Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Hypocretin"”.
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Effects of Chronic Sleep and Food Deprivation on In Vivo Levels of Prepro-Hypocretin (PPH)
The hypocretin peptides are two hypothalamic peptides known to be involved in both sleeping and feeding behavior, however their specific roles in these domains are not well understood. The present study sought to determine the effect of chronic (72-hour) sleep deprivation and (48-hour) food …
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Investigation of hypothalamic molecular mechanisms underlying narcolepsy and obesity through DNMT1 and leptin receptor signalling
… in humans, which preferentially affects the hypocretin neurons that regulate sleep, also induce neuronal loss when introduced into mice. No evidence was found for the loss of sleep-regulatory hypocretin neurons in Dnmt1 mutant mice. The second project used proximity proteomic methods to …
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Eating behaviours and attitudes in narcolepsy and their association with sleepiness and mood
… investigated possible reasons (other than hypocretin deficiency) for these findings. The aim was to investigate the eating behaviours and attitudes of individuals with narcolepsy. The sample consisted of 73 individuals with narcolepsy and 74 controls. Measures used were the Bulimia Test, …
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The Role of Orexin in Decision Making
… focuses on a subset of the hypothalamus: hypocretin/orexin producing neurons (HONs) for their role in driving decisions related to physical activity, feeding, and cognitive constraints on decision-making. The first part of this thesis will focus on how HONs multiplex metabolic and …
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Age-Related Alterations in Orexin Modulation of Septo-Hippocampal Neurotransmission
<p>Hypothalamic orexin/hypocretin neurons project widely to telencephalic regions influential in learning and memory, such as the hippocampus and the medial septum (MS) of the basal forebrain. Within the MS, orexin innervates cholinergic and GABAergic parvalbumin (PV) containing neurons that …
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Arc expression in the parabrachial nucleus following taste stimulation
… peptide 1 receptor RNA; 17 % co-expressed hypocretin receptor 1 RNA; 9 % co-expressed gastrin-releasing peptide RNA; and 20 % co-expressed neurotensin RNA. This co-expression with multiple different neuropeptides suggests that bitter-activated Arc expression mediates multiple neural …
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Investigating Central Chemoreception-based Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden Unexpected Death in Epilepsy (SUDEP) causes significant mortality in epilepsy, affecting 1:1000 people every year. Preceding SUDEP, patients experienced a final GTC seizure, transient apneas and bradycardia, culminating in terminal apnea and asystole. Failure to recover from postictal …