Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Leishmaniasis"”.
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Arsenic, antimony and visceral leishmaniasis
… compounds in the treatment of visceral leishmaniasis (VL) has declined from over 85% to less than 50%. This has been attributed to prolonged, widespread misuse of antimonials within the Indian private healthcare system. An alternative resistance hypothesis is that exposure to arsenic in …
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Antibody Dependent Enhancement of Visceral Leishmaniasis
Leishmaniasis is a parasitic disease caused by protozoans of the genus <em>Leishmania</em>. This vector-born disease, transmitted by biting phlebotomine sandflies, typically manifests in one of three ways. The cutaneous form of the disease is characterized by localized lesions of the skin and is by …
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New therapeutic strategies against trypanosomiasis and leishmaniasis
Leishmaniasis and African Trypanosomiasis are diseases caused by the Kinetoplastida parasites of Leishmania sp. and Trypanosoma sp. respectively. Control and management of these diseases, which affect a significant number of people in the tropics and subtropical areas of the world, is beset with …
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Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
Leishmaniasis is a neglected tropical disease responsible for considerable morbidity and mortality in the developing world. The immune response against Leishmania parasites must be fine-tuned to promote pathogen clearance without triggering excess inflammation, and this requires the concerted …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
Visceral leishmaniasis, caused by infection with the intracellular protozoan Leishmania donovani, is a chronic disease that affects the spleen, liver and bone marrow. Patients present with high parasite burdens in visceral organs, splenomegaly, cachexia, pancytopenia and will progress to death if …
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Evaluación del desempeño diagnóstico de pruebas rápidas para Leishmaniasis Visceral
La Leishmaniasis Visceral (LV) es la forma mortal de las Leishmaniasis, la cual causa la muerte a más del 90% de los pacientes que la padecen. El diagnóstico de la LV se realiza a través de la observación directa del parásito lo que requiere procedimientos complejos restringiendo su uso a centros …
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Investigation of a new focus of Cutaneous Leishmaniasis in Ghana
Leishmaniasis is a disease of significant public health importance, which burdens a number of countries around the world, particularly in the tropics and subtropics. An outbreak of suspected cutaneous leishmaniasis (CL) has been witnessed in the Ho district of the Volta region in the south-eastern …
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Immunopathogenic mechanisms of non-healing cutaneous leishmaniasis caused by Leishmania amazonensis infection
… face in the control of non-healing cutaneous leishmaniasis.
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Analysis and robust simulation of mathematical models of HIV and Leishmaniasis co-infection
… study of epidemiological models of Visceral Leishmaniasis (VL) and human immunode ciency virus (HIV) coinfection. We study these models theoretically and design and analyze robust numerical methods to solve them. The rst sub-model describes the transmission dynamics of VL and incorporates …
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Solution and solid-phase synthesis of potential carbohydrate vaccines for leishmaniasis and malaria
The human disease leishmaniasis afflicts over 20 million people worldwide, and is caused by unicellular protozoan parasites. Cell surface carbohydrates are implicated in immune recognition of the parasite by host macrophages. The synthesis of a unique tetrasaccharide found on the parasite cell …
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Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
Protozoan Leishmania is an important human pathogen that affects millions people worldwide. Investigation of experimental Leishmania infection in mice has been instrumental to our understanding of interactions between the parasite and the host immune system. Previous studies have established the …
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Cutaneous Leishmaniasis, (oriental sore) in Nasiriyeh (Euphrates L. of C.) during the years 1916-1920
1. At Nasiriyeh, all the available evidence points to the SAND FLY, probably PHEBOTOMUS MINUTUS, as the transmitting agent of ORIENTAL SORE. 2. O the various methods of treatment employed, the INTRAVENOUS INJECTIONS OF TARTAR EMETIC seems the best for bases of multiple sores and CURETTING in cases …
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Repurposing quinoline-based (metallo) drug leads for the treatment of Leishmania major-induced cutaneous leishmaniasis
Leishmaniasis is a vector-borne neglected tropical disease, of which cutaneous leishmaniasis is the most common form. There is a crucial need to develop new drugs for cutaneous leishmaniasis, as current drugs are sub-optimal due to parasite-specific drug resistance, drug-induced host toxicity and …
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Non-ionic surfactant vesicles as an Amphotericin B inhaled delivery system for the treatment of leishmaniasis
… B (AmB) is a drug used to treat visceral leishmaniasis and fungal infections. Current available AmB formulations are limited by instability at tropical temperature, parenteral administration, renal toxicity (Fungizone®) or cost (AmBisome®, Amphotec® and Abelcet®). In this study, inhaled …
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AN ANALYSIS OF CUTANEOUS LEISHMANIASIS (CL) IN ALDAWADMI GOVERNORATE, SAUDI ARABIA USING GEOGRAPHICAL INFORMATION SYSTEM (GIS)
Leishmaniasis has been described by the World Health Organisation as a ‘neglected disease’ and not well understood, which reflects the variations in transmission cycle, reservoirs, vectors, clinical manifestations, and its associations with many human factors. One country where Cutaneous …
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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… responses. During L. major-induced cutaneous leishmaniasis, Treg cells accumulation at the site of infection has been implicated in suppressing a detrimental Type 2 immune response by modulating early interleukin (IL)-4 production, however it remains unclear if IL- 4Rα mediated signalling on …
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The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.
… in the human host causes severe cutaneous Leishmaniasis. The study aims to determine how signaling via the IL-4Rα on CD4+T cells causes susceptibility to L. major. We compared gene expression patterns early during infection in CD4+ T cells in the absence or presence of IL-4Rα signaling. …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
Leishmaniasis is a vector-borne neglected tropical disease caused by Leishmania parasites. Approximately one million Leishmania infections are reported annually with one billion people residing in 98 countries at risk of infection. Cutaneous leishmaniasis (CL), characterized by skin lesions caused …
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Dendritic cells activated by CpG motifs are potent inducers of a Th1 immune response that protects mice against leishmaniasis
… cells (DC) that protects mice against fatal leishmaniasis. DC were generated from bone marrow precursors, pulsed with leishmanial antigen and activated with CpG oligodeoxinucleotides. Mice that were vaccinated with these cells were strongly protected against the clinical and parasitological …
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