Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"LDL Receptor"”.
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Klonierung, Expression und funktionelle Charakterisierung eines Minirezeptors aus der Domäne II des LDL Receptor Related Protein
Das LDL Receptor Related Protein (LRP) ist ein 600 kD großer multifunktioneller Rezeptor, der in der Leber stark exprimiert wird und Liganden aus dem Lipidstoffwechsel bindet. Zu Beginn dieser Arbeit war die Lage der Bindungsstellen von Liganden des Lipidstoffwechsels im LRP nur unzureichend …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… element binding proteins (SREBPs) and liver X receptors (LXRs). This thesis describes the identification by microarray technology of novel genes in cholesterol metabolism and the characterization of two of these genes. Microarray analysis of the livers of mice fed a low versus high cholesterol …
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Post-translational processing of the low density lipoprotein receptor
The low density lipoprotein (LDL) receptor is a transmembrane glycoprotein that mediates the uptake of plasma LDL and thereby provides cholesterol to cells. During its synthesis in the endoplasmic reticulum, the LDL receptor folds and forms disulfide bonds in multiple cysteine-rich repeats. N- and …
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Monogenic hypercholesterolemia in South Africans : familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100
LDL-receptor mutations and familial defective apolipoprotein B-100 (codon 3500) (FOB), the known causes of monogenic hypercholesterolemia (MH), have similar clinical features. The nature of the mutations responsible for MH in South Africans of Indian origin was previously unknown. Similarly, the …
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Lipoprotein receptors in cultured bovine endothelial cells
… which have been modified by acetylation (AcLDL). In this study, receptors that may be involved in the uptake of these lipoproteins were characterized. The cells used were aortic endothelial cells obtained from a bovine foetus, with subsequent cloning (A₃Cl₂). A cell culture system which …
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The expression and metabolism of low density lipoprotein receptors in familial hypercholesterolaemia
The expression of two phenotypically-contrasting LDL receptor mutations was characterized in cultured fibroblasts from the genetically-homozygous Afrikaner subjects, FH1a and lb, and FH3a and 3b, respectively. Surface receptor expression and functional activity were studied by ligand (¹²⁵I-LDL) and …
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The cellular degradation of the low density lipoprotein receptor and its ligand
… degradation of the low density lipoprotein (LDL) receptor, and its ligand, LDL, were investigated in order to clarify certain mechanistic aspects of these important processes. Long-term lymphoblastoid cell lines and cultured human skin fibroblasts were used to examine the fate of ¹²⁵I-LDL …
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The Molecular and Cellular Mechanisms for Nanoparticle Transport
… in the body. We discovered that cells use the LDL receptor to bind the apolipoprotein B and complement C8 proteins adsorbed on the nanoparticle surface to take up nanoparticles. Expression in the LDL receptor correlated with and thus predicted the amount of nanoparticle accumulation in mice …
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Receptor-mediated endocytosis of low density lipoproteins in aortic endothelial cells
… and by indirect immunofluorescence microscopy. LDL and acetylated-LDL (AcLDL) were seen bound to the surfaces of subconfluent ECs (at 4°C or at 37°C), as a random distribution of punctate foci. ECs therefore closely resembled fibroblasts in the distribution of LDL receptors on their surfaces. No …
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The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa
Monogenic defects in the low density lipoprotein (LDL) uptake pathway occur commonly in South Africans, particularly in the Afrikaner community where inheritance is typically autosomal dominant, arising predominantly from abnormal structure and thus function of the LDL receptor (LDLr). Defects in …
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The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
<p>Plasma low-density lipoprotein (LDL) levels are positively correlated with the incidence of coronary artery disease. In the circulation, the plasma LDL clearance is mainly achieved by the uptake via LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (<em>PCSK9</em>) is a newly …
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Role of Macrophage Apoptosis in Atherosclerosis.
… of atherosclerosis, fourteen 8-week-old male LDL-receptor null (LDLR-/-) mice were lethally irradiated and reconstituted with either wild type (WT) C57BL6 or Bax-/- bone marrow. Three weeks later, the mice were challenged with a Western diet for 10 weeks. No differences were found in the …
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The Role of Apolipoprotein A-I in the Modulation of Cholesterol and Immune Homeostasis
… autoimmunity. We used a mouse model lacking the LDL receptor and the apoA-I gene (LDLr-/-,ApoA-I-/- or DKO). LDLr-/- (SKO) mice were used as controls. When fed a cholesterol-containing diet, DKO mice exhibited cholesterol accumulation in the skin and skin-draining lymph nodes (LNs). The LN total …
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Dissecting the Molecular Basis of the Antiphospholipid Syndrome
… against beta 2GPI, mimics the effects of aPL. Receptor-associated protein or RAP, an antagonist of the LDL receptor (LDLR) family, fully prevents aPL antagonism of eNOS in endothelial cells. Moreover, eNOS antagonism by aPL as indicated in vivo in carotid vascular conductance studies is absent …
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Regulation and Function of Apoer2 and Vidlr in the Central Nervous and Reproductive Systems
The LDL receptor gene family is an evolutionarily ancient family of membrane spanning proteins composed of a diverse collection of receptors that share common domains and mediate a variety of organismal functions. Members of this family, Apoer2 and Vldlr, are highly similar receptors and are both …
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Development of polymeric nanoparticle vaccines for immunostimulation
… a plasma protein that plays an important role in LDL cholesterol (LDL-c) levels in the blood, our nanoparticle allows selective orientation through biotin-streptavidin conjugation. Upon vaccination with CPG, selected synthetic epitopes conjugated to polymeric nanoparticles trended to reduce serum …
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… member of the low density lipoprotein family of receptors, is sorted apically in polarized epithelial cells via a sorting signal present in its cytosolic domain. I show that the cytosolic domain of megalin associates with sorting nexin 17, a protein that interacts with all core members of the low …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
… earlier age of onset of AD. A synaptic ApoE receptor, Apoer2, activates Dab1 and Src family tyrosine kinases (SFKs) upon binding to the extracellular ligand Reelin. Here, we show that this Reelin-Apoer2-Dab1-SFKs signaling complex greatly enhances the tyrosine phosphorylation as well as the …
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Anti-hyperlipidemic activities of Ilex latifolia and other selected herbs
… elevated levels of lipoproteins especially LDL-cholesterol and this is the most common form of dyslipidemia. Hyperlipidemia is the result of complex interactions between environmental and genetic factors. Hyperlipidemia is the main cause of congestive heart diseases in adulthood. It is also …
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