dimethyl MEP analogue, is described alongside the attempted generation MEP. The methodology described herein shows the use of Neighbouring Group Participation in …
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An energy optimal power supply for digital circuits
… at their minimum energy operating voltage (MEP) has been proposed as a solution for energy critical applications where performance is not a key constraint. This thesis explores the sensitivity of the MEP to operating conditions and motivates the need for continuous minimum energy tracking …
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MMV008138 and analogs: potential novel antimalarial agents for P. falciparum
… pathway: the methylerythritol phosphate (MEP) pathway. This pathway is not utilized by humans. Thus, compounds that target the MEP pathway and disrupt isoprenoid biosynthesis in P. falciparum hold promise as potent and safe new antimalarial agents, that engage new targets. Previously, we …
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Structural, functional and mechanistic analysis of the Escherichia coli ammonium transporter AmtB
… transporter/Methylammonium permease/Rhesus (Amt/Mep/Rh) superfamily of membrane proteins. Inaddition to their fundamental role in facilitating the transport of metabolites, members of the Amt/Mep/Rh superfamily are important drivers of the virulence of infectious fungi. In humans, malfunctions of …
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Engineering Drawing Segmentation and Understanding For Building Construction Digital Twins
… essential mechanical, electrical, plumbing (MEP) components and structural components. Converting these drawings into BIM models remains a largely manual process, which is time-consuming, difficult to scale, and costly. This thesis presents a computer vision–based pipeline designed to …
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Molecular target identification of antimalarial drugs using proteomic and metabolomic approaches
… through the methylerythritol phosphate (MEP) pathway in the malaria parasite while humans utilize the mevalonate pathway. Therefore, the MEP pathway is a source of drug targets for drug development. Our group has identified MMV008138 as anti-apicoplast inhibitor through phenotypic …
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
… inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and inhibition of isoprenoid synthases in human cancers. For the development of antibacterials and antiparasitics, this research investigates the structure, function, …
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Series expansion of the Modified Einstein Procedure
… based on the Modified Einstein Procedure (MEP). A new procedure based on the Series Expansion of the Modified Einstein Procedure (SEMEP) has been developed. This procedure contains four main modifications to MEP. First, SEMEP solves the Einstein integrals quickly and accurately based on a …
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Central nervous system organisation following traumatic incomplete spinal cord injury (iSCI) : a longitudinal clinical study
… amplitude and latency. Motor Evoked Potentials (MEP) parameters are a reliable electrophysiological measure of motor function, and are used in concordance with the clinical Asia Impairment Scale scores. MEP parameters have a potential relevance to functional outcomes such as hand function and …
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Studying magnetic and 3D atomic structure using 4D scanning transmission electron microscopy
… resolution in multislice electron ptychography (MEP), a computational technique that, given a 4D-STEM dataset, creates a 3D reconstruction of a sample. MEP has been shown to have excellent in-plane resolution of as high as 0.2 angstroms, while depth resolution is limited to 2-4 nm. However, we …
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