Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"KAINATE"”.
-
ROLE OF LIPOCALIN 2 IN KAINATE-INDUCED NEURODEGENERATION
… present study investigates the role of LCN2 in kainate (KA)-induced neurodegeneration. Intracerebroventricular injection of KA in rats induces neuronal loss in the hippocampal formation. Therefore, the KA model was used as a neurodegeneration model to elucidate the role of LCN2 in …
-
Cellular mechanisms that modulate kainate receptor trafficking and assembly
Kainate receptors (KARs) in the mammalian brain play a variety of physiological roles that require selective assembly, intracellular trafficking, and synaptic targeting. Cytoplasmic and non-cytoplasmic determinants that modulate KAR expression at the plasma membrane have been recently …
-
The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
<p>Though the GluK4 kainate receptor subunit shows limited homology and a restricted expression pattern relative to other kainate receptor subunits, its ablation results in distinct behavioral and molecular phenotypes. To study the function of GluK4, I generated a global GluK4 knockout mouse line …
-
Investigations of The Structure-Function Relationship In Kainate Receptors Using FöRster Resonance Energy Transfer
<p>Kainate receptors belong to the family of ion channels known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory synaptic transmission, modulate the release of presynaptic glutamate, and facilitate dendrite formation. Kainate receptors are …
-
The roles of indoeamine-2,3-dioxygenase 1 and 2 during TMEV- and kainate-induced ictogenesis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
-
A structure-function analysis of the marine toxin neodysiherbaine and its synthetic analogs on kainate receptors
Kainate receptor antagonists show efficacy in multiple animal models of neuropathologies, including pain and epilepsy. These receptors are selectively targeted by a number of natural and synthetic ligands. The goals of this project were to identify compounds with unique specificity for kainate …
-
The Extracellular Domains of the AMPA, Kainate, and Orphan Delta Receptor Regulate Channel Gating in Distinct Ways
… propionic acid (AMPA) and kainate receptor mediate their function through fast glutamate-gated ionotropic activity, which needs precise structural changes to perform properly. While Cryo-EM structures have provided snap shots of these proteins, questions remain regarding the …
-
Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology
… pathophysiology and treatment. Here the role of kainate receptors, a member of the ionotropic glutamate receptors subfamily, was investigated in relaying sensory information upon activation of the trigeminovascular system. In order to study the role of kainate receptors on the periphery, we used …
-
Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
… regulatory proteins (IRPs), and ferritin in the kainate lesioned hippocampus.A sustained, upregulation of IRP1, IRP2, DMT1 and -IRE DMT1 protein was detected in astrocytes in the kainate lesioned hippocampus. An increase in ferritin expression, and increased level of ferric iron and ferrous iron …
-
B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… production. In the CNS, signaling through the kainate receptor (KAR) by glutamate causes an increase in ADAM10 expression. Human B cells were found to express a GluK2 containing kainate receptor and its activation increased ADAM10 expression which is in agreement with KAR activation in the CNS. …
-
Hippocampal output to neocortex: Examination of the electrophysiological and plastic properties of CA1 projections to the perirhinal cortex
… and that LTP-induction may require AMPA/kainate receptor activation but not NMDA receptor activation; indicating that glutamatergic signalling underlies synaptic plasticity in this projection. We also determine the role of the CA1 to perirhinal cortex projection in a model of …
-
Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
… ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, iGluRs are implicated in various neurological disorders, such as depression, schizophrenia, Alzheimer’s and …
-
Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… the ZIP8 transporter, (ii) the GluK1-containing kainate receptors, and (iii) the α5-containing nicotinic acetylcholine receptors (nAChR). First, we describe disturbances in baseline behavior and increased volitional alcohol intake in animals lacking the ZIP8 transporter. We then report the …
-
The synthesis and pharmacology of some novel excitatory amino acid analogues
… as N-methyl-D-aspartate (A1), quisqualate (A2), kainate (A3) and 2-amino, 4-phosphono butyric acid (A4); the designations in brackets being that of the nomenclature of Fagg and Foster.
-
Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
… consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct physiological role. In the recent years, significant progress has been made in understanding the biophysical, and functional properties of iGluRs. The development of Cryo-EM and X-Ray …
-
Conformational Changes In The Extracellular Domain of Glutamate Receptors
… cells. While crystal structures of AMPA and kainate subtypes of glutamate receptors have provided valuable information regarding the assembly and mechanism of activation; little is known about the NMDA receptors. Even the basic question of receptor assembly still remains unanswered. …
-
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
… Retikulum und im Golgi-Apparat zurückgehalten. Kainate, NMDA und GABA-A Rezeptoren erreichen die postsynaptische Membran ebenfalls nicht. Allerdings ist sowohl die Gesamtexpression von prä- und postsynaptischen Proteinen, deren Reifung, die Oberflächenexpression von weiteren Membranproteinen, …
-
ΙΔΙΟΤΗΤΕΣ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ L-ΑΣΠΑΡΤΙΚΟΥ ΚΑΙ ΚΑΙΝΙΚΟΥ ΟΞΕΟΣ ΕΓΚΕΦΑΛΟΥ ΠΤΗΝΩΝ. "ΣΥΜΒΟΛΗ ΣΤΗΝ ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ ΟΞΕΟΣ"
… ONTOGENY OF L-GLUTAMATE, L-ASPARTATE AND KAINATE BINDING SITES HAVE BEEN STUDIED IN MEMBRANE PREPARATIONS OF CHICK BRAIN. ONE BINDING COMPONENT WAS FOUND FOR L-[3H]GLUTAMATE AND L-[3H] ASPARTATE WITH A KD VALUE OF 176 NM AND 204 RESPECTIVELY. FOR KAINIC ACID TWO BINDING COMPONENTS WERE …
-
The role of apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosis
… produced apoptotic cell death, II) AMPA and kainate induced apoptotic or non apoptotic cell death depending on the experimental conditions utilized, III) EPO selectively protected motor neurons committed to dye apoptically.<br></br><br></br> In wobbler mice I found that: I) mitochondrial …
-
Role of the Neurotransmitter Glutamate in Neural Stem and Progenitor Cells Differentiation into Oligodendrocytes
… in co-cultures of OPCs with DRG neurons, AMPA/kainate inhibitors such as CNQX and DNQX, were tested. Although MBP positive cells were still identified in cultures treated with AMPA inhibitors, in the case of CNQX, the myelin sheath organization appeared distorted compared to the nontreated …
Page 1 of 2