Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Kennedy Pathway"”.
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
… a direct link between specific molecular pathways and disease pathogenesis. The work described in this thesis entails clinical, genomic and cellular studies which advance scientific knowledge of the genetic and molecular processes important for motor neuron health and survival. Chapter …
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Metabolic engineering strategies for increasing lipid production in oleaginous yeast
… important to lipid production, including the Kennedy pathway, fatty acid synthesis, central carbon metabolism, NADPH generation, regulation, and metabolite transport. Our results demonstrate that a diverse subset of gene overexpressions led to significant improvements in lipid production on at …
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Investigating mechanisms of triacylglycerol synthesis induced by nitrogen depletion in the diatom Phaeodactylum tricornutum and characterising its diacylglycerol acyltransferases and phospholipid: diacylglycerol acyl transferase
… regulated genes supports involvement of central pathways and lipid metabolism in TAG accumulation: acetyl-CoA synthesis may increase while FA synthesis, the Kennedy pathway, malonyl-CoA/ACP transacylase, plastidial desaturase and FA transport enzymes were upregulated. Desaturases, elongases, …
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Pct1 regulates phosphatidylcholine synthesis in response to changes in surface curvature elastic stress sensed on the inner nuclear membrane
… The rate-limiting step of the predominant pathway for PC synthesis in eukaryotic cells is catalysed by the enzyme, CTP: phosphocholine cytidylyltransferase α (CCTα or PCYT1A). CCTα has a critical role in lipid metabolism and also has direct clinical relevance as mutations in CCTα result in …
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Determining biological roles of four unique Vernicia fordii acyl-CoA Binding Proteins
High-value industrial oils are essential for many processes and have great economic and environmental impacts. The tung tree produces a high-value seed oil. Approximately 80% of tung oil is α-eleostearic acid, which has a high degree of unsaturation thus giving it properties as a drying oil. The …
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Biochemistry in healthy and neoplastic human tissues: metabolic alteration revealed by HR-MAS nuclear magnetic resonance spectroscopy
… metabolites (tCho) and the expression of the Kennedy pathway genes in biopsies of human gliomas were also investigated using HR-MAS NMR, and microfluidic genomic cards. 1H HR-MAS spectra, allowed the resolution and relative quantification by LCModel of the resonances from choline (Cho), …