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Showing 1 to 20 of 401 for “"In vitro model"”.
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In vitro model of periodontal epithelium
To develop a model for junctional epithelium, porcine periodontal ligament epithelial cells (PLE cells) were cultured from the epithelial rests of Malassez. The obtained epithelial cell lines were grown on a porous membrane that allows a good cell adhesion and access of the nutrients from both …
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Developing a 3D in vitro Model by Microfluidics
<p><em>In vitro</em> tissue models play an important role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D <em>in vitro</em> models allow the cells to grow and interact with their …
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Antioxidant properties of flaxseed lignans using in vitro model systems
The major objectives of this study were to investigate the antioxidant properties of flaxseed lignans secoisolariciresinol (SECO 2) and secoisolariciresinol diglycoside (SDG 1) and their major oxidative compounds using 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH 47) in an in vitro model of …
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Development of an in vitro model of contraction by fibroblasts
Dermal scars in adult humans are mechanically and functionally inferior to normal skin and can be physically disfiguring. The contraction of the wound by fibroblasts has been linked to the formation of scar. The mechanical and chemical signals, which control the contraction, are being investigated …
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Developing a Functional in Vitro Model of the Neuromuscular Interface
… neuromuscular system is responsible for the coordination of movement throughout the body, and while research has revealed many of the mechanisms involved in the function of the neuromuscular system, there are still many gaps in our understanding of how all of the components of the system work and …
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Optimization of an in vitro model to study Duchenne Muscular Dystrophy
… Muscular Dystrophy (DMD) is the most common inherited muscle disease, affecting 1 out of 5000 male live births. DMD pathology results from genetic and biochemical defects in the dystrophin-glycoprotein complex causing membrane instability, and accordingly, muscle fragility, apoptosis and …
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role of pentazocine in an in vitro model of hypoxia/reoxygenation
Experimental research is making considerable efforts to understand the rules that regulate the balance between toxic and protective brain innate immunity. Sigma-1 receptor is expressed in both neurons and glia is a unique class of intracellular proteins and is involved in neurodegeneration. Our aim …
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In vitro model development for novel prevention measures against foodborne pathogens
… applications and targeted approaches to investigating phenomena that drive the presence and absence of pathogens in our foods. The use of suboptimal methodologies for these investigations remains a hurdle to furthering preventative capabilities in many food and health systems. My …
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An in vitro model of human yolk sac and epiblast crosstalk
Embryogenesis entails complex signalling interactions between embryonic and extraembryonic lineages. Improved embryo culture techniques have recently allowed human embryos to be cultured in vitro past the point at which they would implant in vivo, until the internationally accepted culture limit of …
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The development of an in vitro model of coronary lesion thrombosis
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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TOWARDS AN IN VITRO MODEL FOR RNA INTERFERENCE- MEDIATED SUPPRESSION OF S100A8
The SI00 calcium-binding protein A8 (S100A8) has been identified as a potential genetic modifier of the lung disease of cystic fibrosis (CF) patients as well as mice. S100A8 and its heterodimeric partner, S100A9, are expressed by neutrophils and monocytes and secreted to the extracellular milieu …
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THREE DIMENSIONAL IN VITRO MODEL OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Head and neck squamous cell carcinomas (HNSCC) are among the leading causes of cancer related deaths throughout the world. The survival rate for this type of cancer is extremely low and has not changed significantly in recent decades. There is an imperative need to study tumor progression in a …
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Creation and validation of an enhanced in vitro model of the lungs
The increasing prominence of pulmonary drug delivery for local and systemic treatments coupled with the complex lung structure and the numerous factors affecting the pulmonary delivery of drugs has necessitated extensive research on this drug delivery route. The research mostly includes studies on …
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An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam.
The principle aim of this study was to derive an in vitro model that could be used to study corneal endothelial development. This was done by investigating methods to induce a mesenchymal-to-epithelial transition (MET) in mouse periocular mesenchyme cells to drive them to form fully differentiated …
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An oxygen-controlled in vitro model of the gastrointestinal human-microbiome interface
The gastrointestinal system plays a vital role in the functioning of the human body, processing food into useable energy, controlling homeostasis, and serving as the front line of the immune system. The intestines are aided in their many functions by the gut microbiome, a collection of 100 trillion …
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
… is a ligand-modulated transcription factor belonging to the nuclear receptor superfamily. PPARγ regulates genes involved in adipocyte differentiation, insulin homeostasis, neuroprotection and anti-inflammation. As such, PPARγ is under consideration as therapy for ischemic stroke, Alzheimer's …
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Developing an a-synuclein in vitro model for therapeutic testing for Parkinson's disease
Parkinson's disease (PD) is a slowly progressive neurodegenerative condition affecting various regions of the central nervous system, including the brainstem, basal ganglia, and cerebral cortex. Genetic links between α-synuclein and PD, coupled with the identification of aggregated α-synuclein in …
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A 3D in vitro model of the human gut-microbiome. A bioelectronics approach.
… human gut microbiota has emerged as a key player in the bidirectional communication of the gut-brain axis, affecting various aspects of health and disease. Although a vast array of studies have revealed the specific role of gut microbiota in various physiological and pathophysiological conditions, …
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The development and application of an in vitro model of coronary lesion thrombosis
Thrombosis is an initiating response to vascular injury. Physiologically, this process aids in the repair and remodeling of the vessel wall. However, if left unchecked, luminal occlusion may rapidly occur. The coronary vascular bed is a life-sustaining environment in which pathological thrombosis …
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