Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Lanthipeptide"”.
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Mechanistic studies of lanthipeptide biosynthesis
… symptoms, novel natural products are demanded. Lanthipeptides are ribosomal peptides with post-translationally incorporated thioether crosslinks named lanthionine. This family of natural products has garnered substantial attention during the past few decades due to their favorable biological …
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Stereochemical control in lanthipeptide biosynthesis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Development of lanthipeptide engineering strategies
… important source of therapeutic compounds. The lanthipeptides, members of the ribosomally synthesized and post-translationally modified peptide class of natural products, have potential applications ranging from clinical imaging to cystic fibrosis treatment. Additionally, many lanthipeptides …
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Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides
Lanthipeptides are natural products that belong to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs). They contain the characteristic lanthionine (Lan) or methyllanthionine (MeLan) structures that contribute to their diverse biological activities. ProcM is a …
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Investigation of class v lanthipeptide biosynthetic pathway
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Biosynthesis and engineering of lanthipeptide natural products for novel applications
… focus on the biosynthesis and engineering of lanthipeptide natural products, a large group of polycyclic RiPPs classified by their intramolecular thioether crosslinks, for expanded functionalities. Protein-protein interactions (PPI) have been involved in many important biological and …
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Mechanistic studies of lanthipeptide biosynthetic enzymes and discovery of novel lanthipeptides
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Application of a substrate-tolerant lanthipeptide synthetase in bioengineering peptide natural products
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Discovery and characterization of RiPP natural products from radical SAM and lanthipeptide hybrid biosynthetic gene clusters
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Structural and mechanistic studies of class III lanthipeptide biosynthesis, an α-N methyltransferase, and a sabath yerba mate methyltransferase
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… of RiPPs is the lanthionine-containing peptides (lanthipeptides), which are characterized by intramolecular thioether crosslinks dubbed lanthionine (Lan) and methyllanthionine (MeLan). The evolvability and brevity of lanthipeptide biosynthetic pathways as well as the substrate tolerance of the …
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The biosynthesis and discovery of lanthipeptides
… structural diversity and potential applications. Lanthipeptides are one class of natural products that have provided antibiotics to the food industry and drug candidates for treating human diseases. Lanthipeptides are polypeptides enzymatically decorated with lanthionine rings and sometimes other …
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Discovery and structural characterization of lanthipeptides from soil and rumen bacteria
… modified peptide natural products (RiPPs), lanthipeptides possess myriad structural diversity and potential for discovery using genome-guided approaches. Biological activities of interest embedded within lanthipeptide structures include antimicrobial, antiviral, and morphogenetic functions. …
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… Research in the van der Donk lab focuses on lanthipeptides, a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that commonly feature antibacterial activity and contain the characteristic thioether residues lanthionine (Lan) and methyllanthionine (MeLan). …
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Ecology and evolution of lanthipeptides in marine picocyanobacteria
… and functionally complex molecules in nature. Lanthipeptides are ribosomally derived peptide secondary metabolites that undergo extensive post-translational modification. Most lanthipeptides are bactericidal but they are also known to act as signaling molecules or morphogenetic peptides, …
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Investigation and application of substrate tolerant thioether forming enzymes
… thioether containing natural products. Lanthipeptides contain thioether rings and have demonstrated diverse biological activities. This group of natural products are of great interest due to their diverse ring topology and high substrate tolerance of the biosynthetic enzymes. Amongst …
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Total Synthesis of Naturally Occurring Antimicrobial Peptides
… the first total synthesis of naturally occurring lanthipeptide tikitericin, as well as its N-terminal truncated analogues. The thesis also explores the total chemical synthesis of the lipopeptide antibiotic daptomycin and analogues along with evaluation of their antibacterial activity. Tikitericin …
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Biosynthesis and engineering of lanthipeptides
… post-translational modified peptides (RiPPs). Lanthipeptides are a class of RiPPs with pharmaceutically valuable properties including antimicrobial activity against clinically-relevant bacterial pathogens, even including drug-resistant strains. These peptides are characterized by thioether …
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Investigating the Mechanisms of the Biosynthesis of Lexapeptide
… use. One class of useful antimicrobials are the Lanthipeptides. Lanthipeptides are characterised by the presence of lanthionine macrocycles and α,β-unsaturated amino acids such as 2,3-dehydroalanine (Dha) and (Z)-2,3-dehydrobutyrine (Dhb). Currently, the only lanthipeptide that has been approved …
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Chemical and chemoenzymatic syntheses of lantibiotics and other bioactive cyclic peptides
… One emerging family of natural products, the lanthipeptides, is defined by the presence of the thioether-containing crosslinks lanthionine and methyllanthionine and includes many members with promising activities against clinically-relevant bacterial pathogens, including drug-resistant …
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