Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"LINE1"”.
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LINE1 MODULATE HUMAN T CELL FUNCTION BY REGULATING PROTEIN SYNTHESIS DURING LIFE SPAN
… contenenti sequenze di retrotrasposoni LINE1. Abbiamo inoltre dimostrato che la riduzione di queste specie di RNA segna la transizione dalla queiscenza verso l'attivazione. In questo studio, abbiamo scoperto che lo stato di quiescenza delle cellule T naïve neonatali è caratterizzato da …
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Physical and genetical investigation of the Xp11.3 region on the short arm of the human X-chromosome
… results obtained strongly suggest a link between LINE1 elements and X chromosome inactivation. Sequence analysis results also contributed to the understanding of difficulties with restriction mapping of the region. Further, this work includes the first reported establishment of the UBEl exonintron …
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Klonierung und molekulare Charakterisierung von Deletionsbruchpunkten bei juveniler Nephronophthise Typ 1
… wurde in Intron 2 des NPHP1-Gens innerhalb eines LINE1-Elementes lokalisiert. Der telomerische Bruchpunkt befand sich in der telomerischen 330 kb Sequenzduplikation. Durch Klonierung und Sequenzierung des Junktionsfragmentes wurden beide Bruchpunkte bis auf zwei Guanin-Nucleotide genau bestimmt. …
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RNA localizations of proteins that interact with the chromosome passenger complex
… delays the dispersal of Xist and may also impact LINE1. We were also able to visualize AURKB and Xist throughout mitosis. This study developed our understanding of daughter cell inheritance of ncRNA mediated transcriptional silencing by showing that multiple ncRNAs disperse from the nucleus after …
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Probabilistic modelling of somatic alterations in bulk tissue and single cells using repeat DNA
Chromosomal instability characterises several cancer types, in which large-scale structural alterations of the genome accumulate at an increased rate. An important class of structural alterations are somatic copy number alterations (SCNAs). SCNAs have been shown to be major drivers of oncogenesis …