Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"Lung tissue"”.
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In Vitro Development of Engineered Lung Tissue
<p>Lung disease is the third most common cause of death in the United States, resulting in 400,000 deaths annually \cite{ALA:08}. For many diseases, lung transplantation is the only definitive treatment, yet only 2700 lung transplants are performed each year, limited primarily by a lack of donor …
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Expression of antimicrobial peptides in human lung tissue
Lunga mannsins er mjög flókið líffæri sem er samansett af pípulaga líffærakerfi sem tengist andrúmsloftinu í gegnum öndunarveginn. Í lunganu eiga sér stað loftskipti á súrefni og koltvíoxíði og þarf lungað því að hafa vel skipulagt ónæmiskerfi. Þegar lofti er andað inn í lungun fylgja mikið magn af …
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Exploring Tissue Microstructure in Healthy and Diseased Lung Tissue
… part examines diffusion in a number of human lung samples, while the second deals with diffusion in the more simplified environment of a single capillary tube. In the lung study we examine various types of lung samples: healthy and diseased) at a variety of diffusion lengths. Diffusion …
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Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix
… this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and …
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The role of accelerated ageing in aberrant lung tissue repair and remodelling in COPD
… with characteristic of ageing demonstrated in lungs from COPD patients compared to age-matched smokers without COPD. Recently, extracellular matrix (ECM) dysregulation has been described as an additional ageing hallmark of the lungs. ECM dysregulation can cause aberrant lung tissue repair and …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
<p>Radiation-induced lung injury (RILI) is caused by an early inflammatory process triggered by damage to lung parenchyma, epithelial cells, vascular endothelial cells and stroma. Initially, oxidative injuries after radiation induce altered expression of pro-inflammatory cytokines. Infiltrating …
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Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice
… types of cancer, including cancers of the lung and bladder. Carcinogens in the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a carcinogenic chemical and DNA. An increase in the number of DNA adducts …
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Design, production and evaluation of an auxetic straining device for application in lung tissue engineering scaffolds
One of the main challenges in lung tissue engineering is the replication of the complex structure and mechanics of the native environment. This thesis addresses two main objectives: firstly, the development of biomimetic scaffolds, based on collagen type I, that replicate the porous architecture of …
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An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue
… modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 72 lung biopsy samples acquired from patients. This compared with 10% in healthy controls. Little is known of immune mechanisms acting on T. gondii infected lung …
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An investigation into the direct and indirect effects induced by platelet-activating factor receptor activation in rat isolated lung tissue.
… platelet-activating factor (PAF) on rat isolated lung strips and tracheal spirals. Previous studies have shown that PAF induces hyperresponsiveness to the contractile effects of acetyicholine (ACh) and 5- hydroxytryptamine (5-HT) in rat isolated tracheal spirals. In this study it was hoped that …
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Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
… and fibrotic events in the small airways and lung parenchyma; including fibrosis, emphysema and mucus plugging. This work focuses on the inflammatory and fibrotic aspects of COPD pathology. Processes of fibrotic Epithelial to Mesenchymal Transition (EMT) have been identified in heart and …
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Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia
VAP is described as a pneumonic lung infection afflicting those that have been mechanically ventilated typically with an endotracheal tube. Unfortunately, there is no singular diagnostic test for VAP (Grossman & Fein, 2000) or ‘gold standard’ for the identification and diagnosis of the disease …
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Studies on the fungal microflora of the environment of the allergic patient
… nasal swabs, sputum, bronchoscopy specimens and lung tissue. The dominant fungi isolated were Penicillim spp. and Aspergillus spp. A size effect was demonstrated in the sistribution of spores. Lung tissue from patients suffering with respiratory disease contained many fungi, whereas the lungs of …
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The dissolution rate of chrysotile
Chrysotile can be linked to three diseases: lung cancer, asbestosis, and mesothelioma. The duration and intensity of exposure along with fiber size appear to play an important role in the development of the diseases. Chrysotile is part of the serpentine group which has the general composition of …
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Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy
… epoxide (BPDE) in human lung tissue and human bronchial epithelial cell histones and DNA and in human serum albumin. The presence of BPDE adducts in human lung tissue and human bronchial epithelial cell histones and DNA was proven by cryogenic fluorescence line-narrowing …
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Development of a Lung Surrogate Model for Assessing Biomechanical Responses to Underwater Explosions (UNDEX)
… to investigate the biomechanical response of lung tissue during UNDEX events. A representative lung surrogate was designed to mimic the mechanical behavior of human lungs, utilizing thermoplastic elastomers (TPE) and polyurethane foam to replicate the elastic and porous nature of lung tissue …
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Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
… whether an inflammatory pathology is apparent in lung tissue in older, KO mice that are at high-risk for SUDEP and wildtype (WT) control littermates treated with either control diet or ketogenic diet (KD). Data indicates respiratory pathology in KO mice. Increased expression of MyD88, NF-kB p65, …
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Glucocorticoid resistance in COPD patients and lung cancer
… mainly in the small airways and in parenchymal tissue. Inflammatory mediators, such as cytokines, chemokines and oxygen free radicals, orchestrate the inflammatory response, causing disruption of the epithelial surface and the surrounding microenvironment in the lung tissue. Glucocorticoids are …
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Exploring Immersed FEM, Material Design, and Biological Tissue Material Modeling
… the modeling and parameterization of lung tissue for Diver Underwater Explosion (UNDEX) simulations. In the first part, a shape optimization scheme utilizing a four-noded rectangular immersed-interface element is presented. This method eliminates the need for interface fitted mesh or …
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