Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"IKB"”.
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Brain Inflammation Regulated by PINK1
… activation levels of STAT3 and Akt, and enhanced IkB degradation. STAT3 has been known to inhibit IkB degradation, and I found that an Akt inhibitor, LY294002, increased the expression of pro-inflammatory cytokines. These results suggest that PINK1 deficiency enhances the expression of …
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Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells
… sequential events for NF-kB activation, that is, IkB-α phosphorylation, p65 translocation into nucleus and NF-kB transcriptional activity. TLR4 conveys LPS-signal to intracellular compartment via MyD88- and TRIF-dependentpathways,whichculminateintheactivationofNF-kB. As well as, IBC attenuated …
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Signal Specific Ubiquitination and Degradation of IkBa
… in the cytoplasm by the action of its inhibitor IkB. Upon phosphorylation by the IKK complex, IkB is rapidly ubiquitinated and targeted for 26S proteasome mediated degradation, thus liberating NF-kB for transport to its nuclear destination. The current project was initiated to reconstitute this …
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Muscle catabolism in cancer and its attenuation by eicosapentaenic acid
… the degradation of the NFKB inhibitor protein IKB. When an NFKB inhibitor was added to C2C12 myotubes, prior to the addition of PIF, proteasome activity and protein degradation was inhibited, showing that NFKB is responsible for the increased proteasome activity and muscle catabolism induced by …
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Roles of NF-kB in spinal cord injury pathophysiology
… and sustained protein level decreases in IkB family members, IkB-a and Bcl-3, suggesting early and prolonged activation of NF-kB up to 28 days after SCI. Validation of NF-kB activation was performed by immunohistochemical analyses of spinal cord cross sections and Western blot assay …
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… protein kinase C alpha/beta increases IKK and IkB phosphorylation, cyclin D1 expression and increased S-phase fractions. Immunohistochemical staining for NF-kB, IkB and cyclin D1 increased in the high pressure center of human tumors and decreased toward the periphery. </p> <p> Finally, I …
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An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer
… NF-kB activity, with a stabilisation of IkB\(\alpha\) following CLU overexpression in C666-1. Although sCLU is now considered a promising therapeutic target because of its anti-apoptotic function, with an antisense oligonucleotide currently undergoing clinical evaluation, results suggest …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
… the NF-kB-pathway by a dominant negative IkB vector could not restore glucocorticoid receptor action disturbed by IL-1b. Conclusions: Our data suggest that proinflammatory cytokines may influence the effect of corticosteroids in intestinal epithelial cells. The quantity of glucocorticoid …
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
… and 2.083 ± .6712 vs. 2.895 ± .8444, p<0.05 for IKB-α and HSP70, respectively). Plasma endotoxin was higher compared to pre-exercise at the 2hr post-exercise in the PLA trial (2.883 ± 0.4310 pg.ml vs. 4.550 ± 0.3350 pg.ml, p<0.05 respectively) and significantly higher when compared to the 2hr …
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Contribution to the elucidation of the anti-inflammatory activity of Sesquiterpene Lactones
… to inhibit p65 binding. The amount of remaining IkB-a is too low to explain the observed NF-kB inhibition. No inhibition of the IKK was observed in an assay performed with immunoprecipitated kinase. Four different SLs were used in these experiments, and led to identical results, confirming that …
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Cis and Trans, p53 and NF-kB rules of transactivation
… was examined. Further, the negative modulator IkB-alpha was co-expressed and its impact measured as a function of NF-kB protein type, expression level, or RE being tested. Both for p53 and NF-kB studies, we confirmed that the hierarchical organization of nucleotides within REs observed with …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… EDARADD. Moreover, mutations in TRAF6, NEMO, IKB and NF-kBs genes are responsible for Immunodeficiency associated EDA (EDA-ID). Several molecules, as SHH, WNT/DKK, BMP and LTβ, have already been reported to be EDA pathway regulators or effectors although the knowledge of the full spectrum of …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
… (ERK1-2), c-Jun N-terminal kinase, p38 MAPK, and IkB kinases (IKKs) (41,42,43). Here, we report SRC-3 to be a nucleocytoplasmic shuttling protein, whose cellular localization is regulated by phosphorylation and interaction with ERalpha. Using a combination of high throughput and fluorescence …
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Characterization of Cytotoxicity against Cancer Cells induced by Human Monoclonal Antibody Specific to TRAIL-R1
… lines, JNK-dominant negative (DN), c-JUN-DN, IkB-DN Jurkat cell lines. PI3K inhibitor WM was also used. To investigate the effect of calcium on DR4-4 Fab-induced cell death, Jurkat cells were pretreated with BAPTA/AM (intracellular Ca++ chelator) before treatment of DR4-4 Fab. To determine …
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Isolierung und Strukturaufklärung terpenoider Inhaltsstoffe aus Montanoa hibiscifolia und Oyedaea verbesinoides sowie Untersuchungen ihrer biologischen Aktivität
… dass dieser Effekt auf eine Hemmung der IkB-Degradierung zurückzuführen ist. <br>8. In einem weiteren Kapitel wurde der Circulardichroismus vorgestellt und sein Einsatz bei der Strukturaufklärung von SLs vorgestellt.
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Three Essays in Empirical Asset Pricing
The financial crisis of 2007-2008 led to extraordinary government intervention in firms and markets. The scope and depth of government action rivaled that of the Great Depression. Many traded markets experienced dramatic declines in liquidity leading to the existence of conditions normally assumed …