Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Lab on chip"”.
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Manufacturability of lab-on-chip devices : dimensional variation analysis of electrode foils using visual technology
Electrodes are necessary components for measuring changes in electrical properties in many microfluidic devices. Daktari CD4 Cell Counter system utilizes an interdigitated electrode foil in order to measure the concentration of the CD4 cells in an assay chamber by measuring the impedance drop. Thus …
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Integration of photonic and passive microfluidic devices into lab-on-chip with femtosecond laser materials processing
Femtosecond laser materials processing is a powerful method for the integration of high resolution, 3D structures into Lab-On-Chip (LOC) systems. One major application of femtosecond laser materials processing is waveguide fabrication in glass via index modification. We demonstrate the ability to …
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Manufacturability of lab on chip devices : reagent-filled reservoirs bonding process and its effect on reagents flow pattern
In its lab-on-a-chip product, Daktari Diagnostics utilizes "reagent-filled reservoirs" as a means of storing and delivering the liquid reagent. During the clinical trials of the product, undesired reagent flow patterns (namely, flow anomaly 1 & flow anomaly 2) were noticed. This work focused on …
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Biochemical sensing using Siloxane polymer waveguides
… sensing. Recent advances in the integration of polymeric optical waveguides with electronics onto standard printed circuit boards (PCBs) allow the formation of cost-effective lab-on-achip modules suitable for mass production. This technology has been primarily designed for on-board data …
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Microbead-Based Biosensing in Microfluidic Devices
… acids, from a biological sample. The integration of microbeads into microfluidic systems for biological testing is an area of growing interest. Such "lab-on-chip" systems are designed to integrate several functions of a conventional laboratory onto a single chip. As a platform to capture …
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FABRICATION OF POLYMER NANOFLUIDIC CHIPS WITH PROTON BEAM WRITING AND NANOIMPRINTING FOR DNA LINEARIZATION
Nanofluidic enclosed lab on chip (LOC) devices with nano size patterns and fast fabrication capability are required for biomedical experiments. Nanopatterning and fabrication methods for nanochannel devices are discussed with focusing on proton beam lithography, Ormostamp mold casting, …
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A General Purpose Programmable Microfluidic Platform for Screening and Optimization of Biological Assays
… an otherwise unmanageable task with manual labor. However, these systems are capital intensive which limit their use to large pharmaceutical companies or larger research labs. Additionally, reagent consumption is of the order of 10-100 µL per assay, which leads to substantial consumables …
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A universal miniaturized electrochemical sensing platform and its applications
… platform, which integrates with a microelectronic sensor strip, that can perform various electrochemical and impedance sensing measurements. This sensing platform works as a miniaturized potentiostat that supports a number of potential waveforms such as cyclic voltammetry (CV) and differential …
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Single molecule analysis of DNA electrophoresis in microdevices
… large O[100 kilobasepair] DNA, several promising lab-on-chip designs for DNA mapping have been recently proposed that require either 1) a DNA molecule negotiating an obstacle course in a microchannel or 2) stretching a DNA molecule for linear analysis. The goal of this research is to …
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Simulation and Characterization of Single Photon Detectors for Fluorescence Lifetime Spectroscopy and Gamma-ray Applications
… Spectroscopies are driving the development of non-imaging silicon photon sensors and, in this context, Silicon Photo-Multipliers (SiPM)s are leading the starring role. They are 2D array of optical diodes called Single Photon Avalanche Diodes (SPAD)s, and are normally fabricated with a dedicated …
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A comprehensive study and validation of high-throughput microscale electrode production using thermal transfer printing techniques
Adoption of Lab-on-Chip technology, which combines microfluidics with laboratory processes, is steadily increasing within the global health diagnostics field. An important element of this technology is the sensing and measurement capabilities of associated microelectronics. This thesis presents a …
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Technology and market evaluation for semiconductor nanowire transistors
Information processing systems have been getting more powerful over the course of the past three decades due to the scaling of transistor dimensions. Scaling of transistor dimension causes a plethora of technological problems if pursued in the current fashion. Gate-All-Around architecture for …
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Microfluidic bubble logic
… transport and manipulate materials and information. Information representation is invariably physical. Though this insight is fundamental to understanding the physical limits of computation, it has never been exploited as a scheme for material manipulation. Bringing together notions from computer …
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Modeling and Fundamental Design Considerations for Portable, Wearable and Implantable Electronic Biosensors
Chronic diseases such as cancer, diabetes, acquired immune deficiency syndrome (AIDS), etc. are leading causes of mortality all over the world. Portable, wearable and implantable biosensors can go a long way in preventing these premature deaths by frequent or continuous self-monitoring of vital …
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Investigation of fluids flow behavior in nano-scale channels by using optic imaging system
… channels is of major importance for stimulation design, gas production optimization and calculations of the relative permeability of gas in tight shale gas systems. In this work, a lab-on-chip approach for direct visualization of the fluid flow behavior in nano-scale channels was developed …
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Nanotechnology and neuroscience: innovative advances and limitations in the diagnosis and treatment of sacral chordoma
… οδηγήσει σε εξελιγμένα νανοσωματίδια, συστήματα lab-on-chip και εξατομικευμένες μεθόδους χορήγησης φαρμάκων, με αποτελέσματα πιο ακριβή και λιγότερο επιβλαβή για τον οργανισμό. Αυτές οι εξελίξεις είναι ιδιαίτερα σημαντικές στη νευροχειρουργική και ογκολογία, για τη διαχείριση σπάνιων και …
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Magnetic domain walls for on-chip transport and detection of superparamagnetic beads
Surface-functionalized superparamagnetic (SPM) microbeads are of great interest in biomedical research and diagnostic device engineering for tagging, manipulating, and detecting chemical and biological species in a fluid environment. At the same time, lab-onchip technologies have grown popular due …
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CMOS nanofluidics
… diagnostics is a market worth US$ 40-45 billion. Diagnostic tests are usually conducted in centralized laboratories, equipped with expensive instrumentation and staffed with trained personnel. An important part of clinical diagnosis involves protein and DNA sensing. Significant effort is made …
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Development of a Digital Microfluidic Lab-on-a-chip for Analysis of Atmospheric Inorganic Ions
A microfluidic device consisting of a Lab-on-Chip (LoC) was designed for on-line analysis of sulfate, ammonium and nitrate in atmospheric air samples. The LoC has the ability to integrate and automate collection (via impaction), extraction and analytical detection of these three major inorganic …
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An artificial experimenter for automated response characterisation
Biology exhibits information processing capabilities, such as parallel processing and context sensitivity, which go far beyond the capabilities of modern conventional electronic computation. In particular the interactions of proteins such as enzymes are interesting, as they appear to act as …
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