Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Immune Rejection"”.
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… antibody drug daclizumab to prevent the graft rejection. However, despite the administration of immunosuppressive drugs and the recent improvement in islet isolation, preparation and transplantation, insulin independence is rarely sustained for long term after islet transplantation. It was …
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Long-term expansion, genomic stability, in vivo safety and immunogenicity of adult human pancreas organoids
… this project utilises recently established human immune system (HIS) mice to interrogate in vivo hPO immune rejection under autologous and allogeneic conditions. Lastly, preliminary experiments show that hPOs can be genetically manipulated to express GFP and Luciferase which can be used for in …
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Experimental Study of Advanced Cryopreservation Strategies for the Cardiovascular System: Superiority of Vitrification over Standard slow Freezing in Murine Vessels and Efficacy of Ultrafast Rewarming by High-Intensity focused Ultrasound (HIFU) in Cardiac Recovery from Deep Hypothermia (-6ºC)
… cardiovascular grafts are highly susceptible to immune rejection. Currently, cold storage at 0–4 ºC is the gold standard for sample preservation, yet it maintains viability for only a few hours in hearts and a few days in vessels. Beyond this period, ischemic and structural damage severely …
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Eliminating oxygen supply limitations for transplanted microencapsulated islets in the treatment of type 1 diabetes
… partial protection of transplanted islets from immune rejection. However, the microcapsule prevents islet revascularization and creates an additional mass transfer resistance for oxygen transport to islets. This reduced oxygen transfer can lead to a hypoxic core within the islet that results in …
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The effect of Stromal cell Derived Factor-1 (SDF-1) and collagen-GAG (Glycosaminoglycan) scaffold on skin wound healing
… patient's bone marrow. Additional risks include immune rejection concerns, limited shelf-life and stringent storage requirements. To meet this need, a stem cell-attractant and inflammatory cell-repellant chemokine, Stromal cell Derived Factor-1 (SDF-1) was incorporated into a highly porous …
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Neuronal Differentiation and Functional Recovery after Transplantation of Human Mesenchymal Stem Cell in The Ischemic Rat Model
… patient have the advantage to minimize the immune rejection. In this study, cytokine-inducted human mesenchymal stem cells were transplanted via tail vein into cerebral ischemic rat model exposed to transient MCA occlusion. We examined that cytokine-inducted human mesenchymal stem cells …
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Design, Processing, and Characterization of Nanocomposites
… implants that typically come with a high risk of immune rejection. In this dissertation, a novel processing technique to fabricate porous poly(ether ether ketone) (PEEK) is developed and studied for its potential application as a bone replacement material. A PEEK composite was created with the …
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Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
… rate of over 90%. This low incidence of graft rejection is largely due to the unique properties of the eye that decrease the likelihood of mounting an immune response, a phenomenon called "immune privilege". Despite this characteristic, immune rejection remains the leading cause of corneal …
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Tissue engineering the anterior cruciate ligament : a regenerative medicine approach in orthopaedic surgery
… problems, such as donor-site morbidity and immune rejection. Furthermore, in younger patients these grafts fail to grow, leading to additional complications and underlining the need for the development of new approaches that improve the healing and repair of ligaments and tendons. This …
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… the eye from inflammatory damage, referred to as immune privilege. The mechanisms that protect the eye from inflammation-induced injury are 1.) the presence of immunosuppressive molecules within the aqueous humor; 2.) the expression of pro-apoptotic factors on corneal cells ; and 3.) the induction …
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Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb
… of metastases. The main emphasis was on the immune response after RIT, since it has been shown that radiation can lead to reprogramming of tolerogenic immune cells to become immunogenic (promote rejection of the tumor cells). Several studies have shown that tumors can reprogram the immune …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… with ethical issues and carry the risk of immune rejection and tumorigenicity. Direct conversion of patient’s own skin cells to neurons could overcome these problems and potentially restore function after transplantation in stroke-damaged brain. In this thesis we have used transgenic …
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Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
… cell availability, donor site trauma, possible immune rejection and potential tumorigenesis. Tissue regeneration by cell homing is a novel concept and may offer the advantage of accelerated clinical translation. Promising results have been shown using a cell homing approach to engineer a number …
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Development of Jetting Techniques for the Delivery of Mesenchymal Stromal Cells for Therapeutic Applications
… with this catheter can eliminate issues with immune rejection caused by scaffolds, or issues with the scaffolds themselves (mentioned above). Delivering specific number of MSC and/or other cell types directly to a specific tissue injury site, using the modified commercially available …
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Evaluation of Non-functionalized Single Walled Carbon Nanotubes Composites for Bone Tissue Engineering
… also limited by the risk of disease transfer and immune rejection. To circumvent these limitations tissue engineering has evolved as a means to develop viable bone grafts. An ideal bone graft should be both osteoconductive and osteoinductive, biomechanically strong, minimally antigenic, and …