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Showing 1 to 20 of 39 for “"Iron Acquisition"”.
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Roles for multiple iron acquisition systems in Vibrio cholerae
… is a highly successful human pathogen and environmental organism. To thrive in these diverse environments, it must encode the tools necessary to acquire essential nutrients such as iron. A number of V. cholerae iron acquisition systems have been identified, and altogether are necessary for …
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Role of entF Gene in Iron Acquisition by Brucella abortus 2308
… in domestic animals and wild life. For the acquisition of iron in mammalian hosts, species of Brucella are known to produce two siderophores, 2, 3-dihydroxy benzoic acid (2, 3-DHBA) and brucebactin. Inability to synthesize of 2, 3-DHBA affects the ability of pathogen to metabolize …
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Haem and xenosiderophore mediated iron acquisition by sinorhizobium meliloti and pseudomonas aeruginosa
… cell membrane is the principal barrier for the acquisition of essential nutrients such as iron. Although critical to the survival of bacteria, iron is extremely limited in the environment due to the formation of insoluble hydroxides at physiological pH. To surmount these obstacles bacteria have …
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Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition
Iron is an essential nutrient for the bacterium Staphylococcus aureus. Wild-type S. aureus utilizes various iron acquisition systems to support growth in iron deplete conditions. S. aureus small colony variants (SCVs) are associated with chronic infections, yet the mechanisms by which these …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
… has evolved a repertoire of high-affinity iron acquisition systems to facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy-harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB-dependent transporters (TdTs). The …
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Iron Acquisition in <em>Rhodococcus erythropolis</em> Strain IGTS8: Characterization of a Mutant Strain that Over Produces Siderophore.
<p>Iron is an essential nutrient for most bacteria because enzymes like nitrate reductase and cytochromes use it as a cofactor. However, in most aerobic, neutral pH environments, iron is essentially insoluble and not easily available for bacteria to use. Many bacteria respond to this problem by …
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Iron Acquisition in <em>Rhodococcus erythrolpolis</em>: the Isolation of Mutant(s) that Do Not Produce a Siderophore.
… basic physiology, genetics, and especially the acquisition of essential nutrients like iron, must be understood.</p> <p><em>R. erythropolis</em> strain IGTS8 releases a small compound called a siderophore, that scavenges ferric iron from the environment. To learn more about the genetic control …
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Iron Acquisition in <em>Rhodococcus erythropolis</em> Strain IGTS8: Characterization of a Mutant that Does Not Produce a Siderophore.
… how this poorly characterized bacterium acquires iron. N5-59 cells were starved for iron and then lysed to release any intracellular siderophore. No intracellular siderophore was detected indicating that N5-59 is not defective in the export or release of siderophore but is probably unable to …
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Characterization of Complex Transcriptional Regulation Within the YQJH-YQJI Intergenic Region
<p>Iron is an essential cofactor for many biological processes. Due to the potential toxicity of iron as a result of Fenton chemistry, iron homeostasis in humans and other mammals is tightly controlled; this leaves only minute amounts of free iron available to invading pathogenic bacteria. This …
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Investigation of a novel iron-uptake system and other genomic features in mecC Staphylococcus aureus
… lineages. For microbes and humans alike, iron is an essential cofactor in many biochemical reactions and S. aureus requires iron for colonisation and subsequent pathogenesis. The success of S. aureus is partly attributed to its ability to exploit the host iron pool. It does this through …
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Characterization of Fe-S Cluster Assembly On the Sufbc2D Complex
<p>In vivo biogenesis of iron-sulfur (Fe-S) cluster cofactors requires complex biosynthetic machinery to limit release of iron and sulfide, to protect the Fe-S cluster from oxidation, and to target the Fe-S cluster to the correct apo-enzyme. The SufABCDSE pathway for Fe-S cluster assembly in E. …
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The Impact of Iron Deficiency on Plant-Oomycete Interactions
… adapted to cope with dynamic changes in their environment. Abiotic stresses, such as heat, drought, or nutrient deficiency must be overcome simultaneously with biotic threats such as pathogens and herbivores. Oomycete pathogens represent a significant threat to global food production and natural …
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Nutrient availability modulating physiology and pathogenicity of <i>Legionella pneumophila</i>
… established in continuous culture under defined iron-replete conditions at pH 6.9. Iron-limitation and extremes of pH (6.0 and 7.8) influenced the growth and metabolism of <i>L. pneumophila</i>, as manifested by increased metabolic activity, impaired energy coupling, and altered metabolic fluxes. …
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Iron and the ecology of marine microbes
Iron is a cofactor of a number biochemical reactions that are essential for life. In the marine environment, this micronutrient is a scarce resource that limits processes of global importance such as photosynthesis and nitrogen fixation. Given that marine microorganisms play a central role in …
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Generation of <i>Mycobacterium smegmatis</i> Model Systems for Testing Inhibitors of the Mycobactin Siderophore of <i>Mycobacterium tuberculosis</i>
… against this pathogen. Biosynthesis of iron scavenging molecules, known as siderophores (e.g., mycobactin and carboxymycobactin), has been identified as a potential drug target candidate since iron acquisition has been directly linked to the survival and virulence of <em>Mtb</em>. …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… as other invasive fungal infections, are poor. Iron has been shown to be essential for Aspergillus fumigatus virulence. Furthermore, mechanisms in the iron regulatory network are believed to be potential drug targets since iron management in fungi is vastly different from that in mammals and …
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The development of a new reporter system to study the interaction between FbpA and FbpBC
Bacteria require efficient iron acquisition systems to infect and colonize the mammalian host. Neisseriaceae and Pasteurellaceae have developed an iron uptake system that involves iron removal from host glycoproteins. The human pathogen, Haemophilus influenzae, has a surface receptor complex …
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Transferrin binding protein B structure, function, and export in Neisseria gonorrhoeae
Iron, an essential nutrient for most microorganisms, is sequestered in the host by iron-binding proteins, such as lactoferrin and transferrin. Neisseria gonorrhoeae utilizes transferrin as an iron source and its iron acquisition system is composed of two transferrin binding proteins: TbpA and TbpB. …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica Upwelling Dome
… cycling in the ocean. It is estimated that iron is a limiting nutrient for phytoplankton growth in over 30% of the open ocean, but still little is known about bacterial strategies for iron acquisition. Siderophore (Fe ligand) production by bacteria may play a major role in influencing the …
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