Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"IL10"”.
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Methylsulfonylmethane and anti-IL10 antibody: Novel feed additives for supporting poultry health
… additives, methylsulfonylmethane (MSM) and anti-IL10 antibody contained in a dried egg product (DEP), in improving immunity and antioxidant capacity of birds during oxidative stress and coccidiosis. Methylsulfonylmethane is an organic, sulfur-containing compound that has demonstrated …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse develops intestinal inflammation with similar characteristics to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is the study of small molecule metabolites, involving the …
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The Role of Bacterial Amyloids In Regulating Gastrointestinal Homeostasis
… cytokines such as Interleukin 10 (IL10) from subepithelial lamina propria cells. IL10 has been shown to contribute to the maintenance of the intestinal epithelial barrier and IL10-deficient mice develop lethal colitis within the first 2-3 months of life. 6-8 week-old female C57BL/6 …
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Regulatory T cells and circulating cytokines : novel prognostic markers in squamous cells carcinoma of the head & neck
… In this thesis, the circulating levels of serum IL10, IL12 and Treg cell levels in PBMC were determined and their association with clinical outcome in HNSCC patients were investigated.Serum cytokine levels were determined by ELISA in patients pre-treatment (n=107), 4-6 weeks post-treatment (n=43) …
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Phänotypische und funktionelle Charakterisierung von CD4+CD25+ "regulatorischen" T-Zellen aus dem Nabelschnurblut
… 24h abgezogen und die Zytokine IFN-g, TGF-ß, IL10 und IL13 mittels ELISA gemessen. <br>Ergebnisse: Die CD4+CD25+ T-Zellen stellten einen mittleren Anteil von 4,6% der CBMC dar (Range 1,7-7,7).Sie zeigten nur eine geringe Proliferationsantwort auf Stimulation mit IL2 (Median SI 1,8) im …
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Modifying the lung microenvironment through gene delivery of immunomodulatory cytokines
… delivering Interleukin 2 (IL2), Interleukin 10 (IL10), and Interleukin-1 receptor antagonist (IL1ra) to the lung and evaluated their impact on respiratory disease models including acute lung injuries caused by influenza and lipopolysaccharides (LPS), as well as chronic lung diseases like COPD. …
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Μελέτη προφλεγμονωδών και αντιφλεγμονωδών κυτταροκινών σε ασθενείς με ισχαιμικό αγγειακό εγκεφαλικό επεισόδιο
… γονίδια φλεγμονωδών κυτταροκινών (IL4-589C>T, IL10-1082G>A, TNFa-308G>A, IL6-174G>C και IL12B 1188A>C) σε 145 διαδοχικούς ασθενείς με οξύ Ι-ΑΕΕ και ισάριθμους μάρτυρες. Επιπρόσθετα, η μελέτη αξιολόγησε το ρόλο της αντιφλεγμονώδους κυτταροκίνης αντιπονεκτίνης στην οξεία φάση του Ι-ΑΕΕ, καθώς και …
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Immungenetische Marker im Wandel der Zeit
… polymorphisms (SNP) der Interleukine IL6, IL10 und IL4 sowie der Rezeptoren IL4Ra, TLR2 und TLR4 untersucht. Ihre immungenetische Relevanz ist für moderne Bevölkerungen bereits durch Assoziationsstudien belegt. Zentraler Gegenstand der Studie war die Untersuchung eines historischen …
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Apoptotic Cells, Anti-Phospholipid Antibodies, and Anti-Chromatin Antibodies in Autoimmunity
… tested suppressed IL12, TNFa, while increasing IL10 production from macrophages. Further studies with various anti-Fc?R antibodies implied the essential role of various Fc?Rs in elevation of IL10 by auto-ICs. Studies with Mer-/- macrophages indicated that Mer is also crucial in auto-IC mediated …
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Einfluss atopischer Prädisposition auf allergenspezifische Proliferation und Zytokinprofile maternaler und fetaler mononukleärer Blutzellen
… mittels ELISA bestimmt wurden: IL4, IL5, IL10, IL13, IFNg. ERGEBNISSE: Angegeben werden jeweils die positiven Proliferationsantworten in Prozent (SI > 2) und der Stimulationsindex (SI): IL2: M 100 (21), N 100 (26); BLG: M 98 (14), N 92 (17); OVA: M 36 (2), N 31 (2); Derp: M 32 (2), N 17 …
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Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
… </strong>exosomes induced expression of IL10, TGFB2, and CCL22 mRNA (markers of M2 macrophages) and decreased phagocytosis, efferocytosis, and macrophage-mediated tumor cell killing. In contrast, exosomes from non-metastatic<em> </em>K7 or Dunn cells did not inhibit phagocytosis, …
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Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
… high levels of the anti-inflammatory cytokine IL10. This effect was dependent on P38 MAPK pathway activation and phosphorylation of the transcription factor CREB. Similar results were seen with proteasome inhibitor Bortezomib which is used clinically in the treatment of multiple myeloma. This …
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The gut microbiome: A key regulator of mucosal tolerance, barrier function, and vaccine response
… to the gut microbiota, focusing on the role of IL10 in regulating immune responses to resident microbial antigens. Immunization with whole-cell lysates (WCL) derived from ASF bacteria reveals genotype- and IL10-dependent differences in immune responses. In IL10-deficient mice, a broader range of …
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Characterization of Host Immune Responses to Eimeria adenoeides Infection in Turkey Poults
… expression of cytokines (CXCLi2, IL1β, IFNγ, IL10, and IL13) was observed in the ceca following infection. In experiment 3 (Chapter IV), we attempted to model the field situation by investigating the acquisition of immunity under conditions poults could encounter following placement upon …
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Investigating the potential utilisation of black soldier fly (Hermetia illucens) as an alternative protein source in tilapia and carp feed
… A, slc6a18, and cytokines (il1β, tnfα, il10) in either the intestine or head kidney were not significantly affected, but slc15a1a was upregulated at 40% BSF meal compared with the control.<br/>Similar results were obtained in juvenile mirror carp fed the same BSF meal at 20% and 40% over …
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p,p' DDE Regulated Gene Expression and Possible Mechanisms of Action in Breast Tumor
… (tgfb1) and downregulation of interleukin 10 (il10) in splenic leukocytes indicated that localized delivery of p,p' DDE to the mammary gland also influences systemic immune responses. Significant upregulation of il10 by p,p' DDE and hydroxyflutamide suggest that some of p,p' DDE actions may be …
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Exploring neuro-immune interactions in neurodegeneration: the role of B lymphocytes in Parkinson’s disease
… to matched controls. A higher proportion of IL10 producing regulatory B lymphocytes was associated with better outcomes. Alpha synuclein transgenic mice also had reduced circulating B lymphocytes. Mice with a genetically driven B lymphocyte deficiency developed a worse motor phenotype and …
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Construction of comparative and framework linkage maps for the identification of quantitative trait loci in cattle
… ACADM, AMY1 and TSHB mapped to BTA3, and AT3, IL10, MYOG and PGD mapped to BTA16. Additionally, bovine NPPA mapped to BTA16 using somatic cell hybrid analysis. Comparison of the bovine genetic maps to humans and the mouse reveals both similarities and differences between the species.
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Immunomodulation of commercial line and Piau Brazilian Naturalized breed pigs in response to vaccination against Mycoplasma hyopneumoniae and Pasteurella multocida type D
… os genes TLR2, TLR4, TLR6, TLR10, IL2, IL6, IL8, IL10, IL12, IL13 e TNFα entre os tempos estudados, após duas doses da vacina; enquanto os animais Piau tiveram somente diferença de expressão para a citocina antiinflamatória TGFβ. Para expressão gênica em células de BALF dos animais comerciais …
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