Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 768 for “"Hepatic"”.
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… the Western world1 and results in centrilobular hepatic necrosis. In non-severe cases the liver regenerates to normal microarchitecture and function. However, in severe APAP-induced ALF, transplantation remains the only curative treatment. Hepatic stellate cells (HSCs) play a central role during …
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Hepatic capacitance reponses to changes in flow and hepatic venous pressure in dogs
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The effects of left hepatic vein ligation on hepatic circulation, function and microanatomy
… portography, and histologic assessment of hepatic tissue. The left hepatic vein was ligated in the chronic and acute dogs. The dogs had a ligature placed loosely around the left hepatic vein. Acute and control dogs were evaluated 24 hours postoperatively with the hematologic and biochemical …
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THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
Hepatic lipid metabolism plays a major role in non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. The primary goal of this work was to delineate the role of the hepatic cholesterol-esterifying enzyme acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in cholesterol balance and triglyceride …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
… diet (GAN diet) for 28 weeks and hepatic pathology and metabolism were assessed alongside measures of cardiac, renal and whole-body health and metabolism. Hepatic *Epas1* deletion did not protect against NAFLD, or GAN diet induced hyperglycaemia and hyperlipidaemia, but did …
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Multiscale Modelling of Hepatic Viral Infection
The multiscale modelling of hepatic viral infection was introduced in this work and various approaches were carried out to contribute effectively to the control and eradication of viral hepatitis in sub-saharan Africa. A nested multiscale model was developed by applying the Replication-Transmission …
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Automated Prediction of Hepatic Arterial Stenosis
… have yet to be tested on the less ideal data hepatic arteries generate. Software has been created to extract liver artery Doppler ultrasound information in an automated fashion to predict stenosis. A turnkey approach is utilized to refine the region prior to extraction. Current methods of …
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Liver regeneration by hepatic progenitor cells
… with stem cell like qualities known as hepatic progenitor cells (HPCs). HPCs are particularly active during massive or chronic liver injury and therefore are an attractive target for much needed novel therapies to enhance regeneration in patients for whom the only current effective …
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Hepatic phospholipid remodeling in metabolic disorders
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Isoflurane : interaction with hepatic microsomal enzymes
… interacts with cytochrome P-450 in rat and human hepatic microsomes and the Δ6- and Δ5-desaturases in rat hepatic microsomes. The interaction of isoflurane with cytochrome P-450 results in its metabolism to fluoride ion and organofluorine metabolites. The cytochrome P-450 isozymes catalysing the …
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Genomic analysis of hepatic insulin resistance
… siRNA screening to investigate the effects of hepatic gene transcription during periods of high and low glucose production. This strategy provides a new approach to studying the molecular mechanisms of disease pathogenesis. Our investigations focused on discovering new genes that influence …
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Hepatic Lipid metabolism in Neonatal Pigs
… the amount of MCFA in the formula relieved hepatic steatosis however, only removing the MCFA source entirely from the diet lowered the steatosis below 20% of liver weight. Isolated mitochondria from pigs fed high MCFA formula were unable to oxidize pyruvate and malate as effectively as pigs …
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Effect of obesity on hepatic drug metabolism
Obesity has increased markedly over the last few decades and is now a major public health crisis in the U.S. affecting over 1/3 of the US population. Optimization of dosing in obese individuals is a challenge due to the lack of knowledge regarding changes in the pharmacokinetics (PK) of therapeutic …
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Acetaminophen-induced hepatic necrosis: possible biochemical mechanisms
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Probable mechanism of isoniazid-related hepatic injury
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Sex-Linked Hepatic Esterases in the Rat
Made available in DSpace on 2015-05-12T21:38:24Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 6713462.PDF: 3667061 bytes, checksum: 6ce5b6ac9d07dc3a6f6b0d0f7ceaa409 (MD5) Previous issue date: 1967
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Hepatic acetogenesis and ketogenesis in neonatal swine
… in suckling piglets and evidence of minimal hepatic ketone body production from fatty acids in vitro suggested that, unlike previously-studied neonates, enhanced ketogenesis does not characterize the metabolism of the newborn pig. This apparent idiosyncracy of piglet metabolism prompted a …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
<p>p53 MAINTAINS HEPATIC CELL IDENTITY DURING LIVER REGENERATION</p> <p>Zeynep Hande Coban Akdemir, B.S.,M.A.</p> <p>Advisory Professor: Michelle Craig Barton, Ph.D.</p> <p>p53 is a tumor suppressor that has been well studied in tumor-derived, cultured cells. However, its functions in normal …
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The Role of Akt2 in Hepatic Lipid Metabolism
… of triglycerides in the liver, called hepatic steatosis, though the underlying pathogenesis of this accumulation remains unclear. There is certainly an inappropriate increase in de novo lipogenesis in the livers of individuals with hepatic steatosis, but the insulin signaling pathway …
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Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
… Moreover, litters born from maternal hepatic Ascl1 null mutated dam experienced abnormal postnatal growth after weaning. RNA-seq analysis revealed Ascl1-regulated genes in the maternal liver associated with Ascl1-dependent phenotypes. Of particular interest, we found that, in maternal …
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