Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"KIR"”.
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Evaluation von KIR-Liganden Inkompatibilität bei unverwandten Knochenmark-/ Stammzelltransplantationen
… was to answer the question wether the benefit of KIR ligand incompatibility seen in haploidentical tranplantations can also be seen using unrelated donors. We could not detect a significant difference in survival between patients with a KIR ligand incompatibility and those with either fully …
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Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
<p>Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from …
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Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)
… der killer cell immunoglobulin like Rezeptoren (KIR) und die Interaktion zwischen KIR und MHC-Klasse-I Molekülen im Rhesusaffen (Macaca mulatta). In Menschen wurde gezeigt, dass KIR Haplotypen Auswirkungen auf die Resistenz gegen unterschiedliche Krankheiten haben. Der Rhesusaffe ist ein häufig …
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Development of An In Silico Kir Genotyping Algorithm and Its Application to Population and Cancer Immunogenetic Analyses
… determination and variant calling in the complex KIR genomic region are useful for immune system function analysis, pathogenesis and disease risk factor elucidation, immunotherapy development, evolutionary investigations, and human migration modeling. Sequence-specific oligonucleotide and …
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The pattern and functional consequence of Killer Immunoglobulin-like Receptor expression on T cells.
Killer immunoglobulin-like receptors (KIRs) are a family of proteins expressed on human natural killer cells and a subset of T cells. Several inhibitory KIRs have been shown to recognise MHC class I molecules (predominantly HLA-C), with their engagement preventing target cell lysis. The ligand(s) …
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Selbsttoleranz von NK-Zellen
… Das funktionelle Niveau liegt unter dem der KIR-tragenden NK-Zellen, jedoch sind sie nicht anerg. Für diesen Funktionszustand wurde von anderen der Begriff hyporesponsiveness geprägt. Weiterhin wurde in drei Donoren eine Zellpopulation identifiziert, welche zwar einen inhibitorischen KIR …
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Innate Lymphoid Cell Diversity in Pregnancy and Ovarian Cancer
… (EVT) including Killer-cell Ig-like receptors (KIR), LILRB1 and NKG2A. In contrast to dNK2 and dNK3, dNK1 respond poorly to ‘missing self’ and PMA plus ionomycin treatment. However, upon cross-linking of an activating KIR they can degranulate and produce cytokines/chemokines. dNK1 responsiveness …
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A Dual-Domain Peptide Strategy for Targeted Regenerative Repair
… from suppressor of cytokine signaling 1 (SOCS1; KIR), fused to a TAT cell-penetrating peptide (KIR-TAT) to promote intracellular delivery and attenuation of pro-inflammatory signaling pathways. Collectively, this dual-domain design seeks to confine therapeutic activity to the target tissue while …
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Selezione e processazione di cellule Natural Killer da donatore aploidentico "KIR-ligand" incompatibile per l'immunoterapia adottiva di pazienti con Leucemia Acuta Mieloblastica ad alto rischio
… termed killer immunoglobulin-like receptors (KIRs). In haploidentical T-cell depleted transplantation the donor/recipient KIR mismatch significantly impacts on NK-mediated tumor cell killing, particularly in acute myeloid leukaemia (AML). Thirty-four high risk AML patients entered a phase I-II …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
… on Killer-cell Immunoglobulin-like Receptors (KIRs), which are poorly studied in the field of γδ T cell biology. Because cytomegalovirus (CMV) is known to shape the αβ T cell and NK cell repertoires, I studied peripheral blood (PB) γδ T cells from both CMV-seronegative (CMV-) and …
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Multicomponent Heterocycle Syntheses Based upon Sonogashira Coupling-Isomerization
… der Kupplungƒ{Isomerisierungsƒ{Reaktion (KIR); Eintopf, MultikomponentSynthese von Heterozyklen
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Genetische Charakterisierung des "Leukocyte Receptor Complex" und Entwicklung einer Methode zum Nachweis seiner Produkte im Einzelzellmaßstab
… (ILT) und ‚killer cell Ig-like receptor′-Gene (KIR). Die KIR- und ILT-Cluster werden von weiteren stammesgeschichtlich verwandten Genen unterbrochen und flankiert. Je nach Individuum können im LRC bis zu 31 solcher verwandten Rezeptorgene lokalisiert sein. Auf der Grundlage der Kartierungsdaten …
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NKG2D Ligands in Cancer
… resistant despite high NKG2D ligand expression, KIR inhibition was found to override NKG2D activation in 80% of these cancers. MHC blockade successfully increased NK susceptibility of these cell lines. In the remaining 20%, downregulation of ICAM-1 was responsible for NK resistance. In …
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels.
… are inwardly rectifying potassium channels (Kir), which are inhibited by ATP and stimulated by magnesium bound nucleotides. The K ATP channel is an octomeric combination of two different protein subunits. The pore is formed by four Kir6.2 subunits, each of which is associated with a …
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
… muscle-specific inward-rectifying potassium (Kir) channel, Kir2.6, has been recently suggested to play a role in TPP. Here, I focus on studying the role of Kir channels in non-familial hypoPP and propose the disease mechanisms to explain hypokalemia and muscle paralysis. PHA2 is a genetic …
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The immunopathogenic mechanism of severe cutaneous adverse reactions to first line anti-tuberculosis drugs
… (ERAP) and Killer Immunoglobulin Receptor (KIR) genes along with HIV-related immune dysregulation during drug exposure might confer susceptibility. In this thesis, we aimed to identify genetic markers in African populations for FLTD-induced SJS/TEN and DRESS, and using single-cell proteomic …
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The role of uterine natural killer cell-inhibition in pregnancy
… notion that uterine NK cell inhibition driven by KIR: HLA interactions leads to poor pregnancy outcomes, was attempted.
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Molecular mapping of the rabbit atrioventricular node
… bundle compared to the atrium and ventricle. Kir 2.1 mRNA was significantly higher in the ventricular muscle compared to the PNE and atrial muscle. Atrial natriuretic peptide (ANP) mRNA, was significantly higher in the atrial muscle compared to other tissues. For mRNAs for the Ito channels, Kv …
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Funktionelle Analyse von MHC-Klasse-I-Genen der Rhesusaffen (<i>Macaca mulatta</i>)
… Killerzell-Immunglobulin-ähnliche Rezeptoren (KIR) auf NK-Zellen. Für den Rhesusaffen gelang in dieser Arbeit erstmals der experimentelle Nachweis einer spezifischen Interaktion zwischen Mamu-A- und KIR-Molekülen in einem in vitro-Modell. Die Ergebnisse der vorliegenden Arbeit implizieren, dass …
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