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Showing 1 to 20 of 28 for “"IGFBP-3"”.

  1. Essais de purification de l'insulin-like growth factor binding protein-3 (IGFBP-3) bovine

    Colinet, FrédéricULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech2003

    … system, especially the somatotrope axis. IGFBP-3 is the major carrier of the IGFs (the main growth-promoting peptide) in plasma circulating as part of a 150 kDa ternary complex with one IGF peptide and a single acid-labile subunit. The IGFBP-3 purification would allow the measure of the …

    liege Repository record

  2. Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.

    Garza, Amanda2015

    … primary component of the IGF signaling involves IGFBP-3. It is well documented that IGFBP-3 levels are significantly increased in senescent human diploid fibroblasts however IGFBP-3 function is not known in this system. Interestingly, Werner syndrome fibroblasts, commonly used as a model of …

    vcu Repository record

  3. IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner

    Price, Deanna2021

    <p>Insulin-like growth factor binding protein-3 (IGFBP-3) belongs to a family of six IGF binding proteins. We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the …

    emich Repository record

  4. Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance

    Cassino, Theresa RachelVirginia Tech2002

    … IGF-I with the cell surface in the presence of IGFBP-3 which suggested increased association of IGF-I with IGFBP-3 at low pH. We studied cell free interaction of IGF-I and IGFBP-3 as a function of pH using surface plasmon resonance (SPR) in order to understand the mechanism that causes the …

    vt Repository record

  5. Characterization of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) interaction with the Bovine Aortic Endothelial (BAE) cell surface: Examination of the Role of Heparan Sulfate Proteoglycans (HSPG)

    Parghi, NiravVirginia Tech1998

    Insulin-like growth factor binding proteins (IGFBPs) are known to be important modulators of the insulin-like growth factor (IGF-I). However, their precise role is as yet unclear. Further, recent studies have indicated that IGFBP-3 has a receptor mediated growth inhibitory response of its own. In …

    vt Repository record

  6. Investigations of Insulin-Like Growth Factor I Cell Surface Binding: Regulation by Insulin-Like Growth Factor Binding Protein-3 and Heparan Sulfate Proteoglycan

    Balderson, Stephanie D.Virginia Tech1997

    … of insulin-like growth factor binding protein-3 (IGFBP-3), is influenced by heparan sulfate proteoglycans (HSPG). Initial research will be presented, assumptions and hypotheses that were included in the development of mathematical models will be discussed, and the future enhancements of the models …

    vt Repository record

  7. Nutritional Regulation of Serum Insulin-Like Growth Factor-I Concentration in Cattle

    Wu, MiaozongVirginia Tech2007

    … concentrations of IGF-I, IGF binding protein-3 (IGFBP-3) and acid-labile subunit (ALS), and their mRNA expression in the liver were determined in beef cows. It was found that increased nutritional intake did not alter basal concentrations of serum IGF-I, IGFBP-3 or ALS, or their mRNA expression …

    vt Repository record

  8. The Role of Insulin-like Growth Factor-I and IGF-binding Proteins in Mammary Gland Development

    Weber, Miriam S.Virginia Tech1998

    … factor-I (IGF-I) and IGF-binding proteins (IGFBP), the initial objective was to evaluate the physiological effects of recombinant IGF-I synthesis in the mouse mammary gland. Expression of recombinant IGF-I was targeted by the mouse mammary tumor virus - long terminal repeat (MMTV-LTR) to the …

    vt Repository record

  9. Roles of Zinc in Skeletal Muscle Cells Growth

    Zhang, XiangfengUniversity of Illinois at Urbana-Champaign2015

    … assay yielded affinities as follows IGF-1R > IGFBP-5 > IGF-2R > IGFBP-4 > IGFBP-2 &ap; IGFBP-3. The estimated Kd for zinc ranged from 27 nM to 340 nM. To test the hypothesis that zinc enhanced IGF activity through altering IGFBP binding to IGF, the effects of zinc on IGFBP-3 inhibition of …

    uiuc Repository record

  10. Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells

    Zhou, Yuehua

    … and are modulated by six IGF binding proteins (IGFBPs) which either inhibit or enhance IGF action. The effect of RA on the IGF system in HBCs has not yet been determined. Therefore, because RA inhibits and IGFs stimulate proliferation and differentiation, I tested the hypothesis that RA inhibits …

    loma-linda Repository record

  11. Microphysiometry Studies of Rapid Binding of Insulin-Like Growth Factor I by Parental and Transfected Mammary Epithelial Cell Lines

    Robinson, Rose MarieVirginia Tech1998

    … the effect of insulin-like binding protein-3 (IGFBP-3) both in the presence and absence of IGF-I, finding no IGF-I independent effect in the rapid binding experiment and no effect on stimulation of IGFBP-3 pre-incubated cells by subsequent IGF-I challenge. This is of particular interest due to …

    vt Repository record

  12. Isolation and functional analysis of differentially expressed genes in human prostate cancer

    Grzmil, Michal2012

    … IGF-IR Genexpression und der Hochregulierung von IGFBP-3 oder der Herunterregulierung der Expression von MMP-2 in androgen-unabhängigen PC-3 Zellen existiert. Zusätzlich wurden die Expressionen sowohl von IGF-IR als auch von IGFBP-3 mittels quantitativer real time RT-PCR an RNA aus …

    goettingen Repository record

  13. Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I

    Robinson, Rose MarieVirginia Tech2004

    … IGF-I and added IGF-I increased the amount of IGFBP-3 secreted by the cells into growth media. Additionally, it was hypothesized that the presence of collagen I, an important ECM protein, would alter the cell production of insulin-like binding protein-3 (IGFBP-3), a protein that modulates IGF-I …

    vt Repository record

  14. Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells

    Romagnolo, DonatoVirginia Tech1993

    … factor-I (IGF-I) and IGF-binding proteins (IGFBPs) genes in mammary epithelial cells. To test the hypothesis that IGF-I affects growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed expressing an ovine exon-2 containing …

    vt Repository record

  15. Funktionelle Analyse des Prostate-derived-Ets-Factors (PDEF) in der Prostatakarzinomzelllinie LNCaP

    Schulz, Karoline Anna2012

    … PCA3. Im Gegensatz zu diesen Genen war die IGFBP-3-Expression mehr als 2-fach hochreguliert. Die Herunterregulierung von PDEF macht eine Funktion des Gens in Tumorzellproliferation und Apoptose deutlich. Eine siRNA-vermittelte Abnahme der Zellproliferation ging mit entsprechender Expression …

    goettingen Repository record

  16. Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts

    Novosyadlyy, Ruslan2012

    … und sechs hochaffinen IGF-Bindungsproteinen (IGFBPs) ist an der Regulation von Metabolismus, Wachstums-, Differenzierungs- und Reparaturprozessen beteiligt und spielt möglicherweise eine wichtige Rolle für die Pathophysiologie der Leberfibrogenese. Das Hauptziel dieser Arbeit bestand daher …

    goettingen Repository record

  17. Composición de la microbiota en pacientes pediátricos con déficit de hormona de crecimiento antes y después de recibir tratamiento con hormona de crecimiento

    García Navas, PatriciaUniversidad de La Rioja (España)2025

    … growth factor transporter protein-3 (IGFBP-3) and poor growth, with decreased linear growth and body weight, suggesting that mammals require the gut microbiota to ensure optimal growth. In this regard, studies in preclinical animal models have shown that physiological levels of growth …

    dialnet Repository record

  18. Growth Factor and Extracellular Matrix Regulation of Heifer Mammary Development

    Berry, Sarah Dianne KnowlesVirginia Tech2002

    … cell proliferation, IGF-I protein increased and IGFBP-3 protein decreased within mammary tissues. Thus, proliferation was associated with an apparent net increase in the biological availability of IGF-I within the mammary gland. In the second experiment, decreased mammary development and …

    vt Repository record

  19. The Influence of Insulin-like Growth Factor Pathway Gene Polymorphisms on the Strength Training Response of Muscle Phenotypes in Older Adults

    Hand, Brian Dudley2006

    … insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in skeletal muscle. The -202 polymorphism in the promoter region of the IGFBP3 gene has been shown to influence IGFBP-3 levels. In addition, there have been reports that IGF-1 and …

    maryland Repository record

  20. The effect of freeze-dried whole blueberry powder on joint flexibility, mobility, and serum biomarkers of cartilage metabolism in symptomatic knee osteoarthritis

    Smith, AmyTexas Woman's University2019

    … IGF-1 with consistently stable concentrations of IGFBP-3, while the placebo group had declining concentrations of IGF-1 and increases in IGFBP-3 over the course of the study. The FDBP group had an overall decrease in concentrations of YKL-40 from baseline to the final evaluation, while the placebo …

    twu Repository record

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