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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Immediate release"”.
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Improvement of Release Criteria for Immediate Release Solid Oral Dosage Forms
… the statistical power of USP compendial release tests and recommended alternatives.</p><p> The U.S. drug supply chain, formerly protected by a closed distribution network, is now threatened by the legal and illegal importation of drug products. Whereas quality can never be inspected into …
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Predictive Disintegration Process Modelling of Immediate Release Tablets Using Terahertz Technology
… during scale-up. Predicting disintegration for immediate-release tablets remains challenging due to the process complexity. This research addresses this by establishing a predictive and mechanistic framework based on terahertz (THz) characterisation and physics-informed modelling. This model …
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The design and manufacture of immediate-release optimal solid dosage forms
… produce the most common pharmaceutical products, immediate-release solid dosage forms, from drug substance and excipient are: blending, wet granulating, drying, milling and screening, blending, tableting, coating, and so on. A new process, such as blending combined with solvent-less, …
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Immediate release ginseng chewable tablets and sustained release amino acid pellets based on dry powder coating technology platform
… technology platform, this study aimed to develop immediate release ginseng chewable tablets using the electrostatic powder coating technique and sustained release amino acid pellets using the plasticizer powder coating technique. For the immediate release ginseng chewable tablets, the content and …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
Bioavailability and clinical effectiveness of a poorly soluble drug can be highly affected by its formulation design. In this respect, research on solid dispersion of hydrophilic carrier has commenced a decade ago to resolve the problem of poorly soluble drug. However, the availability of solid …
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Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product
… The model drug product for this work was an immediate release carbamazepine tablet. Carbamazepine was selected as the model active pharmaceutical ingredient because it has a narrow therapeutic index and is designated as a class II compound (i.e. high permeability, low solubility) according to …
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Estimating intragastric disintegration times of immediate release dose units administered after a high-calorie, high-fat meal using standardized, commercially available equipment and materials
Στόχος της παρούσας εργασίας ήταν η διερεύνηση της χρησιμότητας τυποποιημένου, εμπορικά διαθέσιμου εξοπλισμού και υλικών στην εκτίμηση των ενδογαστρικών χρόνων αποσάθρωσης δοσολογιών μονάδων προϊόντων άμεσης αποδέσμευσης μετά από τη χορήγηση γεύματος υψηλής θερμιδικής αξίας και υψηλής …
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Preparation and Characterization of Spray Dried Fluorescent Micro particles for Controlled Release in the Lungs.
… showed that showed that the powders showed an immediate release of the dyes that is within a period of 10-15 minutes and the two polymers fail to show a controlled release of the dyes that is typically reported to be over a period of several hours in the literature. Hence only a part of the …
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Theoretical prediction of drug release in GI tract from spherical matrix systems
The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is …
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Investigating the Hydration and Disintegration Mechanisms of Film-Coated Pharmaceutical Tablets
… of hydration, disintegration and subsequent drug release and dissolution of a film-coated tablet are not fundamentally understood. To investigate the mechanisms, flat-faced tablets with a diameter of 13 mm and a thickness between 1.5 mm and 1.6 mm were directly compressed, and an immediate release …
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Evaluating the relationship between motor symptoms and Levodopa dosage in Parkinson’s disease
… Daily Dosage (LEDD), measured with daily Sinemet immediate-release dosages. The intent of this study was to find commonalities between patients to provide more concrete progression and treatment guidelines. From this comparison, it was learned that no direct measurable relationship could be found …
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Batch foaming of hot melt extruded excipient/disintegrant/API pharmaceutical formulations and the study of the effects of the resulting cellular structures on API dissolution
… impact of a disintegrant included in a foamed immediate release system composed of a polymer excipient and an Active Pharmaceutical Ingredient (API). Indomethacin (INM) is used as model API; Eudragit EPO (EPO) is used as polymer excipient; AcDiSol and Crospovidone (Cros) are used as two kinds …
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Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… drug products with high quality and versatile release. First, we present a method to encapsulate functional nanoemulsions in alginate capsules for more versatile delivery of lipophilic active ingredients. The nanoemulsions are intrinsically viscous, ensuring the formation of spherical capsules …
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Activation of Release by Hydration in Pharmaceutical Tablets Studied by Terahertz Pulsed Imaging
… tablets that do not disintegrate (e.g. sustained release tablets), hydration of the oral solid dosage form still plays a critical role in activating the drug release. In this thesis, terahertz pulsed imaging (TPI) was used to investigate the hydration kinetics of pharmaceutical tablets in a …
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Pharmaceutical formulation development utilizing hot melt extrusion and other techniques for development of immediate and controlled release dosage forms
… a processing technology for the manufacture of immediate as well as controlled release formulations for oral delivery of two model compounds. For immediate release applications lower molecular weight grades of Hydroxypropyl cellulose polymers, EF and ELF, were utilized as carrier matrices to …
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Liposome-loaded biosynthetic bacterial cellulose hydrogels for wound management applications
… liposomes have the advantage of controlling drug release thus reducing toxic side effects, in addition to protecting drugs from degradation and clearance. In this study, liposomes were produced via the reverse-phase evaporation (REV) method. The antimicrobial activity of liposomal silver nitrate …
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IN VITRO IN VIVO METHODS AND PHARMACOKINETIC MODELS FOR SUBCUTANEOUSLY ADMINISTERED PEPTIDE DRUG PRODUCTS
… (IVIVC) for subcutaneously administered immediate release (IR) peptide based drugs in a biorelevant manner. The contribution of IVIVC in drug development of orally administered drugs is very well known. For oral drugs, the in vivo process of drug absorption is often rate limited by the …
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The Effects of Minimum Size Limit Regulations On Exploited Fish Populations off the Atlantic Coast of the Southeastern United States
… sublegal-size bycatch of co-occurring species, release mortality for undersize fish, and differential size-selective mortality that removes faster growing fish. Effects of size limits were investigated utilizing catches from a commercial fisherman and an individual-based model. The entire catch …
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Development and manufacture of novel amorphous Itraconazole drug products using quality by design principles
… of ITZ. A novel strategy for the compaction of immediate release tablets of ITZ-KOL-ASDs using inorganic salts (sodium chloride, potassium chloride, potassium dihydrogen orthophosphate, potassium bromide, and potassium bicarbonate) was investigated. ASD tablets compacted with potassium chloride …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… in the formulation of oro-dispersible and fast immediate release tablets.
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