Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 435 for “"Hotspots"”.
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Moving hotspots
The assumption that stationary hotspots underlie the Earth’s lithospheric plates has been most important in the development of the theory of plate tectonics. According to the fixed hotspot hypothesis seamount trails are formed by volcanism penetrating the lithospheric plates whilst moving over …
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The Automatic Detection of Small Molecule Binding Hotspots on Proteins: Applying Hotspots to Structure-Based Drug Design
… that the method can differentiate between the hotspots, and the warm spots later used during fragment elaboration. For ligand-bound structures, they provide an intuitive visual guide within the binding site, directing medicinal chemists where to grow the molecule and alerting them to suboptimal …
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Avifauna and Anthropogenic Forest Disturbance in Two Biodiversity Hotspots.
… on avifaunal communities in two biodiversity hotspots- lowland tropical forest in the Lambusango Forest Reserve within the Wallacean archipelago and Neotropical cloud forest in Cusuco National Park, Mesoamerica. Both these study areas possess diverse bird communities with high rates of …
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Structural analysis of phosphorylation hotspots and kinase target preferences.
… phosphorylation, defined as phosphorylation hotspots, were determined us- ing phosphosite data for a total of 40 eukaryotic species. A total of 241 domain regions were identified as hotspots within 162 domain families that were then mapped to proteins structures. These regions were shown to …
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From Shadows to Hotspots: Imaging of Inner Protoplanetary Disc Structure
… imaging results provide tentative evidence for hotspots rotating at half-Keplerian velocities. This adds to growing evidence from similar studies that inner disc hotspots rotate at sub-Keplerian speeds, potentially indicating the influence of a companion. Finally, I present a pilot study using …
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Profiling hotspots of DNA breaks and learning-induced gene expression in the mouse brain
Neuronal activity generates DNA double-strand breaks (DSBs) in the brain. Topoisomerase IIb (TOP2B), important for relieving transcription-associated DNA supercoiling, was implicated as the source of these neuronal activity-induced DSBs, facilitating rapid transcriptional induction of immediate …
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Hotspots, Extinction Risk and Conservation Priorities of Greater Caribbean and Gulf of Mexico Marine Bony Shorefishes
… vetted during the Red List process indicate that hotspots of limited range endemics, which are species that may be more susceptible to extinction, are located in Venezuela, Belize and the northeastern Gulf of Mexico. Nearly a quarter of the Gulf endemics are threatened. The regional threat level …
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Mapping Plant Biodiversity Hotspots at the County Scale: A New Tool for Establishing Resource Conservation Strategies
… first identified the world’s 25 biodiversity hotspots and pioneered innovative ideas about the usefulness of biodiversity models for establishing long-term resource conservation strategies at global scales. Since Myers, most of the subsequent studies using hotspot science for biodiversity …
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Identifying Forest Conversion Hotspots in the Commonwealth of Virginia using Multitemporal Landsat Data and Known Change Indicators
This study examines the effectiveness of using the Normalized Difference Vegetation Index (NDVI) derived from 1326 different Landsat Thematic Mapper and Enhanced Thematic Mapper images in finding isolated housing starts within the Commonwealth of Virginia's forests. Individual NDVI images were …
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Evaluating Cancer Rates, Cancer Types, and Variant Hotspots Between Different Races and Ethnicities in Individuals with Li-Fraumeni Syndrome
<p>Li Fraumeni Syndrome (LFS) is a cancer predisposition syndrome that increases the risk for numerous cancer types in both children and adults. In the general population, incidence rates for various cancer types differ among races and ethnicities. Although a few germline <em>TP53 …
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Computational Analysis of Antibody Binding Mechanisms to the Omicron RBD of SARS-CoV-2 Spike Protein: Identification of Epitopes and Hotspots for Developing Effective Therapeutic Strategies
<p>The advent of the Omicron strain of SARS-CoV-2 has elicited apprehension regarding its potential influence on the effectiveness of current vaccines and antibody treatments. The present investigation involved the implementation of mutational scanning analyses to examine the impact of Omicron …
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Modeling of vegetation diversity and a national conservation planning: example of Russia
… einschätzen? 2) Wie ist der Ansatz 'globaler Hotspots' für die Eingrenzung nationaler Biodiversitäts-Hotspots zu übernehmen? 3) Wie erfolgt die Auswahl von quantitativen Schutzzielen unter Einbezug der Unterschiede nationaler Hotspots bei Umweltbedingungen und durch den Menschen Bedrohung? 4) …
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Satpura: A Novel Framework for Density Estimation, Hotspot Discovery, Change Analysis, and Change-based Alerts
… raw and relative densities. To identify density hotspots, we designed a novel hotspot discovery technique that generates rectangular hotspots for a given density threshold. We also developed a post-processing technique to remove redundant and highly overlapping hotspots. Since the density …
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The Role of Antibodies to <i>Plasmodium falciparum</i> Merozoite Antigens in the Resistance of Young Infants to Febrile Malaria and Their Place as a Biomarker in the Detection of Malaria Transmission Hotspots
… geo-spatial data on malaria risk to identify hotspots of clinical malaria and their association with hotspots of serological responses to malaria antigens. We found that 1) antibody responses correlated well with asymptomatic parasitaemia detected by polymerase chain reaction, and 2) there was …
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Analysis and Redesign of Protein-Protein Interactions: A Hotspot-Centric View
… upon mutation, while residues in a few critical "hotspots" drastically reduce affinity when mutated. The organization of protein interfaces into hotspots has a number of important implications. For example, small interfaces can have high affinity, and when multiple binding partners are generated …
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Spatial and Temporal Heterogeneity of Malaria Transmission in sub-Saharan Africa
… heterogeneity was generalizable. Hotspots were identified in all datasets, and were more marked at lower transmission intensity. Given the predictability with which hotspots occur as transmission intensity falls, malaria control programmes should have a low threshold for responding …
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Motor Vehicle Collisions in London, Ontario: Estimating the influence of the built environment and children’s potential exposure
… in London, Ontario (2010-2019) and identifies hotspots using a network kernel density estimation method within a GIS. Logistic regression analysis revealed that bike lanes were negatively associated with hotspots, while sidewalks were positively associated. Study #2 estimated children’s risk of …
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A landscape approach used in designing a representative reserve system for the Eastern Cape Province of South Africa
… richness, endemism and conservation status hotspots. Rules were formulated according to a broad conservation strategy. Once the rules had been set a reserve selection algorithm was run. Four scenarios were looked at: the first scenario merely modelled a reserve system based on the rule that …
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The basking shark Cetorhinus maximus: movement, behaviour and connectivity in the Northeast Atlantic
… depth utilisation during autumnal dispersal from hotspots, might shape the basking shark’s realised thermal environment. Sharks concurrently dispersed into coastal mixed and stratified, offshore tropical and subtropical habitats, where ambient water temperatures experienced reflected habitat …
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Neighborhood characteristics and the spatial concentration of crime: Evidence for Bogotá
… in the neighborhood. The existence of crime hotspots in Bogotá has been shown in most of the literature, and using these non-standard crime statistics at this neighborhood level some hotspots arise again, thus validating the use of a spatial approach for these new crime statistics. The final …
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