Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"High-throughput experimentation"”.
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Mixing in high throughput experimentation reactors
The application of High Throughput Experimentation (HTE) stirred vessels in the catalyst and pharmaceutical industries enable the parallel screening of potential formulations. Such tasks only require a fraction of the raw material and experimental time that are needed in conventional lab scale …
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Integrated microbioreactor arrays for high-throughput experimentation
… capabilities of a stirred tank bioreactor in a high-throughput format. The devices comprise a novel peristaltic oxygenating mixer and microfluidic injectors, which are fabricated using a process that allows combining multiple scale (100/,m-lcm) and multiple depth (100/im-2mm) structures in a …
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Pd-Catalyzed Cross-Coupling, High Throughput Experimentation, and Machine Learning
… (ML) methods have the potential to leverage high throughput experimentation (HTE) data to solve problems in organic chemistry. One such problem is identification of potentially successful reactions for library generation. This work focuses on Pd–catalyzed C–N cross coupling, where the number …
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High throughput experimentation: a validation study for use in catalyst development
High throughput and combinatorial experimentation is becoming more and more used in catalysis research. The benefits of parallel experiments are not only limited to shorten the time - to - market, but also give opportunities to study the process in more depth by performing more experiments. The …
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The Use of High-Throughput Experimentation to Accelerate the Development of Methods for Complex Amine Synthesis
… methods for reaction discovery. The field of high-throughput experimentation (HTE) is vital to achieving these goals. HTE platforms exploit improvements in reaction dosing technology, parallelised reactors and analytical techniques to explore large numbers of reactions simultaneously in a …
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Engineering TEV Protease Specificity: An Exploration of Machine Learning and High-Throughput Experimentation for Protein Design
… to engineer TEV (tobacco etch virus) protease, a highly sequence-specific protease, to cleave alternative substrates. We incorporate novel high-throughput assays and powerful machine learning (ML) methods for highly effective protein engineering. The first portion of this thesis focuses on …
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Smart Re-Manufacturing of Recycled Plastics and Polymers using Sensor-based and High-throughput Experimentation Formats
… properties, and lack of rapid, efficient, and high-throughput experimental-based material screening and design are foundational challenges that limit industrial progress. Toward addressing these challenges, the United States started the Materials Genome Initiative aims to accelerate the pace …
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Novel reaction discovery with rapid high-throughput experimentation via infrared spectroscopy and enzymatic electrochemical oxidation of alcohols
… the idea of sustainability and productivity. High-throughput screening (HTS) and high-throughput experimentation (HTE) has been widely used in the field of biochemistry to rapidly identify pharmacological targets. However, this method has been underused in organic chemistry due to the …
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Sensor-Enabled Accelerated Engineering of Soft Materials
… tools, especially characterization tools for high-throughput experimentation. This dissertation aims to enrich the toolbox by trying new sensor tools for high-throughput characterization of hydrogels. Piezoelectric-excited millimeter-sized cantilever (PEMC) sensors were used in this …
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High-Throughput Profilometric Screening of Corrosion Inhibitors and Molecular Structure Effects on Magnesium Alloy Protection
… inhibitors for Mg and its alloys by combining high-throughput experimentation with profilometric analysis. Using aromatic carboxylates and 2,6-pyridinedicarboxylate (2,6-PDC) as representative examples, the study explores how functional groups influence the corrosion inhibition mechanisms of Mg …
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Protein Design at Library Scale
… progress in both com- putational modeling and high-throughput experimentation. Modern tools can explore vast sequence-structure spaces and evaluate biomolecular interactions, while experimental assays can now screen billions of variants in parallel. Yet, a key limitation remains: our current …
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Integrative approaches to decipher influenza evolution, antibody responses, and AI-driven specificity prediction
… such as SARS-CoV-2 and influenza Viruses, highlights the urgent need to understand immune responses and viral evolution to guide therapeutic and vaccine development. This dissertation integrates high-throughput experimental techniques and artificial intelligence (AI) to address key …
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Ligand Design For The Separation Of Rare Earth Elements
… currently recycled. This situation is due to the high cost of implementing solvent extraction methods to purify these elements from mixtures, compared to the costs associated with primary mining and purification operations. This dissertation describes work on the development of novel ligands that …
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High-Throughput Methods For Reaction Development Using The Mosquito® Liquid Handling Robot
High-throughput technologies have dramatically advanced processes such as drug screening and protein crystallisation. Application of related high-throughput experimentation practices have the potential to revolutionise chemical synthesis. This thesis describes the standardisation and implementation …
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Exploring Nickel Catalysis in Carbonyl and Alcohol Addition Reactions
… secondary alcohol products in moderate to high yields. Key to the success of this transformation was the implementation of underexplored and readily synthesized 1,5-diaza-3,7-diphosphacyclooctane (P2N2) ligands. Chapter 3 extends the methodology established in chapter 2 and aims to get a …
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Benchmarking the Performance of Bayesian Optimization across Multiple Experimental Materials Science Domains
… (BO), have been leveraged for guiding autonomous high-throughput experimentation (HTE) systems. There have been individual studies successfully applying BO in experimental materials optimization, yet very few evaluated the performance of BO as a general optimization algorithm across a broad range …
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EXPLORATION AND MECHANISTIC STUDY OF WEAKLY COORDINATING ANIONS UNDER THERMAL AND PHOTOCHEMICAL CONDITIONS FOR SELECTIVE TRANSFORMATIONS OF C-C MULTIPLE BONDS
… loadings, and additives was conducted using High Throughput Experimentation, HPLC, and LCMS facilities at the GSK site.
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Study of Adsorbate Interactions of Alumina Surfaces Using Nuclear Magnetic Resonance Methods
… a combination of analytical techniques including high throughput experimentation (HTE), advanced NMR techniques, multivariate linear regression (MLR), X-ray diffraction (XRD), nitrogen porosimetry and thermogravimetric analysis (TGA) to address the fundamental research questions; what is the role …
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Machine Learning-aided High-throughput Synthesis and Development of Optoelectronic Materials
… motivated by the advent of readily accessible high-performance computing techniques; and equally by the need to decrease the time in which lab-scale products reach the market. The development of metal-halide perovskites (MHPs) in particular can benefit from accelerated techniques: MHPs have …
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