Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1020 for “"Kinases"”.
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Roles for motifs of cell cycle regulating kinases beyond substrate selection of individual kinases
… and cancer formation. Several protein kinases, including the major mitotic kinases Cdkl, Aurora A, Aurora B, Nek2, and Plkl, and the Polo-like kinase (Plk) family, Plkl, Plk2, Plk3, and Plk4, are known to play important roles in the regulation of mitosis and other phases of the cell …
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Meiotic regulation of cyclin-dependent kinases
During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together. Determining how this unusual chromosome segregation behavior is …
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With No Gly-Loop Family of Kinases
… functions we hypothesized that PV resident kinases must regulate PV/IVN functions. Protein kinases are enzymes that modify proteins with phosphate molecules. Using bioinformatics, we identified an unusual family of kinases (WNG kinases) that lack a structural motif, called the Gly-loop, that …
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Structure-function analysis of phototropin receptor kinases
… of phototropins to act as light-regulated kinases is well established, the mechanism by which this occurs remains unclear. In this study a baculovirus/insect cell expression system is used to further characterise the mode of phototropin autophosphorylation and the functionality of a mutated …
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Analysis of cyclin dependent kinases in Leishmania
… to further explore the role of cyclin dependent kinases and cyclins in the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle phases and promote parasite proliferation during infection. In chapter 3 …
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Protein phosphatases and protein kinases in dictyostelium
… phosphate (pnpp) phosphatases and 2 protein kinases from <i>Dictyostelium</i> are described. .Two of the protein phosphatases are shown to have subunit structures. All of the protein phosphatase activities described were able to dephosphorylate sites on proteins that had previously been …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
The epidermal growth factor receptor: EGFR) is a membrane receptor tyrosine kinase whose over-activation has been implicated to cause many human cancers. Novel strategies to inhibit the activation of EGF receptors other than the conventional antibody-based and tyrosine kinase inhibitors are …
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The role of sphingosine kinases in pulmonary fibrosis
… that regulate this transition. Sphingosine kinases (SK) are promising new targets for pulmonary fibrosis as they regulate the balance between the proapototic ceramides and prosurvival sphingosine 1-phosphate. Sphingosine kinase 1 has a profibrotic role whilst the role of sphingosine kinase 2 …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… are regulated by cellular signaling, and kinases are central enzymatic players in hormone-induced cellular signaling. A dysfunctional adipose tissue can contribute to insulin resistance in many obese individuals. Therefore it is important to elucidate the cellular mechanisms that govern …
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Protein kinases that phosphorylate 14-3-3 isoforms
14 -3 -3 is an abundant, predominantly phospho-binding protein, intimately involved in the regulation of many diverse signal transduction events including cell cycle regulation, nucleo-cytoplasmic targeting of essential transcription factors and regulation of catecholamine synthesis. The 14 -3 -3 …
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Protein O-Kinases in the Archaeon Sulfolobus solfataricus
… of the structure and properties of the protein kinases resident in the members of the <i>Archaea</i> represents a key piece of this puzzle. The extreme acidothermophilic archaeon, <i>Sulfolobus solfataricus</i>, exhibits a membrane-associated protein kinase activity. Solubilization of the kinase …
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Regulation of Toxoplasma Motility by Calcium-Dependent Protein Kinases
… and plants, possess calcium-dependent protein kinases: CDPKs) that are directly activated by calcium binding and have been proposed to participate in the transduction of calcium signals. A number of CDPKs are conserved among apicomplexans, and showed distinct subcellular localizations upon …
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WNK Family Kinases and the Regulation of Ion Flux
… or WNK family of serine/threonine protein kinases have an unusual arrangement of their catalytic lysines. WNK1 and WNK4 have been genetically linked to a rare type of hypertension. Studies demonstrate that these kinases regulate the activity of a diverse group of proteins that in toto …
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α-Synuclein phosphorylation and related kinases in Parkinson’s disease
… phosphorylated at serine 129 (S129P). Several kinases have been suggested to facilitate α-synuclein phosphorylation in PD, but without significant human data the changes that precipitate such pathology remain conjecture. The major aims of this project were to assess the dynamic changes of …
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Determining the substrates for MAP kinases in Leishmania mexicana
… is essential. Mitogen-activated protein (MAP) kinases present a potential target; fifteen different MAP kinases have been found in L. mexicana, some of which have proven to be essential at various stages in the Leishmania life cycle. This project focuses on identifying substrates for three of …
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