Global ETD Search
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Showing 1 to 20 of 20 for “"HilA"”.
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International tax planning and anti-tax avoidance provisions - Hila Zetler.
'The avoidance of tax may be lawful, but it is not yet a virtue' – Lord Denning¹. The famous English judge, Lord Denning, explained that the avoidance of tax may be legal, but it is not necessarily ethical. By said words, Justice Denning implied that, when a taxpayer avoids paying taxes through …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… circuit. The transcriptional regulator HilA activates the expression of the genes encoding the SPI1 T3SS structural and primary effector proteins. The hilA mRNA 5' untranslated region (UTR) is ~350 nucleotides in length and binds the RNA chaperone Hfq, suggesting it is a likely target …
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Integration of small RNAs in the control of Salmonella pathogenicity island 1(SPI1)
… rearrangement and engulfment of the bacteria. HilA activates transcription of the SPI1 structural components and effector proteins. Three AraC-like regulators, HilD, HilC, and RtsA, form a feed-forward regulatory loop that activates transcription of hilA. Many environmental signals and …
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Regulation of the Salmonella Pathogenicity Island 1 Type Three Secretion System
… binding upstream of the master regulatory gene hilA to induce its expression. HilA activates the SPI1 T3SS structural genes. Here I present evidence that hilA expression, and hence the SPI1 T3SS, is controlled by a feedforward regulatory loop. I demonstrate that HilC, HilD, and RtsA are each …
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Control of Salmonella Virulence by Microbiota-Derived and Dietary Fatty Acids
… in Salmonella. Proteomic analysis reveal that HilA, a key virulence transcription regulator, is short-chain fatty acylated. I employ Amber Suppression Technology and CRISPR-Cas9 genome editing to faithfully mimic butyrylation on endogenous HilA. Biochemical and functional characterization show …
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
… expression of the invasion genes by inducing hilA expression. RtSA also induces expression of hilD, hilC, invF, and slrP. RtsA induction of these genes is independent of other SPI1 regulators. RtsA directly induces hilA expression by binding to the promoter. We propose that RtsA, HilC and HilD …
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Regulation of virulence in Salmonella enterica
… in the distal ileum of the host small intestine. HilA, a master regulator of the system, determines the level of SPI1 T3SS in the cell. Three AraC-like regulators, HilD, HilC, and RtsA, directly activate hilA expression, as well as each other and themselves, forming a complex feed-forward …
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Mechanisms of signal integration: Regulation of the SPI1 T3SS
… feed forward loop to activate expression of hilA, encoding the main transcriptional regulator of T3SS structural genes. This system is tightly regulated, with many of the activating signals acting at the level of hilD translation or HilD protein activity. Once inside the phagosome of …
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The Role of Periplasmic Disulfide Bond Status in the Regulation of the Salmonella SPI1 Type Three Secretion System
… cells. The master SPI1 regulatory gene hilA is controlled directly by three AraC-like regulators: HilD, HilC and RtsA. A periplasmic disulfide bond oxidoreductase DsbA is required for SPI1 T3SS function. RtsA directly activates dsbA and deletion of dsbA leads to loss of SPI1-dependent …
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Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
… pre- and post-challenge. High dose of LA (HiLA) induced an anti-inflammatory dendritic cell (DC) profile, characterized primarily by upregulation of TLR2 expression and production of cytokine IL-10. Conversely, low dose of LA (LoLA) upregulated TLR3 and TLR9 and increased secretion of …
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Automaticity and Control in the Effect of Arousal on Persuasion
The study failed to detect the mediating role of accessibility and attribution. This failure is likely to be due to issues related to the measurement sequence. However, the study did show differences in the moderating role of awareness under the different processing strategy conditions. The results …
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Venous materials towards interactive fluidic mechanism
This thesis proposes the vision of Venous Materials which intends to explore the idea that fluid can be considered and manipulated as a tangible digital-physical element for interaction design. Venous Materials suggests a new approach to design interactive materials with means of designing fluidic …
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Geometric manipulation of light : from nonlinear optics to invisibility cloaks
In this work, we study two different manipulations of electromagnetic waves governed by macroscopic Maxwell's equations. One is frequency conversion of such waves using small intrinsic material nonlinearities. We study conversion of an input signal at frequency w1 to frequency Wk due to second or …
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Hilaruuduille simuloitujen toimenpide-ehdotusten johtaminen kuviolle päättelysääntöjen avulla
… alueelle. Puustotunnukset ennustetaan hilaruudukolle, jossa käytettävä hilaruudun koko on 16 x 16 metriä. Aarnissa toimenpidesimulointi perustuu hila-ruuduilta metsikkökuviolle yleistettyjen puustotunnusten keskiarvoihin. Menetelmä ei huomio kuvion sisäistä vaih-telua ja aiheuttaa muun …
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Prevalence, virulence factors and antimicrobial resistance of salmonella species from beef in retail outlets from KwaZulu-Natal province, South Africa
… to screen for the presence of invA, agfA, lpfA, hilA, sivH, sefA, sopE and spvC virulence genes. Salmonellacontamination was observed in 1.25% (5/400) of the beef samples. Four serovars:Enteritidis, Hadar, Heidelberg and Stanley were identified. Almost all Salmonellaisolates were susceptible to …
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Characterization of a Strain of Salmonella Typhimurium Capable of Causing Persistent Infections in Swine
… expression of type III secretion proteins (hilA, invF, sigE) with 1519 expressing these proteins while 1518 did not. Invasion profiles of the two phenotypes reflect the difference in expression of these genes. 1519 cells invaded Henle 407 cells approximately 4 times better than 1518 cells. …
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Influence of Physiological State, Prolonged Dry Storage, and Passage through Simulated Digestion on the Survival and Gene Expression of Salmonella enterica sv. Tennessee
… with stress response (rpoS, otsB), virulence (hilA, hilD, invA, sipC) and a housekeeping gene 16S rRNA using quantitative real-time PCR. The physiological state and length of storage effected the survival and gene expression of Salmonella within the desiccated milk powder environment and after …
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Estudo de virulência de Salmonella spp. isolados de linfonodos mesentéricos suinos: uma abordagem utilizando o sequenciamento de genoma completo
… As analises demonstraram que 38 genes (invA, hilA, orgA, prgK, sipA, sipB, sipC, sipD, slrP, sopA, sopD, sopE2, spaO, sptP, sifA, sseB, sseC, sseL, ssrA, ttrC, spiC, mgtC, sopB, pagN, sodC1, phoP, phoQ, tolC, sdiA, entF, fhuA, leuO, oxyR, slyA, fimA, flgL, flgK, fliC) apresentaram 100% de …
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Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
… fatty acid modification on the virulence factor HilA. In addition, we demonstrated that alkynyl-functionalized short chain fatty acids, like natural fatty acids, can inhibit the secretion of Salmonella virulence factors in vitro. Overall, our results suggest that alkynyl-functionalized fatty …
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El Derecho internacional y el sistema jurídico mexicano: problemas actuales
… y el sistema jurídico mexicano, que hila nuestra empresa cognitiva: el ordenamiento jurídico internacional y los ordenamientos jurídicos nacionales mantienen una ínsita, simbiótica e inextricable conexión. En ésta interrelación el Derecho internacional determina al Derecho nacional en …