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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"Heck"”.
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Oxidative Heck Reactions with Terminal Olefins
… terminal olefin for the vinylic C—H arylation (Heck reaction). This manifold is unique because previous intermolecular Heck reaction conditions require an excess of resonance activated olefin coupling partner. Further exploration of directing groups to determine the underlying directing factors …
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Intramolecular Heck couplings of unactivated alkyl electrophiles : synthetic and mechanistic studies
… for the palladium-catalyzed intramolecular Heck coupling of unactivated alkyl bromides and chlorides is described. The optimal catalyst system was composed of Pd2(MeO-dba)3 as the metal source and N-heterocyclic carbene SIMes as the ligand, and the influence of both parameters is discussed. …
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Behaviour of partially prestressed concrete structures under fatigue loading / by Moo-Heck Foo
One microfiche in pocket
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Development and application of a borylative heck reaction and towards the total synthesis of nimbolide
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Chirality Transfer in Acyclic Allylic Systems and New Pd-Catalyzed Heck Reaction/C-H Activation Cascades
… compounds. In a second part, it was found that Heck reaction leading to neopentylic palladium species underwent, in the absence of nucleophile, a C-H activation reaction, leading to spiro cyclopropyl compounds.
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Development of a Ni-Catalyzed Enantioselective Intramolecular Mizoroki- Heck Reaction for the Synthesis of Phenanthridinone Derivatives
… coupled to the desymmetrizing Mizoroki-Heck reaction is a novel synthetic tool to form potentially bioactive phenanthridinone analogs from inexpensive and easily available starting materials. This work describes a rare example of the direct replacement of palladium for nickel in our …
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Palladium-Imidazolium Carbene Catalyzed Heck Coupling Reactions and Synthesis of a Novel Class of Fluoroanthracenylmethyl PTC Catalysts
<p>Palladium catalyzed Heck coupling with aryl and alkenyl halides has become a powerful means of carbon-carbon bond formation. This standard synthetic method has been developed to a high level of utility using various catalysts, conditions and substrates. Yet significant drawbacks remain, …
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The nickel-catalyzed Mizoroki-Heck reaction : high regioselectivity in Olefin migratory insertion and photoredox-enabled indoline formation
… ...] Achieving high selectivity in the Heck reaction of electronically unbiased alkenes has been a longstanding challenge. Using a nickel-catalyzed cationic Heck reaction, we were able to achieve excellent selectivity for branched products (>/=19:1 in all cases) over a wide range of aryl …
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Exploration of the use of Palladium and Nickel to Catalyze Enolate Cross-coupling and the Enantioselective Mizoroki-Heck Reaction.
… asymmetric intramolecular Mizoroki-Heck reaction to produce potentially bioactive phenanthridinone analogs. We achieve this through the Birch-Heck sequence, a 4-step sequence that includes Birch reduction/alkylation of benzoic acid, acid chloride formation/amide formation, …
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Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
… in situ under mild conditions, via a proposed Heck-type mechanism. The precatalysts are able to facilitate carbonyl-ene, hydroalkenylation, and amination reactions. [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable …
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Exploration of Synthetic Pathways to Quaternary Carbon Stereocenters and Fused Ring Systems via Birch Reductions
… reactions such as the Rauhut-Currier or Mizoroki-Heck, complex drug-like structures can be rapidly formed. We have developed and reported the first example of a Lewis acid mediated Rauhut-Currier reaction as well as the first examples of an enantioselective desymmetrizing aryl vinyl Mizoroki-Heck …
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Hybride amphiphiler hyperverzweigter Polyglycerine mit Metallnanopartikeln und ihre katalytischen Eigenschaften
… In DMAc lösliche Palladiumkolloide waren in der Heck-Reaktion aktiv. Durch eine Ultrafiltration der Kolloide vor der Heck-Reaktion zeigte sich, dass die Kolloide geringe Mengen katalytisch hochaktiver Palladiumspezies enthielten, die vom Kolloid abgetrennt werden konnten und nicht mit …
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Neue Ein-Topf-Sequenzen auf der Basis cyclisierender Isomerisierungen von In-Allylalkoholen
… y,d-Enalen umlagerten. Daneben wurden in Heck-Carbopalladierungsreaktionen ebenfalls In-Allylalkohole eingesetzt, die in einer Folge aus Carbopalladierung, Heck-Reaktion und anschließender Tautomerie ebenfalls y,d-Enale bildeten. Diese so gebildeten y,d-Enale wurden als Diversitätsmodule …
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JULIA-KOCIENSKI APPROACH TO 4-SUBSTITUTED 1- ALKENYL-1H-1,2,3-TRIAZOLES
… gave 1-ethenyl-1H-1,2,3-triazoles. Heck reactions of these products with phenyl or p-methoxyphenyl iodide led to further functionalization of the terminal carbon, with E/Z-olefin ratios ≥ 92%. Heck reaction with p-cyanophenyl iodide gave low conversion, and that with 2-thienyl iodide …
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Palladium-Catalyzed Alkenylsilanol Cross -Coupling Reactions: Method Development and Mechanistic Analysis
… for either palladium-olefin complexation or a Heck-type carbometalation as the turnover-limiting step for these cross-coupling reactions.
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Chemoenzymatic Synthesis of ent-Neopinone
… Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition.
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Development of site-specific RNA labeling strategies to probe alternative RNA splicing
… for the synthesis of C-ribonucleosides, with a Heck reaction as the key step. Specifically, its application in the synthesis of the Z ribonucleoside developed by the Benner group is investigated. The chapter starts with re-introducing the Z/P pair developed by the Benner group and highlighting …
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Novel synthesis of 3,4-fused indoles
… palladium-catalyzed reactions, an intramolecular Heck reaction followed by a reductive N-heteroannulation. Using this route, a number of 3,4-fused indoles were prepared in acceptable yields.
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Supported catalysts, from polymers to gold nanoparticles supports
… were studied. These catalytic reactions are the Heck-Mizoroki, Suzuki-Miyaura and Sonogashira coupling reactions. These transformations became fundamental for the synthesis of drugs and materials. The first and second chapters provide background information by describing and evaluating the main …
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