Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Hox"”.
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New roles for Hox and Wnt in Cell Migration
… new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron migration. To study migrating neurons I use the model organism nematode worm Caenorhabditis elegans. With only 302 neurons, C. elegans is an excellent model to examine migration of individual …
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Hox Targeting in Vertebrate Forelimb Induction: Expression and Comparative Genomics
<p><em>Hox</em> genes encode master regulators of body plan during embryonic development. In land and avian (bird) vertebrates there are four clusters of <em>Hox</em> genes (A, B, C, D). Patterns of <em>Hox</em> expression (paralogs 5-8), in our work specifically <em>Hoxc5, c6, c8,</em> and …
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Inhibition of Hox function by the cell cycle regulator geminin
… murine Geminin transient mit den Mitgliedern des Hox-repremierenden Polycomb-Komplexes in Abhängigkeit vom. Zellzyklus, mit dem Chromatin Hox-regulatorscher DNA-Elemente und mit Hox-Proteinen assoziiert. Funktionsgewinn und verlust Experimente im Hühnerneuralrohr haben gezeigt, dass Geminin die …
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Identification of Drosophila heart-specific Cis-Regulatory Modules under Hox control
… and functional differences controlled by Hox genes, key regulators of axial patterning. Overexpression and inactivation of the Hox gene abdominal-A (abd-A), which is expressed exclusively in the heart, revealed that abd-A controls heart identity. The aim of our work is to isolate the …
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Patterning of the posterior neurectoderm by labial-like Hox genes and retinoids
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
… Here, the link between histone modifications and Hoxb gene expression in mouse embryonic stem (ES) cells was explored. Levels of the “active” modifications H3K9ac and H3K4me3 at Hoxb promoters varied widely from gene to gene, but were closely correlated in ES cells. Contrastingly, the repressive …
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Genetic Analysis of Hox Transcription Factors and Cofactors in the Regulation of Programmed Cell Death in C Elegans
It has been well established that blocking apoptosis can promote cancer. Throughout the animal kingdom, apoptosis is exquisitely regulated in cell-specific and context-specific ways to ensure proper development and tissue homeostasis. In many cases, transcriptional pathways carry out this …
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CONTRIBUTIONS OF THE 3' HOX GENES, HOXA1, HOXB1, AND HOXB2, TO PATTERNING OF THE AXIAL SKELETON DURING DEVELOPMENT
To investigate whether Hoxb1, as well as related proteins Hoxa1 and Hoxb2, are involved in vertebral development, we analyzed the skeletons of 18.5dpc Hoxa1, Hoxb1, and Hoxb2 loss-of-function single and double mutant embryos. Our analysis reveals that loss of Hoxb1 and Hoxb2 function leads to …
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Análisis genómico y transcriptómico de los genes hox durante el desarrollo larvario del lenguado senegalés (solea senegalensis, kaup 1858)
… se ha demostrado la implicación de los genes hox en el desarrollo de sus estructuras anatómicas durante las primeras etapas de vida. Estos genes son clave en la diferenciación celular, la morfogénesis y la determinación del plan corporal. Por esta razón, en este trabajo se aplicaron técnicas …
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An evolutionary perspective on the sequence, mechanism, and regulatory function of animal microRNAs
… at three paralogous loci in the mammalian Hox clusters, and has complementarity to messages of several Hox genes, including Hox8 paralogues. RNA fragments diagnostic of miR-196-directed cleavage of Hoxb8 were detected in mouse embryos. Cell culture experiments demonstrated down-regulation …
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Development of leg motor neurons in drosophila melanogaster
… candidate gene approach. In vertebrate systems, Hox genes and Hox cofactors regulate spinal cord motor neuron identity. Although much work has been done addressing the function of Hox genes and Hox cofactors in vertebrate motor neuron development, the function of Hox genes and Hox cofactors in …
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Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction
… PBX1 is a major cofactor for most members of the HOX family of homeodomain proteins and is necessary for regulating the essential role that HOX proteins play in development and tissue homeostasis. We have identified an interaction between the E2A-encoded portion of E2A-PBX1 and the CREB-binding …
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
… of self-renewal. In hematopoietic cells, HOX genes are partially responsible for self-renewal, and HOX gene dysregulation commonly occurs in acute myeloid leukemia: AML). HOX dysregulation is seen in AML with translocations involving HOX genes themselves: e.g. NUP98-HOXA9) and with other …
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Eine Studie zur Segmentidentität des paraxialen Mesoderms bei Vogelembryonen : alle Zellen eines Somiten enthalten dieselben Informationen zur Segmentidentität
… Segmentidentität wird in den Somiten durch den Hox-Code festgelegt und führt zur segmentspezifischen Entwicklung der Wirbel. Es wird der Frage nachgegangen, ob alle Zellen eines epithelialen Somiten identische Informationen zur Segmentidentität besitzen. Dafür wurden an 2 Tage alten Embryonen …
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A novel computational method for inferring dynamic genetic regulatory trajectories
… In particular, the trajectories taken by the Hox genes through the space of regulatory states are characterized. Understanding the dynamics of Hox regulation is important because the Hox genes play a fundamental role in the establishment of motor neuron sub-type identity during development [6].
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Multi-scalar mechanisms timing axial progenitor contribution to the vertebrate body axis
… to the body axis centres around a changing Hox gene expression complement in the population (‘The Hox Clock’) that can influence the timing with which cells enter the body axis (Deschamps and Duboule, 2017; Iimura and Pourquie, 2006). In this thesis, I utilise classical experimental …
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Generation of A L. Hesperus embryonic cDNA library for the isolation of genes involved in early pattern formation
… primarily use two families of genes called Hox genes and Pax genes to regulate embryogenesis. Because of the high evolutionary conservation of Hox and Pax proteins, I hypothesize that arachnids also use this system to organize their body pattern. To enable studies of the Westem black widow …
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E2F6 in axial skeletal development and gliosis
… and participates in PcG-mediated repression of Hox genes. Hox genes are required for correct patterning of the mammalian skeleton. Loss of E2f6 results in posterior axial skeletal transformations. Mice deficient for both E2f6 and Bmil, a component of PRC1, exhibit increased penetrance of axial …
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