Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"KCNQ"”.
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Charakterisierung von KCNQ-Kaliumkanälen und ihren Beta-Untereinheiten
… Arbeit war die Charakterisierung von KCNQ-Kaliumkanälen und ihren beta-Untereinheiten. Im ersten Teil wurde die Expression von KCNQ1 und den beta-Untereinheiten KCNE2 und KCNE3 im Gastrointestinaltrakt mit Immunfluoreszenz und in situ Hybridisierung untersucht. Der zweite Teil der …
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Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm
… the therapeutic options are limited.</p><p>Kv7 (KCNQ) potassium channels are reported to be critical determinants of resting membrane voltage in several excitable cells including neurons and vascular myocytes. Recent findings from our laboratory suggested that arginine8-vasopressin exerts its …
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Explorando los canales de potasio KCNQ : una perspectiva en trastornos del neurodesarrollo y cardíacos
Los canales KCNQ son canales de potasio activados por voltaje, cuya función principal es regular la excitabilidad de neuronas y fibras musculares cardíacas. En neuronas, generan la corriente M (IM), que eleva el umbral para la generación de potenciales de acción, limitando su sobreactividad. …
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Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
… and involves activation of KCa3.1 and KCNQ potassium channels. Both KCa3.1 and KCNQ channels bind calmodulin (CaM) as a calcium sensor, with an additional role proposed for the protein hippocalcin. We measured the calcium sensitivity of the IsAHP and potassium channel associations with …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
… develop PAH. Both 5-HT and linopirdine, a KCNQ K+ channel inhibitor, were found to induce contraction of IPA, but were more potent in IPA from WT mice than 5-HTT+ mice. The 5-HT induced vasoconstriction was found to involve influx of Ca2+ from the extracellular space, Ca2+ release from the …
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Investigating novel therapeutic targets for treatment of visceral pain.
… In contrast subsequent pre-treatment with the KCNQ channel opener retigabine inhibited the colonic afferent response to ATP, bradykinin and ramp distension. Furthermore, in a separate set of experiments application of NS 1619 and SKA 31 abolished ongoing peristaltic activity demonstrating the …
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A novel postsynaptic location for Kv7 channels and their role in memory and nanoparticle advancement for dementia therapeutics
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01