Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Ketoconazole"”.
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… chemical screen approach, we found that ketoconazole, an FDA-approved azole antifungal, was able to kill tGLI1-expressing cancer cells with increased efficacy against the CSC subpopulation. Additionally, ketoconazole selectively inhibited the progression of tGLI1-positive BCBM in vivo. …
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The Effects of Ketoconazole on the Oxidation of Low Density Lipoproteins by Bovine Aortic Smooth Muscle Cells
… This work shows that the azole antifungal drug ketoconazole when added to the culture medium of BASMC inhibits LDL oxidation. Confluent BASMC were fed 1 ml of F- 12/DMEM containing LDL (320 ug protein). The cells over a 24 hour period caused a 2x increase in LDL oxidation as measured by an …
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Inhibitory Effects of Ketoconazole on the Oxidation of Linoleic Acid Micelles, Phospholipid Liposomes, and Human Low Density Lipoprotein (h-LDL)
… initiator, followed by hematin and SLO. Ketoconazole (KC) attenuated lipid oxidation in a concentration dependent manner at pharmacologically relevant levels (25-100microM) in all three substrates. Pretreatment of liposomes and h-LDL with KC produced greater attenuation of lipid oxidation …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… solid dispersions containing felodipine (FEL) or ketoconazole (KTZ) using hot-melt extrusion technology. The melting point depression approach was utilized to determine the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated higher solubility when …
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Susceptibility Testing of Pathogenic Fungi With a Radiometric System
… were Amphotericin B, 5-fluorocytosine, Nystatin, Ketoconazole, Miconazole, Terconazole, and Itraconazole. The instrument used to measure amount of radioactive carbon dioxide generated by fungal metabolism of ¹⁴C-glucose in presence of antifungal agents was the Bactex 460. Mycelial cultures were …
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Ionic Conductivity in Non-Ionic Compounds
… phenomenon. Polar solids like Lidocaine, Ketoconazole, Procainamide and Nifedipine were examined in this study. Experimental studies show an increase in ionic conductivity in both pre-melt (20 -30 °C below melting temperature) and melt transition regions. Results of ionic conductivity of …
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Vulvar Vestibulitis Syndrome: An Ultrastructural and Epidemiological Investigation
… over several months, and an evaluation of ketoconazole as a non-invasive treatment for VVS. Transmission electron microscopy, confirmed that vestibular epithelium was non-keratinised, and closely resembled oral and vaginal mucosae. Intermediate cells were predominant, characterised by pale …
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Silver (I) Complexes as Antimicrobial and Anticancer Drugs
… active than the prescription antifungal drug, Ketoconazole. This complex also exhibited high cytotoxicity towards bacterial cells, being ca. 9 times more active against both E. coli and MRSA than the known antibacterial agent, silver sulfadiazine. The hexanuclear imidazole complex, …
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Η επίδραση της κετοκοναζόλης στην ιδιοπαθή ορμονοεξαρτώμενη τριχοφυΐα
… appearance of a new steroidogenetic inhibitor ketoconazole gave us the opportunity to design the present study in order to examine any possible action of this new imidazole-derived agent in the treatment of idiopathic hirsutism. For this purpose 225 women with hirsutism were studied. The …
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Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques. Development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research.
… chromatography-mass spectrometry (HPLC-MS). A ketoconazole analogue and a 2-EN analogue, with known P450 inhibition, were immobilised on a solid support for comparison to immobilised histamine. Co-factor removal, competitive elution and DTT cleavage of disulfide bonds of probes were utilised to …
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The effect of additives on the molecular mobility, physical stability and dissolution of amorphous solid dispersions
… organic acids to stabilize an amorphous API, ketoconazole (KTZ), was next investigated. Oxalic (OXA), citric (CIT), tartaric (TAR) and succinic (SUC) acids were chosen based on their relative strengths (pKa values). Coamorphous systems of KTZ with each acid exhibited ionic and/or hydrogen …
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Solubility Enhancement via Melt Extrusion: Drug-polymer Solubility, Physicochemical Characterization and Quality by Design
… design space. Finally, mechanistic evaluation of Ketoconazole and Kollidon<super>®</super> VA 64 solid dispersions was performed using thermal techniques, dissolution, swelling and erosion studied.
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Effect of berberine on in vitro metabolism of sulfonylureas: a herb-drug interactions study
… metabolism of glyburide was investigated using ketoconazole and tienilic acid as the inhibitors of CYP3A and CYP2D at 0.01 to 1.5 μM and 0.005 to 100 μM, respectively, with glyburide at 20 μM in 0.5 mg/mL microsomes and the NADPH regenerating system. The role of CYP2C in metabolism of gliclazide …
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Detection and imaging of pharmaceutical compounds in skin by MALDI-MS.
… A calibration graph for the determination of ketoconazole was prepared using the sodium adduct of the matrix ion as an internal standard. This enabled construction of a quantitative profile of drug in skin. Conventional haematoxylin and eosin staining and microscopy methods were employed to …
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The development of novel metabolic therapies for the treatment of glioblastoma
… the prospective HK2 inhibitors posaconazole, ketoconazole, and xanthohumol lack selectivity towards their intended target. RNAseq of HK2 knockdown cell cultures revealed novel associations between HK2 and chronic inflammation, immune infiltration, and angiogenesis in the glioblastoma tumour …
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Progressing the Synthesis, Coordination Chemistry and Biological Evaluation of Phenanthrolines
… than the clinically used antifungal drug, ketoconazole. Against two different Mycobacterium tuberculosis strains, the Mn(II) complexes exhibited potent antimycobacterial activity, with 13 being 3-fold more active than the prescription drug, isoniazid. This Mn(II) complex was also highly …
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The use of glutathione in canine itraconazole-associated hepatotoxicity
… are itraconazole (ITZ), fluconazole (FCZ), and ketoconazole (KTZ). Owing to its greater selectivity for fungal ergosterol over mammalian cholesterol, ITZ has fewer adverse effects than KTZ. Additionally, it has a broader spectrum of activity than both KTZ and FCZ. For this reason, ITZ is used to …
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The interactions of Propafenone and its enantiomers with the major human forms of cytochrome P450 in terms of inhibition and metabolic rates
… – Tranycylpromine; CYP2D6 – Quinidine; CYP3A4 – Ketoconazole ; CYP1A2 - Furafylline). In vitro metabolism was conducted using human liver microsomes incubated with propafenone (racemate and enatiomers) and the degree of metabolism measured using hplc analysis. Protein binding was estimated for …
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Invitro antibacterial activity of imidazole and triazole-based antimicrobials against Carbapenem Resistant Enterobacteriaceae
Thesis submitted in fulfilment of the requirements for the degree of Masters of Technology: Biomedical Technology, Durban University of Technology, Durban, South Africa, 2017.