Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"IME4"”.
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Localization and Mutational Analysis of the Nuclear and Aggregation-Prone Ime4 Protein in Saccharomyces cerevisiae
<p>In <em>Saccharomyces cerevisiae, </em>Ime4 is a protein that is induced during meiosis and has a primary role in regulating sporulation in starving diploids. One function of Ime4 is methylation of adenosine residues within mRNA transcripts. Recent studies have shown Ime4 to be induced in …
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Effects of a putative Reb1 protein binding site on IME4 sense and antisense transcription and sporulation in Saccharomyces cerevisiae
… are an important part of the life cycle and IME4 gene expression is required for these processes. IME4 sense transcript levels of expression are influenced by the level of its complementary non-coding antisense strand by mechanisms that are currently unknown. The a1-alpha2 heterodimer binding …
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ARCHITECTURE AND RNA RECOGNITION BY THE EUKARYOTIC M6A METHYLTRANSFERASE COMPLEX
… of five subunits conserved across eukaryotes: Ime4, Kar4, Mum2, Vir1, and Slz1 (homologous to human METTL3, METTL14, WTAP, VIRMA, and ZC3H13). Using an integrative structural biology centred on cryo-electron microscopy, the organisation and stoichiometry of the ycMTC were elucidated. The 2.6 Å …
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Regulation of yeast development by mRNA methylation
… in the third chapter of this thesis. We identify Ime4, Mum2 and Slz1 as the components of a protein complex that catalyzes mRNA methylation in yeast. These components are necessary for m⁶A accumulation during nutrient starvation; mutation of any one of these components results in defects in …