Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 424 for “"M1"”.
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FRET-Based Conformational Sensor for the m1 Muscarinic Cholinergic Receptor
… an optical conformational sensor for the m1 muscarinic cholinergic receptor (M1), a prototypical G protein-coupled receptor (GPCR), to study how receptor activity is regulated by the coordinated action of agonist, G protein and GAP. To create the sensor, I adopted an underlying design …
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
… lesions and their progression. The presence of M1 and M2 macrophages in human atherosclerotic lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human macrophages in different inflammatory diseases including atherosclerosis. These …
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NMR-Based Characterization of Proteins: Structure, Dynamics and Binding Interfaces of Influenza A's M1
… domain of Influenza A Matrix Protein 1 (M1), detailing its structure, dynamic behavior, and potential interfaces involved in molecular recognition and binding. Chapter 4 investigates these interfaces further, in the context of mechanistic self-assembly, nucleic acid association, and …
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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all prescribed drugs. Cells …
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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all prescribed drugs. Cells …
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Predicting nominal GNP and testing the variability of the domestic money stock against M1
A proposal was made by Albert Burger and Anatol Balbach to measure the money stock by excluding foreign holdings of U. S. dollars. This measure termed "domestic money stock" was tested against Ml to observe which was the least variable and which would predict GNP with the least error. The test were …
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Provenance, geochronology and sedimentary characteristics of the Campanian M1 Sandstone, Napo Formation, Oriente Basin, Ecuador
The Campanian-Maastrichtian M1 Sandstone is one of the major oil reservoir units of the Napo Formation in the Oriente Basin of Ecuador. Heterogeneous reservoir behavior suggests that the depositional environments of the M1 Sandstone were laterally variable, such that they generated complex …
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Η ΧΡΗΣΗ ΤΟΥ GELASTYPT M1/2 ΣΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΕΥΜΕΓΕΘΩΝ ΚΥΣΤΕΩΝ ΤΩΝ ΓΝΑΘΩΝ. ΠΕΙΡΑΜΑΤΙΚΗ ΚΑΙ ΚΛΙΝΙΚΗ ΜΕΛΕΤΗ
… -UP WITH THE ALLOPLASTIC MATERIAL GELASTYPT-M1/2 AND THOSE THAT HAS NOTHING FOREIGN INSIDE. IN OUR EXPERIMENT WE USED 10 DOGS AND IN OUR CLINICAL WORK20 PATIENTS. A SIGNIFICANT DEGREE OF DECREASED HEALING OF THE BONE IN THE CASES WITH GELASTYPT M1/2 WAS SEEN, IN OUR DOGS. CLINICAL WAS FOUND …
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Synthesis and Investigation of Phase-pure M1 MoVTeNbOx Catalysts for Selective Oxidation of Propane to Acrylic Acid
… orthorhombische, bronzeartige Phase, die als M1 bezeichnet wird und die mit der hohen Aktivität und Selektivität von MoVTeNb-oxid Katalysatoren in der direkten Oxidation von Propan zu Acrylsäure in Verbindung gebracht wird. Andere Phasen, die gebildet werden, sind z. B. die orthorombische M2 …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… identification and characterization of the VACV M1 protein as a caspase inhibitor and (ii) investigating a previously unexplored method to alter the immunogenicity of the attenuated VACV MVA. One anti-viral host response inhibited by VACV during infection is apoptosis. The attenuated MVA strain …
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REGENERATION OF ELECTROSPUN BIORESORBABLE VASCULAR GRAFTS: A PHENOMENON ASSOCIATED WITH VASCULAR GRAFT PROPERTIES AND MACROPHAGE PHENOTYPES (M1/M2)
… plasticity and can acquire pro-inflammatory (M1) or angiogenic/wound healing (M2) phenotypes depending upon the environmental stimuli. The phenotypic profile of MФ as M1 or M2 following exposure to the biomaterial can dictate the downstream processes of tissue remodeling and angiogenesis. An …
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Mirror Neurons are Modulated by Reward Expectation and Grip Force in the Sensorimotor Cortices (S1, M1, PMd, PMv)
… indicates that reward expectation influences M1 during manual, observational, and Brain Machine Interface (BMI) reaching movements. Previous work showed MN are modulated by subjective value. Here we expand on the above work utilizing two non-human primates (NHPs), one male Macaca Radiata (NHP …
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Separation of the E2 and M1 form factors of the 6.32 MeV state of nitrogen-15 using (electron,electron'gamma)
… two transverse multipole form factors (E2 and M1) were separated using a combined analysis of (e,e$\sp\prime$) and (e,e$\sp\prime\gamma$) data. This experiment is the first model independent separation of the multipoles that contribute to a mixed transition. Data were obtained with the MAMI A …
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Investigation of preferential binding properties of monoclonal antibodies M1:1D2 and H4:4 towards the conformers of recombinant prion protein
… in body fluids. In this project the two mAbs M1:1D2 (IgG3) and H4:4 (IgG2a) which were raised against prion protein purified from outdated human platelets were tested for their specificity against SDS aggregated recombinant human PrP peptide. The mAbs were able to discriminate between …
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Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma
… and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to different levels of OGD using a custom-built chamber to control oxygen levels. Cell survival was …
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Determining the optimal paradigm for investigating if M1 activations associated with step tracking wrist movements are direction or muscle related using EEG
… detected within the primary motor cortex (M1) during a wrist step tracking task encoded movement direction or specific muscle groups used to achieve the movement. This will provide information on the processes which occur within M1 of the human brain. Experiments were designed to examine in …
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Charakterisierung von Monozyten anhand ihrer Interleukin-10-Produktion und Darstellund der Existenz funktionell unterschiedlicher Subpopulationen (M1/M2) analog den Th1/Th2-Schema
… Monozyten-Subpopulationen existieren, die als M1-Monozyten (entsprechend klassisch aktivierten Makrophagen) und M2-Monozyten (entsprechend alternativ aktivierten Makrophagen) bezeichnet werden können.
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LPS from subgingival plaque and the periodontal pathogen Porphyromonas gingivalis, its effect on M1 and M2 macrophage responses and potential as a biomarker
… of TNF-α and Th17 associated IL-23 compared to M1 MΦs. Proteomic and subsequent gene ontology analysis indicated opposing mechanisms of activation in MΦ subsets. The unfolded protein response was identified to be induced in M1 MΦs challenged with PG LPS combined with an increased susceptibility …
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