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Showing 1 to 20 of 64 for “"IFN-g"”.

  1. Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity

    … estrogen may alter the levels and/or response to IFN-g, a prototype Th1 cytokine, that plays a pivotal role in immunity against intracellular infections and in many autoimmune and inflammatory disorders. We found that estrogen treatment tended to upregulate the secretion of IFN-g protein and mRNA …

    vt Repository record for Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity (opens in a new tab)

  2. The Role of Interferon Gamma in the Stroma of Growing and Regressing Tumours

    … der Rolle von Interferon gamma (IFNg) in der Abstoßung von Tumoren durch geringe Konzentrationen von Cyclophosphamide (Cy). Diese Arbeit zeigt, daß haematopoetische Zellen IFN-g produzieren, welches für die Abstoßung von Tumoren notwendig ist. Mit Hilfe des Cincinnati Zytokin …

    tu-berlin Repository record for The Role of Interferon Gamma in the Stroma of Growing and Regressing Tumours (opens in a new tab)

  3. Die Rolle von Interferon-g bei der Tumorabwehr von B16GP33-Lungenmetastasen durch CD8 T-Lymphozyten

    … Behandlung entschei-dend von der Interferon-g (IFN-g) -Synthese des tumortragenden Tieres abhängt. <br>Um die Rolle von IFN-g bei der Tumoreliminierung zu verstehen, wurden die Lungen von B16GP33-Metastasentragenden IFN-g defizienten und -kompetenten Mäusen nach dem adopti-ven Transfer von …

    freiburg-diss Repository record for Die Rolle von Interferon-g bei der Tumorabwehr von B16GP33-Lungenmetastasen durch CD8 T-Lymphozyten (opens in a new tab)

  4. DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1

    … STAT1 (p-STAT1) in response to interferon-gamma (IFN-g) compared to cells from wild-type (WT) mice. DJ-1 deficiency also attenuated IFN-g-induced interactions of SHP-1 with p-STAT1 and STAT1, measured 1 and 12 h after IFN-g treatment, respectively. Notably, DJ-1 bound to SHP-1 independently of …

    ajou Repository record for DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1 (opens in a new tab)

  5. Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis

    … the model of Th1-Th2 paradigm: gamma interferon (IFN-g)-secreting Th1 cells protect the host from developing progressive diseases, while interleukin (IL)-4-producing Th2 cells drive the disease pathogenesis. Focused on L. amazonensis infection in mice, this dissertation study is mainly intended to …

    utmb Repository record for Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis (opens in a new tab)

  6. Die Rolle des Interferon-g bei der Hemmung der Replikation des Hepatitis-C-Virus

    … vorangehenden Studien wurde nachgewiesen, daß IFN-g einen hemmenden Effekt auf die HCV-Replikation hat. Meine Experimente bestätigten die direkt antivirale Wirkung von IFN-g. <br>Mit Hilfe einer strangspezifischen Northernblotanalyse konnte gezeigt werden, daß der hemmende Einfluß des IFN-g, im …

    freiburg-diss Repository record for Die Rolle des Interferon-g bei der Hemmung der Replikation des Hepatitis-C-Virus (opens in a new tab)

  7. The Role of Interferon Gamma in the Regulation of IL-18 Binding Protein and the Development of Autoimmune Arthritis in a Genetically Non-Susceptible Mouse Strain

    … is unknown, but the role of cytokines, including IFN-g, as effectors of immune cell function has been established by the examination of cytokine production in RA patients and through the use of animal models. C57BL/6 (B6) mice that express MHC class II molecules of the b haplotype …

    tenn-hsc Repository record for The Role of Interferon Gamma in the Regulation of IL-18 Binding Protein and the Development of Autoimmune Arthritis in a Genetically Non-Susceptible Mouse Strain (opens in a new tab)

  8. Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity

    … local inflammation induced by the secretion of IFN-g. Using assays of single cell resolution, it was studied to what extent these two effector function of CD8+ cells are linked. Granzyme B (GzB) is stored in cytolytic granules of CD8+ cells and its secretion is induced by antigen recognition of …

    wurz-thes Repository record for Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity (opens in a new tab)

  9. Charakterisierung der allergischen Immunantwort : Vergleich der in-vitro Zytokinproduktion isolierter mononukleärer Zellen und der in-vitro Zytokinproduktion aus Vollblutproben bei Neonaten und Erwachsenen

    … wurden die Konzentrationen der Zytokine IFN-g, IL-10 und IL-13 mittels ELISA quantifiziert. <br>Bei den Neonaten wurden sowohl nach PHA -, als auch BLG-Stimulation signifikant niedrigere IFN-g (MC: PHA 588 pg/ml; BLG 819 pg/ml) - und IL-10-Werte (MC: PHA 485,7 pg/ml; BLG 163,4 pg/ml) …

    freiburg-diss Repository record for Charakterisierung der allergischen Immunantwort : Vergleich der in-vitro Zytokinproduktion isolierter mononukleärer Zellen und der in-vitro Zytokinproduktion aus Vollblutproben bei Neonaten und Erwachsenen (opens in a new tab)

  10. T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection

    … apparent lack of a negative regulatory effect of IFN-g/IFN-g-signaling on Th17 cells, which contradicted published reports. To clarify the role of IFN-g, we investigated the effect of IFN-g- or Stat-1-deficiency during T. cruzi infection. Surprisingly, IFN-g did not have a major role in …

    vcu Repository record for T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection (opens in a new tab)

  11. Untersuchung der Interleukin-5-Rezeptor-Expression und der Aktivierung humaner eosinophiler Granulozyten

    … sind es erhöhte Konzentrationen des TH1-Zytokins IFN-g, sowie des für die Reparatur des zerstörten Bronchialepithels benötigten TGF-ß1. <br> Im Rahmen dieser Arbeit konnte das Überleben und die Expression des Aktivierungsmarkers CD69 auf eosinophilen Granulozyten konzentrationsabhängig durch IL-3, …

    freiburg-diss Repository record for Untersuchung der Interleukin-5-Rezeptor-Expression und der Aktivierung humaner eosinophiler Granulozyten (opens in a new tab)

  12. Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection

    … many characteristics of IBD such as elevated IFN-g and microbiota-mediated inflammation, along with disappearance of Paneth cells. However, little is known about what happens to these Paneth cells and if their loss exacerbates inflammation. In this study, we have generated a number of …

    utswmed Repository record for Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection (opens in a new tab)

  13. Immunopathogenic mechanisms of non-healing cutaneous leishmaniasis caused by Leishmania amazonensis infection

    … of IL-10. The investigation of the role of IFN-g in L. amazonensis infection revealed that IFN-g alone could promote parasite growth within macrophages (MFs) by inducing the expression of mouse cationic amino acid transporter-2B (mCAT-2B), a key transporter for L-arginine. Although a clear …

    utmb Repository record for Immunopathogenic mechanisms of non-healing cutaneous leishmaniasis caused by Leishmania amazonensis infection (opens in a new tab)

  14. The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation

    … and indirect cytokine/chemokine production (e.g. IFN-g), which shapes the subsequent adaptive immune response. The importance of this role of NK cells in human health is highlighted by the recurrence of herpesvirus infections in NK-deficient patients, as well as a clinical association between low …

    wustl Repository record for The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation (opens in a new tab)

  15. Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis

    … life-threatening toxoplasmic encephalitis (TE). IFN-gamma-dependent, cell mediated immune responses play an essential role in preventing the reactivation of chronic infection of T. gondii in the brain. In my dissertation study, we examined the mechanisms of IFN-gamma-mediated prevention of TE by …

    vt Repository record for Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis (opens in a new tab)

  16. Untersuchung der Infizierbarkeit von Endothelzellen mit Masernviren und des Interferon-induzierten antiviral wirksamen Mechanismus

    … wurde beschrieben, dass das Typ II-Interferon (IFN-g) im Serum von Patienten mit akuten Masern und nach einer Masernimpfung erhöht ist (Okada et al., 2001; Ovsyannikova et al., 2003) und dieses Zytokin lässt sich auch in Gehirnläsionen von SSPE-Patienten detektieren (Nagano et al., 1994). …

    wurz-thes Repository record for Untersuchung der Infizierbarkeit von Endothelzellen mit Masernviren und des Interferon-induzierten antiviral wirksamen Mechanismus (opens in a new tab)

  17. Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes

    … die Expression der Sekretion der Zytokine TNF-a, IFN-g, GM-CSF, IL-5, IL-10, IL-13 und IL-15 gemessen. Dabei zeigte die Chorionkarzinomzelllinie JEG-3 eine Unterdrückung der TNF-a-, IFN-g-, GM-CSF- und IL-13-Produktion, aber eine Erhöhung der IL-10- und IL-15-Produktion gegenüber JAR. …

    wurz-thes Repository record for Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes (opens in a new tab)

  18. Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof

    … characterized by high interferon-gamma (IFN-g) production with no interleukin-4 (IL-4) secretion as well as high IgG2a and minimal IgG1 production. A colorimetric cytotoxic T lymphocytes (CTL) assay was developed to demonstrate that strain RB51 induced an antigen-specific CTL reaction …

    vt Repository record for Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof (opens in a new tab)

  19. Generation of Baculovirus-Brucella Abortus Heat Shock Protein Recombinants; Mice Immune Responses Against the Recombinants, and B. Abortus Superoxide Dismutase and L7/L12 Recombinant Proteins

    … Humoral (Western blot), cell mediated (CMI, IFN-g- release by splenocytes, and CD3+CD4+, CD3+CD8+ T cell/ total splenocytes ratios) and protective immune responses of BALB/c mice (challenge with virulent <i>B. abortus</i> 2308) against these recombinants, against <i>B. abortus</i> superoxide …

    vt Repository record for Generation of Baculovirus-Brucella Abortus Heat Shock Protein Recombinants; Mice Immune Responses Against the Recombinants, and B. Abortus Superoxide Dismutase and L7/L12 Recombinant Proteins (opens in a new tab)

  20. Phänotypische und funktionelle Charakterisierung von CD4+CD25+ "regulatorischen" T-Zellen aus dem Nabelschnurblut

    … wurden nach 24h abgezogen und die Zytokine IFN-g, TGF-ß, IL10 und IL13 mittels ELISA gemessen. <br>Ergebnisse: Die CD4+CD25+ T-Zellen stellten einen mittleren Anteil von 4,6% der CBMC dar (Range 1,7-7,7).Sie zeigten nur eine geringe Proliferationsantwort auf Stimulation mit IL2 (Median SI …

    freiburg-diss Repository record for Phänotypische und funktionelle Charakterisierung von CD4+CD25+ "regulatorischen" T-Zellen aus dem Nabelschnurblut (opens in a new tab)

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