Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"LLPS"”.
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MOLECULAR MECHANISMS OF ATP-MODULATED LIQUID-LIQUID PHASE SEPARATION (LLPS) OF TDP-43 AND SARS-COV-2 NUCLEOCAPSID PROTEIN
An estimated 40% of human proteome has undergone LLPS; delineating its molecular mechanisms may reveal principles undiscovered in physiology and open avenues for pathology. All living cells inexplicably maintain 2-14 mM ATP. Strikingly, in 2017, ATP (> 5 mM) was demonstrated to behave as a …
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The Phase Behavior of Ubqln Proteins and Implications for Protein Quality Control
… and undergoes liquid-liquid phase separation (LLPS) in vitro. LLPS is a biophysical process by which proteins separate themselves from the surrounding aqueous solution by forming protein-rich droplets. The overarching goals of this work are to understand how the UBQLN family of proteins form …
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Investigating the dynamic nature of biomolecular condensates that support rotavirus replication
… is driven by liquid-liquid phase separation (LLPS) of an intrinsically disordered phosphoprotein NSP5, which acts as a scaffold, along with the RNA chaperone NSP2 as the major client biomolecule. While viroplasms have been recognised as ribonucleoprotein condensates that serve as replication …
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Characterizing Multivalent Interactions Between Folded Protein Domains and Intrinsically Disordered Regions or Peptide Substrates
… that mediate the liquid-liquid phase separation (LLPS) of ubiquilin-2 (UBQLN2). UBQLN2 is a shuttle protein for the proteasome that functions by binding to proteasomal receptors and ubiquitinated substrates via its N-terminal ubiquitin-like (UBL) and C-terminal ubiquitin associated (UBA) domains, …
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A Search for Neutral Long-Lived Particles Decaying into Displaced Jets in the ATLAS Calorimeter in Proton-Proton Collisions at the LHC
A search for neutral long-lived particles (LLPs) decaying in the ATLAS hadronic calorimeter using 140 fb^-1 of proton proton collisions at √s = 13 TeV delivered by the LHC is presented. The analysis targets pair-produced LLPs where at least one LLP is produced with sufficiently low boost that its …
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MOLECULAR MECHANISMS OF THE FORMATION OF ENDOCYTIC PATCHES AND THE INITIATION OF ACTIN POLYMERIZATION IN FAST ENDOPHILIN MEDIATED ENDOCYTOSIS
… integral role of liquid-liquid phase separation (LLPS) in various steps of FEME facilitating precise spatiotemporal recruitment of key endocytic machinery and the regulation of actin polymerization. We demonstrate that the major FEME regulator endophilin (EDP), undergoes LLPS with key binding …
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Forecasting and strategic inventory placement for gas turbine aftermarket spares
… of forecasting demand for Life Limited Parts (LLPs) in the gas turbine engine aftermarket industry. It is based on work performed at Pratt & Whitney, a major producer of turbine engines. The author worked in the Global Materials Solutions program, Pratt & Whitney's latest business venture, in …
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β2-mikroglobulino gryninimas ir skysčio-skysčio fazių atsiskyrimo tyrimai /
… of research is liquid-liquid phase separation (LLPS), the process by which proteins and other biomolecules separate from the bulk solution to form dense, membraneless condensates. Although dozens of proteins have been identified to form condensates, there is currently no information on whether …
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Dissolution Behavior of Amorphous Solid Dispersions
… namely liquid-liquid phase separation (LLPS). LLPS creates a discrete drug-rich phase dispersed in the continuous aqueous drug-lean phase and is expected to impact the bioavailability of the drug though effects on diffusion and crystallization behavior. Currently there is a lack of …
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VUV laser-induced plasma spectroscopy for low level sulphur detection in steel
… sensitively quantify sulphur content in steels. LlPS is a well-established method for both quantitative and qualitative analysls of solids, liqurds and gases A particular problem exists with the elemental characterisation of the light elements (2 < 20) including sulphur in that the strongest …
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Quantitative analysis of protein liquid-liquid phase separation
… This process of liquid–liquid phase separation (LLPS) has emerged as a crucial mechanism for describing the production of biological condensates in live cells, which have been found to be critical to a number of biological functions and activities. In this thesis, I have focused on the …
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Phase Separation Mediated Compartmentalisation of Rotavirus Replication
Liquid-liquid phase separation (LLPS) of biopolymers is a fundamental mechanism underlying the formation of cytoplasmic inclusions that function as sites of genome replication and viral particle assembly in rotaviruses. Intrinsically disordered proteins are key drivers of LLPS. In rotaviruses, the …
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RNA-MEDIATED PHASE SEPARATION OF 53BP1: CONNECTING CONDENSATE BIOPHYSICS TO DNA DAMAGE RESPONSE
… can form via liquid-liquid phase separation (LLPS) where biochemical reactions concentrate within the cell. An example of such condensates are DNA damage response (DDR) foci, proteins and RNA assemblies where DNA damage signaling and repair occur. We previously demonstrated that the DDR …
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Decoding the Sequence-Dependent Properties of Intrinsically Disordered Proteins
… homogenous liquid-liquid phase separation (LLPS) under certain conditions, however variations in salt concentration have been shown to have disparate effects and can even enhance phase separation beyond 1 M NaCl. Through the lens of A1-LCD we simulate an 8-chain model in low- to high-NaCl …
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Multiscale coarse-grained models for biological phase separation: Development and applications
… proteins undergo liquid–liquid phase separation (LLPS) in order to generate membraneless organelles, by which the cell can organise its biomolecules and bioprocesses dynamically in space and time. Many of the experimental and theoretical methodologies used to study the formation of these …
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Alterations in the phase behaviour of human γD-crystallin due to mutagenesis and chemical modification of the protein surface
… HGD undergoes liquidliquid phase separation (LLPS). The temperature (Tph) at which LLPS occurs can be used as a measure of the strength of attractive interactions between proteins in solution. The effects of chemically modifying specific amino acids (Lys-2 and Cys-110) on the surface of HGD …
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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions
… shown to promote liquid-liquid phase separation (LLPS) in vitro, suggesting a basis for the liquid-like behavior of nucleoli. Nucleophosmin (NPM1), a multifunctional and highly abundant nucleolar protein, exhibits structural features associated with LLPS suggesting a role in nucleolar …
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The functional characterization of a novel protein, Liat1
… called liquid-liquid phase separation (LLPS). This involves the reversible conversion of a homogenous solution into separate phases of distinct density through the condensation of one or more of its biomolecular components. This process results in the formation of membrane-lacking …
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Searching for signs of hidden sectors at the LHC: long-lived particle methods and models
… solved in theories of new long-lived particles (LLPs) in hidden sectors, but in practice the current search program may miss key data, especially for MeV-GeV range masses of transverse-boosted LLPs. The high-luminosity Large Hadron Collider (HL-LHC) will produce more data than any previous LHC …
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Learning Effective and Human-like Policies for Strategic, Multi-Agent Games
… communication in latent language policies (LLPs), in which high-level instructor and low-level executor agents communicate using natural language. While LLPs can solve long-horizon RL problems, past work has found that LLP training produces agents that use messages in ways inconsistent with …
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