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Showing 1 to 20 of 370 for “"LDL"”.

  1. Analyse der Low-Density-Lipoproteine (LDL) : kann die LFE die UZ-Fraktionierung von LDL ersetzen?

    Knothe, Ingrid

    … worden, dass von den Low-Density-Lipoproteinen (LDL) besonders die Subfraktionen mit kleinen, dichten Partikeln mit einem erhöhten Risiko für Herz-Kreislauferkrankungen assoziiert sind. <br>Um diese besonders atherogenen LDL-Partikel diagnostisch zu erfassen, ist eine Auf­trennung in …

    freiburg-diss Repository record

  2. Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels

    Maxwell, Kara Noelle

    … down-regulates low density lipoprotein receptor (LDLR) levels leading to elevated plasma LDL cholesterol. Furthermore, it was determined that Pcsk9 induces the degradation of the LDLR by a non-proteasomal mechanism in a post-ER compartment. One of the up-regulated genes, A disintegrin and …

    rockefeller Repository record

  3. Untersuchung der Effektivität, Selektivität und Verträglichkeit von DALI-LDL-Apherese bei hohen Blutflüssen

    Schilling, RalfLudwig-Maximilians-Universität

    … Kompatibilität zu Vollblut gegenüber anderen LDL- Apherese Verfahren aus. Die bisher in Studien untersuchten und herstellerseitig zugelassenen Blutflussraten von 60 und 80 ml/min führen in der Regel zu einer Behandlungsdauer pro Behandlung von etwa 2 Stunden. Die hier vorgelegte Studie sollte …

    lmu-germany Repository record

  4. The Influence of Lipid Composition on the Binding of LDL to Chondroitin 6-Sulphate

    Espiritu, Wilma2014

    The interaction between low-density lipoprotein (LDL) and glycosaminoglycans is a key factor in atherosclerosis. The present study examines the characteristics of LDL and its binding properties with the main glycosaminoglycan of the vascular wall, chondroitin 6- sulphate (C6S). The compositional …

    vcu Repository record

  5. Klonierung, Expression und funktionelle Charakterisierung eines Minirezeptors aus der Domäne II des LDL Receptor Related Protein

    Schlemmer, Erika

    Das LDL Receptor Related Protein (LRP) ist ein 600 kD großer multifunktioneller Rezeptor, der in der Leber stark exprimiert wird und Liganden aus dem Lipidstoffwechsel bindet. Zu Beginn dieser Arbeit war die Lage der Bindungsstellen von Liganden des Lipidstoffwechsels im LRP nur unzureichend …

    freiburg-diss Repository record

  6. Transport Pathway across HCAECS uncer convective condtitions and The role of apoptosis in LDL transport through HCAECS

    Phupeerasupong, Janpen

    cuny Repository record

  7. Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes

    Bower, Joseph Louis2025

    … fatty acid docosahexaenoic acid (DHA). The LDL-DHA nanoparticle has demonstrated cancer selective cytotoxicity with little ill effects on healthy cells. Our research began by selecting a panel of breast cancer cell lines representative of the various subtypes of clinical breast cancer. This …

    utswmed Repository record

  8. Inhibitory Effects of Ketoconazole on the Oxidation of Linoleic Acid Micelles, Phospholipid Liposomes, and Human Low Density Lipoprotein (h-LDL)

    Munroe, Melissa E.Drake University1993

    … extracts of bovine brain (2.5 mg/ml), and h-LDL (0.5 mg/ml). Oxidation of the lipid substrates was determined by the formation of thiobarbituric acid reactive substances and conjugated dienes. Free iron (Fe(III)Cl3/ascorbate) was the strongest initiator, followed by hematin and SLO. …

    drake Repository record

  9. Die Auswirkungen von Atorvastatin versus Fenofibrat auf Lipoproteinprofil, LDL-Subtypenverteilung, Entzündungsmarker und hämorheologische Paramter bei Typ-2-Diabetikern mit gemischter Hyperlipoproteinämie

    Frost, RobertLudwig-Maximilians-Universität

    lmu-germany Repository record

  10. Analyse von Proteinen und deren Elimination durch drei verschiedene extrakorporale Therapieverfahren der LDL-Apherese bei Patienten mit familiärer Hypercholesterinämie mittels Proteomics-Methoden

    Söllner, Tanja2012

    … die Analyse der durch verschiedene Verfahren der LDL-Apherese gefilterten Proteine mittels Proteomic-Methoden. Hierzu untersuchten wir Patienten mit familiärer Hypercholesterinämie und regelmäßiger Behandlung mit LDL-Apherese. Diese Patienten haben krankheitsbedingt einen erhöhten …

    goettingen Repository record

  11. Pengaruh pemberian ekstrak buah jambu biji (Psidium guajava.L) terhadap kadar kolesterol total, HDL,LDL, dan trigliserida darah tikus putih (Rattus norvegicus) yang diinduksi aloksan

    Islamiyah, DenikUniversitas Islam Negeri Maulana Malik Ibrahim2010

    … menghalangi adanya reaksi oksidasi kolesterol LDL dalam tubuh. Tujuan dari penelitian ini adalah untuk mengetahui efek ekstrak buah jambu biji terhadap kadar kolesterol total, HDL,LDL, dan Trigliserida darah tikus yang diinduksi aloksan. Penelitian ini bersifat eksperimental dengan Rancangan …

    malang Repository record

  12. The Effects of Ketoconazole on the Oxidation of Low Density Lipoproteins by Bovine Aortic Smooth Muscle Cells

    Zentrich, EveDrake University1993

    … modify human low-density lipoprotein (LDL). Such oxidized LDL appears to be a significant factor in the etiology of atherosclerosis. This work shows that the azole antifungal drug ketoconazole when added to the culture medium of BASMC inhibits LDL oxidation. Confluent BASMC were fed 1 …

    drake Repository record

  13. Lectin-like oxidized LDL receptor-1 (LOX-1) supports adhesion of mononuclear leukocytes and a monocytic-like cell line THP-1 cells under static and flow conditions

    Hayashida, KazutakaKyoto University2003

    kyoto Repository record

  14. Modification of Low Density Lipoprotein and the Effects of Modified Low Density Lipoproteins on the Endocytic and Secretory Repertoire of the Macrophage

    Montgomery, Ruth Rebecca

    … between modified low density lipoprotein (LDL) and macrophages in the initiation and development of the atherosclerotic lesion. The first of these concerns the observed biological modification of LDL that leads to its subsequent enhanced uptake by macrophages, and the role of oxidation in …

    rockefeller Repository record

  15. The cellular degradation of the low density lipoprotein receptor and its ligand

    Casciola, Livia Angela FlaviaDivision of Medical Biochemistry and Structural Biology1987

    … degradation of the low density lipoprotein (LDL) receptor, and its ligand, LDL, were investigated in order to clarify certain mechanistic aspects of these important processes. Long-term lymphoblastoid cell lines and cultured human skin fibroblasts were used to examine the fate of ¹²⁵I-LDL …

    cape-town Repository record

  16. Lipoprotein receptors in cultured bovine endothelial cells

    Strumpfer, A E MDivision of Medical Biochemistry and Structural Biology1983

    … which have been modified by acetylation (AcLDL). In this study, receptors that may be involved in the uptake of these lipoproteins were characterized. The cells used were aortic endothelial cells obtained from a bovine foetus, with subsequent cloning (A₃Cl₂). A cell culture system which …

    cape-town Repository record

  17. Receptor-mediated endocytosis of low density lipoproteins in aortic endothelial cells

    Sanan, David AustinDivision of Medical Biochemistry and Structural Biology1986

    … and by indirect immunofluorescence microscopy. LDL and acetylated-LDL (AcLDL) were seen bound to the surfaces of subconfluent ECs (at 4°C or at 37°C), as a random distribution of punctate foci. ECs therefore closely resembled fibroblasts in the distribution of LDL receptors on their surfaces. No …

    cape-town Repository record

  18. Effekte des oxidativen Stresses auf die Expression der Scavenger-Rezeptoren CD36 und SR-BI und des Transkriptionsfaktors PPARγ in Makrophagen

    Westendorf, ThomasTechnische Universität Dresden

    … Effekte des oxidativen Stresses in Form von oxLDL auf die Expression der atherogenen Scavenger-Rezeptoren CD36, SR-BI, des Transkriptionsfaktors PPARγ und pro-inflammatorischer Zytokine zu untersuchen. Die durchgeführten Untersuchungen beruhen auf der Annahme, dass modifizierte LDL durch …

    qucosa-diss

  19. Post-translational processing of the low density lipoprotein receptor

    Ozinsky, AdrianDivision of Medical Biochemistry and Structural Biology1996

    The low density lipoprotein (LDL) receptor is a transmembrane glycoprotein that mediates the uptake of plasma LDL and thereby provides cholesterol to cells. During its synthesis in the endoplasmic reticulum, the LDL receptor folds and forms disulfide bonds in multiple cysteine-rich repeats. N- and …

    cape-town Repository record

  20. A novel pathway for VLDL assembly in the mouse liver

    Mleczko, Anna2012

    Es wird davon ausgegangen, dass LDL von der Leber und von peripheren Zellen endozytiert und vollständig abgebaut wird. Mit Hilfe primärer Maushepatozyten, durch Mausleberperfusion und durch intravenöse Injektion von LDL an Mäusen wird in der vorliegenden Dissertationsschrift gezeigt, dass als LDL …

    goettingen Repository record

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