NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 41 for “"Kinetic resolution"”.

  1. ALDOL COUPLINGS OF CHIRAL FRAGMENTS WITH KINETIC RESOLUTION: SCOPE AND LIMITATIONS

    kazemeini, aliehUniversity of Saskatchewan2013

    … of the four enantioenriched diastereomers 8 with kinetic resolution (KR) is possible with rational design of the reaction using the 'multiplicativity' rule. Thus, any of two of the eight possible aldol adducts, 72 or 73, are selectively available from the same reactants.

    sask Repository record

  2. ASYMMETRIC ORGANOCATALYTIC HENRY REACTION OF β–SUBSTITUTED α-KETO ESTERS VIA DYNAMIC KINETIC RESOLUTION

    LIU GUANNAN2012

    … derived bifunctional catalyst via dynamic kinetic resolution. Chapter 1 presents a brief historical background and development of asymmetric catalysis. Particularly, the asymmetric organocatalysis is introduced in detail. Then the historical background and development of dynamic kinetic …

    nus Repository record

  3. Multiple Kinetic Resolution of Tetrathia[7]helicenes. Towards the Study of Two Photon Circular Dichroism.

    Doulcet, JulienUniversity of East Anglia2014

    … derivatives using a newly developed multiple kinetic resolution (multi-KR) approach. The derivatives obtained (formyl- and diformylhelicene) should also be useful intermediates for the synthesis of chiral push-pull systems. The first part of the project was devoted to the synthesis of …

    east-anglia Repository record

  4. Producing Enantiopure Secondary Alcohols via a Silylation based Kinetic Resolution and a One-Pot Polishing Sequence

    Moore, Maggie Iris

    … one-pot polishing procedure and through kinetic resolutions via silylation and desilylation. Chapter 2 highlights how we have combined a moderately selective asymmetric reaction (either a reduction or allylation) with a kinetic resolution (via acylation or silylation) to generate …

    south-carolina Repository record

  5. Kinetic Resolution of N-Acyl-b-Lactams, b-Lactams, and N-Acyl-Thiolactams using Amidine-Based Catalysts

    Bumbu, Valentina Dumitru2014

    … acylation catalyst and thus can be termed as "kinetic resolutions" or KR. Considerable progress has been done in the Type I transformation, where chiral alcohols, thiols, and amines are achieved with great selectivities via asymmetric enzymatic and non-enzymatic acylation. KR of chiral acyl …

    wustl Repository record

  6. Synthesis of acetogenin analogues. Asymmetric transfer hydrogenation coupled with dynamic kinetic resolution of α-amido-β-keto esters

    Villo, Piret2013

    tartu

  7. Studies on the use of peptide auxiliaries in the meso-desymmetrization of epoxides, and the kinetic resolution of secondary alcohols

    Cozett, Rudy EdgarDepartment of Chemistry2015

    … Meso-desymmetrization of an epoxide and the kinetic resolution of secondary alcohols. Chapter 1 comprises a literature review, which gives a general overview of methods of asymmetric synthesis, followed by an overview on the existing classes of asymmetric DMAP-type acyl-transfer catalysis as …

    cape-town Repository record

  8. The Kinetic Resolution of Secondary Alcohols Through A Tandem Enantioselective Silylation and the Synthesis of Bis(Oxazolidinyl)Pyridine Metal-Organic Complexes

    Patel, Sachin Girish

    … diastereomers. The second step involves a kinetic resolution of these diastereomers via enantioselective silylation. This reaction is the first example of a kinetic resolution of secondary alcohols through a tandem sequence. This work then inspired us to design a `clean-up' reaction: where …

    south-carolina Repository record

  9. Density functional theory investigation into mechanisms of metal ion-promoted and base-promoted phosphorothioate cleavage reactions and Lanthanide ion catalysts for kinetic resolution of amino acid esters

    Maxwell, Christopher2012

    … ligands and their use as catalysts for the kinetic resolution of the 4-nitrophenyl esters of N-Boc glutamine and phenylalanine through an enantioselective methanolysis/ethanolysis reaction. Catalysts were screened in various solvents and temperatures to optimize the selectivity value k2L/k2D …

    queens Repository record

  10. Part I. Anionic Acyl Transfer Catalysis;Part II. Enantioselective alcoholysis of Acyl Donors;Part III. Enantioselective N-acylation

    Yang, Xing2013

    … which may be useful, e.g., for catalytic kinetic resolution of chiral amines.</p><p>From 2003 to 2009, our group developed four generations of amidine-based enantioselective acyl transfer catalysts(ABCs) and applied them successfully to the kinetic resolution of chiral alcohols. Compared …

    wustl Repository record

  11. Applications of planar-chiral heterocycles in asymmetric catalysis

    Tao, Beata, 1973-Massachusetts Institute of Technology2002

    … were investigated. Reactions including the kinetic resolution of propargylic alcohols, the enantioselective ring opening of meso epoxides, and the asymmetric hydrosilylation of ketones were studied. ... During the past few years, our group has developed lb as one of the most effective and …

    mit Repository record

  12. Asymmetric Syntheses With (-)-Sparteine-Complexed Benzylic and Allylic Organolithium Reagents

    Lim, Sung HyunUniversity of Illinois at Urbana-Champaign2015

    The kinetic resolution of racemic cyclic unsaturated esters with the organolithium intermediates derived from lithiation of N-Boc- N-(p-methoxyphenyl)cinnamylamine with n -BuLi/(-)-sparteine was investigated. Kinetic resolution in conjugate addition reactions with alpha,beta-unsaturated lactones …

    uiuc Repository record

  13. RECENT ADVANCES IN IMINIUM SALT CATALYSED ASYMMETRIC EPOXIDATION

    Day, DavidUniversity of East Anglia2013

    … the application of this reaction towards the kinetic resolution of racemic olefins. Chapter two is separated into two key areas; (i) asymmetric epoxidation as a tool in the kinetic resolution of racemic chromene substrates, and (ii) investigations into the asymmetric epoxidation of new …

    east-anglia Repository record

  14. Optimisation of chemoenzymatic processes in asymmetric synthesis

    Deasy, Rebecca E.University College Cork2012

    … enantio- and chemoselectivities enabling the resolution of organic substrates with superb efficiency and selectivity. In this study three biocatalytic applications in enantioselective synthesis were explored and perhaps the most significant outcome of this work is the excellent …

    cork Repository record

  15. Part 1: Progress Toward the Total Synthesis of Platensimycin. Part 2: Aromatic Ions: Carbon-Based Nucleofuges and Chiral Cyclopropenones and Formamides

    Fisher, Ethan Lawrence2011

    … of chiral cyclopropenones and formamides for the kinetic resolution of alcohols by chlorodehydration. The first chapter describes efforts in the total synthesis of platensimycin. The synthesis attempted to use a thermal rearrangement, through a biradical intermediate, and then radical induced …

    columbia-diss Repository record

  16. Synthesis and enzymatic resolution of amino acid esters in "green" solvents -- ionic liquids

    Zhao, Hua

    … optically pure amino acids by enzymatic resolution using a "green" solvent, named an ionic liquid. Ionic liquids, a new type of "green" solvents, have been used in many organic reactions and other chemical processes (such as liquid-liquid extraction) with improved performance. This is …

    njit Repository record

  17. Progress in transition metal-based enantioselective catalysis

    Arp, Forrest OMassachusetts Institute of Technology2008

    … and 1.3). In Chapter 2, the first method for the kinetic resolution of indolines through catalytic Nacylation is described (eq 2). To improve the selectivity factor, a new planar-chiral PPY-erived catalyst (2.1) was prepared, wherein the chiral environment had been modified. The method was applied …

    mit Repository record

  18. Copper-catalyzed conjugate reduction

    Jurkauskas, Valdas, 1966-Massachusetts Institute of Technology2004

    … to excellent yields (42-91%). Chapter 2. Kinetic resolution, with good selectivity factors (25-52), was achieved by conjugate reduction with catalytic CuCl/NaOt-Bu/(S)-p-tol-BINAP and stoichiometric quantities of PMHS. When stoichiometric amounts of NaOt-Bu and t-BuOH were included in the …

    mit Repository record

  19. Parallel kinetic resolutions using active esters

    Coulbeck, EliotUniversity of Hull2009

    … importance in modern organic chemistry; the resolution of racemic compounds is a very useful and practical method of achieving this. Parallel kinetic resolutions are an interesting variation on the more classical resolution methods; this method has been recently introduced to the scientific …

    hull Repository record

  20. Total synthesis of cis-sylvaticin and synthetic studies towards the synthesis of adjacent THF-THF and THF-THP Annonaceous acetogenins

    Spurr, Ian BruceUniversity of Southampton2010

    … Notable steps included the alcoholytic kinetic resolution of epoxide<br/>2.2, two permanganate promoted oxidative cyclisation reactions, a tethered<br/>RCM to unite the two major fragments and the use of P4 phoshazene base to<br/>install the butenolide precursor.<br/><br/>Synthesis of …

    soton Repository record

Page 1 of 3