Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"IVT"”.
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Design, Off-Target Toxicity, and Intracellular Processing of Nucleotide-Modified Messenger RNAs for Human Therapies
… therapy, in which in vitro-transcribed mRNA (IVT mRNA) is introduced to cells for therapeutic applications. IVT mRNA is transfected into target cells, translated, and the fully-synthesised encoded protein exerts a therapeutic effect via specific mechanisms. IVT mRNAs have been applied to …
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Atmospheric Rivers Effects on Severe Convective Storm Environments from 1979 to 2023
… with a base Integrated Vapor Transport, IVT, criteria of IVT ≥ 500 kg m-1 s-1 . AR presence was compared against the region's top 30 SCSE days for six perils (tornado, significant tornado, hail, significant hail, wind, significant wind). Results indicate that broader, less restrictive …
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Extended transient transfection by repeated delivery of in vitro-transcribed RNA
… stability and translation efficiency of the ivT RNA were quantified. Transcripts were delivered to cells by electroporation, and a method of increasing the rate at which cells recover from ivT-RNA transfection by combined knockdown of innate-immune-related genes was developed. Using this …
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The Distracted Driver: Modeling the Impact of Information Bandwidth, in -Vehicle Task Priority, and Spatial -Separation on Driver Performance and Attention Allocation
The introduction of new in-vehicle technologies (IVTs) and telematics into the automobile creates additional tasks that drivers may perform while driving. To the extent that these devices interfere with driving performance there will be concerns for safety. In three experiments, we explored how …
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Superconductivity and low temperature properties of niobium diselenide single crystals grown by direct vapor transport
… prepared by the DVT and iodine vapor transport (IVT) procedures. These measurements indicated the niobium on the surface of the IVT samples was more completely oxidized than the niobium on the surface of the DVT samples, whereas, XPS spectra of cleaved DVT and IVT surfaces were similar. In both …
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Influence of tidal volume on pulmonary gas exchange during general anaesthesia
… without PEEP to 10 cmH2O or with increased VT (IVT) achieved by increasing inspired plateau pressure 0.04 cm H2O kg-1. Extra apparatus dead space was added to maintain PETCO2 at 4.5 kPa. Arterial oxygenation, sevoflurane tension (Pasevo, Fisevo, PETsevo), PaCO2, PETCO2, stroke volume, cardiac …
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Longer term neurocognitive outcomes after acquired brain injury
… have focused on the effect of thrombolysis (IVT) and thrombectomy (EVT) on survival and functional outcomes. Little is known about the cognitive outcomes after IVT and EVT following acute ischemic stroke. The objective of this systematic review was to determine the differential cognitive and …
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Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
… immune response to in vitro transcribed (IVT) mRNA and elevate the expression of the encoded gene, to examine the interaction between pseudouridine and inosine modifications. While A-to-I editing activity is required for endogenous RNA to evade the innate immune response, our results show …
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Development of a Novel Cam-based Infinitely Variable Transmission
An infinitely variable transmission (IVT) is a transmission that can smoothly and continuously vary the speed ratio between an input and output from zero to some other positive or negative ratio; they are a subset of continuously variable transmissions (CVTs), which themselves do not have the …
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Exploring Student Perspectives of Interactive Virtual Tours in an Agricultural Education Context
… logistical concerns. Interactive virtual tours (IVT) are a type of virtual tour that integrate a variety of content delivery methods and curriculum pieces to make the virtual tour mirror an actual tour as closely as possible. In the current study, undergraduate students’ perceptions of an IVT of …
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Engineering therapeutic messenger RNA for triple-negative breast cancer
… a plasmid vector for in vitro transcription (IVT) of a truncated variant of HER2 (TrHER2), lacking the intracellular domain (ICD) to eliminate the potential for proliferative signalling. Modified nucleosides were incorporated into IVT reactions and mRNA was enzymatically capped and poly(A) …
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Trashing old notions: the significance of small tRNAs in Trichomonas vaginalis extracellular vesicles and implications for host-parasite communication
… were more inhibitory to in vitro translation (IVT) than TOG3 (GGG) and TOG5 (GGGGG), and tRFs were more inhibitory than tRNA halves. However, some fragments were inhibitory independently of their 5’ sequence, suggesting something other than their 5’end interferes with translation. The analysis …
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Multi-scale features of atmospheric rivers and the linkages with local-scale hydrological impacts on the U.S. West Coast
… the vertically integrated water vapor transport (IVT). AWB-ARs impinge in a more westerly direction on the coast while CWB-ARs impinge in a more southwesterly direction. Most of the landfalling ARs along the northwestern coast of the U.S. (states of Washington and Oregon) are AWB-ARs, due to their …
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Effect of Heavy Lifting with a Head Strap on the Pelvic Floor across the Menstrual Cycle
… strap. Using intravaginal pressure transducers (IVT), the mean change in intraabdominal pressure (IAP) was found to be 37.1(4.3) cmH20 when lifting a load with a mean weight of 19.8(3.2)kg using a head strap. Lifting tasks were simulated with isometric ballistic lifts against a head strap secured …
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The Influence of the North Atlantic Subtropical High on Atmospheric Rivers Over the Eastern United States
… ERA5 derived integrated water vapor transport (IVT) > 500 m-1 s-1 with lengths > 2000 km. Composites of thresholded 850 hPa heights, AR-concurrent PRISM precipitation, AR spatial frequency distribution maps, and seasonal AR frequency histograms per node illustrate seasonal interactions between …
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Nematomi insulto simptomai /
… Mild stroke is usually excluded from the IVT treatment protocol due to the potential benign prognosis and the potential risk of bleeding, although some of these patients may have poor outcomes. There are also 'invisible' stroke symptoms after stroke - those that are not detected by the …
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Analysis of Variability in Atmospheric River Characteristics in New Zealand from 1940 through 2023
… 95th percentiles of integrated vapor transport (IVT) to isolate moderate and extreme ARs and assess their sensitivity across the three periods. Mann-Kendall tests were produced to analyze trends in AR strength and size across the three periods, while Mann-Whitney U tests compared AR strength …
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Electrical Characterization of Gallium Nitride Drift Layers and Schottky Diodes
Interest in wide bandgap semiconductors such as silicon carbide (SiC), gallium nitride (GaN), gallium oxide (Ga 2 O 3 ) and diamond has increased due to their ability to deliver high power, high switching frequency and low loss electronic devices for power conversion applications. To meet these …