Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Immune memory"”.
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Immune memory and activation markers in systemic lupus erythematosus
… (SLE) is a chronic inflammatory autoimmune disease characterized by the loss of tolerance to self-antigens, immune complex deposition, tissue inflammation and destruction. SLE manifestations, prevalence and severity vary among different populations and ethnicities. Even today, the …
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Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
… remain unresolved clinical challenges due to immune dysregulation. Innate immune cells, particularly monocytes, are key regulators of inflammation and its resolution. However, unbalanced or prolonged stimulation can drive these cells into dysfunctional states. These cells may enter …
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Towards unravelling the immunomodulatory mechanisms of S. mansoni & L. major parasites in a mouse model using transgenesis
… immunomodulatory strategies to evade the host’s immune response and little is known about the mechanisms by which these two parasites modulate host immune responses. As a result, these parasites develop different subversion mechanisms to escape host immunity and controlling such immunomodulatory …
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Monitoring immune dynamics following infection and vaccination using B cell receptor sequencing
… of the genetic diversity underlying adaptive immune responses in health and disease. In the context of infectious diseases this can act as a powerful tool for identification of pathogen-specific immune signatures and genetic determinants of immune memory, protection and response to …
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Mathematical and Numerical Investigation of Immune System Development and Function
… to provide hypotheses on the mechanisms of immune response formation and function. The immune system, comprised of the innate and adaptive immune responses, is responsible for protecting the body against invading pathogens, with disease or vaccine induced immune memory leading to fast …
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INTERNALIZATION AND IMMUNOGENICITY OF MUCOSALLY-ADMINISTERED SOLUBLE AND PARTICULATE ANTIGENS
… virus; however, they do not induce mucosal immune responses, which are critical for protection against mucosal pathogens. The development of mucosal vaccines has had limited success thus far, due to several factors such as poor antigen uptake at the mucosal surfaces, lack of immunogenicity …
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Καλλιέργεια λεμφοκυττάρων ευαισθητοποιημένων στον εχινόκοκκο ατόμων παρουσία προϊόντων υδατιδικής κύστεως: Βλαστική μεταμόρφωση λεμφοκυττάρων και δράση επί των σκωληκοκεφαλών
… purpose of this work was: (1) to investigate the immune memory of lymphocytes from subjects with active or cured echinococcosis, and (2) to determine whether or not sensitized lymphocytes can kill E. granulosus scolices in vitro. Monocytes, mainly lymphocytes, were isolated by the Ficoll-Hypaque …
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Dysregulated TFH cell and germinal center activation in mice with severe Orientia tsutsugamushi infection
… pathogenesis and the observation of “poor immune memory” known to be associated with scrub typhus.
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Defining mRNA-generated T cell memory in respiratory viral infection
T cell immune memory provides protective effector mechanisms to restrict pathogen growth upon secondary infection, although the ability of T cells generated by novel mRNA-LNP vaccines to restrict viral infection in currently unknown. To address this, we studied antigen specific T cell memory …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… strategies to regulate their host’s immune response, to prevent expulsion and establish chronic infections. Understanding how they achieve this offers a therapeutic strategy for the treatment of human diseases which are caused by unregulated inflammation. Previous characterisation of …
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Smac Mimetic and Combination Immunotherapy for the Treatment of Urothelial Cell Carcinoma
… carcinoma (MB49) resistant to prominent immune-stimulating therapies BCG mycobacterium and PD-1/PD-L1 checkpoint blockade. I found treatment with a monovalent SM, LCL161, generated T lymphocyte-dependent cures of MB49, retaining potent anti-tumour immune memory and significantly improving …
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Interplay between Extra-Germinal Center expansion of memory B cells and affinity maturation during the humoral recall response
… the SARS-CoV-2 pandemic. Vaccines prime the immune system to mount tailored responses against antigens, like pathogen-derived proteins. However, some viruses can evolve to evade these immune responses. Targeting the regions of viral proteins that are conserved during such evolution is a goal …
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Investigating the Effect of Antibody-Mediated Feedback on Ongoing Germinal Center Responses
… such, the goal of most vaccinations is to induce immune memory in the form of long-lasting, high-affinity serum antibody titers, which requires the participation of B cells in the germinal center (GC) response. It is well-established that pre-existing antibodies can influence the outcome of future …
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Effect of Systemic Versus Localized Bacillus Calmette-Guérin Immunotherapy on Bladder Cancer Progression: Novel Role for Trained Immunity
… effect of BCG is incomplete. The tumor immune microenvironment (TiME) is known to influence responses to immunotherapy, and there is mounting evidence that the activation of a systemic immune response is critical for the induction of local anti-tumour responses. Based on this knowledge, …
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The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza Infection
… factors alter the functionality of cell-mediated immune memory. We identified distinct phenotypic changes in influenza-specific T cells from older subjects, which were predictive of their antibody responses upon influenza vaccination. However, the inactivated vaccine itself had no discernible …
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
Cancer immunotherapy, such as immune checkpoint inhibitors, Chimeric Antigen Receptor (CAR) T therapy, and cytokine therapy, have achieved successful improvement in extending survival in some patients. However, the immunosuppressive environment of solid tumors substantially compromises therapeutic …
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The Immunology of Adeno-Associated Virus Serotype 2
… gene therapy vector. Antibody and cell-mediated immune responses to AAV-2 or AAV-2 transfected cells may confound the therapeutic use of such vectors in the clinic. In this study, cell-mediated and humoral immune responses to AAV-2 were characterised from a panel of healthy blood donors. The …
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Nasal Associated Lymphoid Tissue in health, infection and autoimmunity
The immune system exists in three core components - epithelial surface barrier immunity to prevent entry of foreign antigens from the environment; innate immunity to provide an immediate but non-specific cellular immune defence response to foreign antigens; and an adaptive immune response providing …
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Antibody-Mediated Modulation of Polyclonal Immune Responses
… defense are sequentially activated: the innate immune response and the adaptive immune response. The innate immune response is the first line of defense, and consists mainly of myeloid cells that are quickly activated within hours to days to engage in a non-specific manner. This broad response …
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Animal models for investigating coronavirus heterotypic immunity
… have been made in understanding SARS-CoV-2, the immune response to endemic CoVs remains poorly understood. While most studies of immune memory are focused on defense against a subsequent infection with the same pathogen, this memory can cross-react with related pathogens in a phenomenon termed …
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