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Showing 1 to 20 of 34 for “"Igf2"”.
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Untersuchung des transkriptionellen Mechanismus der Igf2- Überexpression in Patched-assoziierten Tumoren
… paternalen Überexpression des Wachstumsfaktors Igf2 untersucht.Die detaillierte Analyse der Promotoraktivität des Igf2-Gens in RMS zeigte, dass die aberrante Überexpression von drei Transkripten (T1, T2 und T3) auf die Aktivierung von drei Promotoren (P1, P2 und P3) zurückzuführen ist. In die …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
The autocrine-paracrine effects of IGF2 are important in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and …
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Oct4 and Sox2 regulate methylation at the Igf2/H19 imprinting control region
Mono-allelic expression of H19 and Igf2 depends on parental-specific methylation of an imprinting control region (ICR). Although CTCF sites maintain the absence of DNA methylation on maternal ICRs after fertilization, some Beckwith-Wiedemann patients showed maternal ICR methylation that correlated …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
… zone (Jz). Insulin like growth factor 2 (Igf2) is a growth-promoting paternally expressed imprinted gene found in an imprinting locus with H19, a maternally expressed imprinted long noncoding RNA. In mice, manipulation of the expression of these genes or the differentially methylated …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… memory decline. Insulin-like growth factor 2 (Igf2) is a genomic imprinted gene that is important in development, and remains highly expressed within the brain, specifically in neurons. Administration of IGF2 to the hippocampus of aged animals has been shown to improve memory, and decreased …
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Comparison of the molecular phenotypes of pigs carrying different IGF2 alleles at four developmental time points
… polymorphism in insulin-like growth factor 2 (IGF2 intron3-G3072A) is associated with greater muscle mass and decreased subcutaneous fat deposition in pigs carrying a paternal copy of the A allele (Apat). While many studies have focused on the differences in between the gross phenotypes of …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… interest, the insulin-like growth factor 2 (IGF2), overexpressed in the majority of ACC, is a growth factor responsible for the autocrine proliferative loop that sustains ACC growth. In the IGF2 system, two well addressed tyrosine-kinase receptors, IGF1R and IR, were found responsible for the …
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Regulation of skeletal muscle growth and gene expression by insulin-like growth factors and myostatin
Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that is thought to primarily promote prenatal skeletal muscle growth. A SNP within intron 3 of IGF2 identified as IGF2-intron3-G3072A has a considerable impact on lean yield as a result of increased postnatal IGF2 …
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Creation and characterization of mice with a mutation disrupting binding of a transcriptional repressor of insulin-like growth factor 2
Insulin-like growth factor-2 (IGF2) is a key regulator of myogenesis as it promotes differentiation of myoblasts during embryonic and fetal development. A single nucleotide polymorphism (SNP) identified in pigs in intron 3 of IGF2 disrupts a binding site for the transcriptional repressor ZBED6 …
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Comparative analysis of the porcine IGF2-G3072A mutation and reduced myostatin function on meat quality and unexplained mortality in pigs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Tissue- specific DNA methylation profiles in newborns
… study was to assess DNA methylation profiles of IGF2 DMR and H19 in DNA derived from four tissues of the newborn. We obtained from 6 newborns DNA from fetal placental tissue (n = 5), umbilical cord CD34+ hematopoietic stem cells (HSC) and CD34- mononuclear cells (MNC) (n = 6), and umbilical cord …
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The regulation of post-natal growth in sheep through the growth hormone - insulin-like growth factor axis
… were used to measure receptors for GH, IGF1 and IGF2 in skeletal muscle of prepubertal lambs which had undergone treatment with exogenous growth factors and/or degrees of nutritional restriction before slaughter. Plasma concentrations of IGF1 were positively correlated with good nutrition and …
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Establishment of a phenotypical model of adverse outcomes associated with assisted reproductive technologies
… on chromosome 11p15.5, namely the KvDMR1 and H19/IGF2. There is a similar overgrowth phenotype that is observed in ruminants as a result of embryo culture. This syndrome is known as large offspring syndrome (LOS). The genomic region/s associated with LOS have not yet been determined. We …
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RUOLO DELL'ISOFORMA A DEL RECETTORE INSULINICO E DEL SUO PARTNER MOLECOLARE DDR1 NEL CANCRO AL SENO
… ligandi, insulina e il fattore di crescita 2 (IGF2), nelle cellule umane di cancro mammario. A tale scopo abbiamo generato delle cellule di cancro mammario umane MCF7 iperesprimenti IGF2. Inoltre abbiamo studiato l’effetto metabolico dell'IR-A infettando stabilmente le cellule MCF7 prive di …
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Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
… imprinted gene insulin-like growth factor 2 (Igf2) encoding a major placental and fetal growth factor. IGF2 is also a known mitogen for hepatocytes and several hematopoietic lineages. Thus, IGF2 is a potential inducer of Ascl1-dependent phenotypes including placental overgrowth and maternal …
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Imprinted Gene Expression and Phenotype of Bovine Concepti with Bos taurus and Bos indicus Genetics
… transcripts and splice variants of the imprinted IGF2 and IGF2R genes as well as their imprinted regulatory non-coding RNAs, H19 and AIRN, (ii) to analyse expression patterns of all identified transcripts in bovine pre- and postnatal tissues, and (iii) to investigate fetal genetic effects on gene …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… (TGFß, HGF, FGF2, FGF7, PDGFA, PDGFB, VEGFA y IGF2), citoquinas inflamatorias (IL6 y IL8), quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs con dos líneas celulares de cáncer de mama …
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Anotación de nuevos microRNAs en el genoma porcino mediante una aproximación basada en Machine Learning
… hsa-miR-483, alojado en el intrón 2 del gen IGF2, cuya función estaría ligada a la regulación de la proliferación celular y la diferenciación de adipocitos, influyendo en la capacidad de integración y depósito de lípidos en respuesta a variaciones en la ingesta de alimentos. Estos resultados …
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
… 1 beta (IL1Β), and insulin-like growth factor 2 (IGF2) were elucidated as genes that were significantly expressed in GD12 placenta. These genes are similar in that they are all connected to the Jak-Stat signaling pathway. These findings provide a possible mechanism for birth defect reduction by …
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The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… disrupted the imprinting of the H19-Igf2 locus in the mouse placental endocrine zone (junctional zone, Jz; maternally inherited Jz-ICR1). This is because this locus is important in controlling the formation and function of placental endocrine cells. Thus, the aims of this study were …
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