Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Herc2"”.
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The OCA2-HERC2 Locus: Polymorphisms and Eye Color Determination, Chromatin Organization in the Interphase Nucleus, and Forensic Biotechnology Applications [I geni HERC2 e OCA2: polimorfismi e colorazione degli occhi, organizzazione nel nucleo interfasico e applicazioni biotecnologiche in ambito forense]
… colore degli occhi, influenzato dal locus OCA2-HERC2 e dallo SNP rs12913832. Sebbene efficace per colori chiari e scuri, il metodo mostra limiti nel predire tonalità intermedie, evidenziando la complessità della regolazione genetica. Questo studio ha analizzato la frequenza allelica di …
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Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome
… 3 we examined the interaction between Dube3a and HERC2. HERC2 is also an E3 ubiquitin ligase located in the 15q11.2-q13.1 critical region and is duplicated in all Dup15q individuals. HERC2 physically interacts with and stimulates the ubiquitin ligase activity of UBE3A in vitro. We found that …
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Nprl2/Tusc4 Functions As A Tumor Suppressor By Regulating Brca1’S Stability Via The E3 Ubiquitination Pathway
… protein physically interacts with the E3 ligase HERC2 and prevents ubiquitin pathway-mediated BRCA1 degradation. Knockdown of NPRL2/TUSC4 expression enhanced BRCA1 polyubiquitination, leading to BRCA1 protein degradation and a marked reduction in HR repair efficiency. Conversely, ectopic …
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The Characterization of a Novel Complex Implicated in the Initiation of Apoptosis
… of the complex. The identified subunits are Herc2, Neurl4, SSSCA1 and XIAP. None of the identified subunits, aside from XIAP, have been previously implicated in apoptosis. Using cell culture assays, we have shown that the novel complex acts to degrade XIAP, thus shifting the propensity of …
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Quality control of protein complex assembly
… by the E3 ubiquitin ligases HERC1 and HERC2, respectively. This led to the hypothesis that the KCMF1-UBR4 complex might build ubiquitin chains on pre-ubiquitinated orphans, thereby improving their recognition by the proteasome. *In vitro* reconstitution of orphan ubiquitination by the …